Blood sugar decreasing polypeptide-k compound capsule and preparation method thereof

A bitter gourd polypeptide, hypoglycemic technology, applied in the directions of capsule delivery, pharmaceutical formulations, peptide/protein components, etc., can solve the problem that the stability and significance of product efficacy cannot be guaranteed, the quality controllability of components and their content, and the preparation time period cannot be guaranteed. It can ensure stability and significance, eliminate diabetic complications, and achieve high absorption and utilization.

Active Publication Date: 2017-12-01
李玉保 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although it has been recognized that bitter melon is a plant raw material with hypoglycemic effect, and it is used in the treatment of diabetes, there are some problems at the same time: First, most of the above-mentioned literature and related Chinese medicine herbal preparations for the treatment of diabetes use various Such formula raw materials are directly pulverized and sieved and then filled and taken, or directly decocted with water or pulverized and then decocted with water. There is no quality controllability and content of key ingredients, and the stability and significance of product efficacy cannot be guaranteed; There are hypoglycemic products that use bitter gourd extracts. Most of the bitter gourd extracts are mainly saponins, which are actually "bitter melon saponins", or the bitter gourd polypeptide protein is obtained by various enzymatic reactions or alkaline extraction and acid precipitation, but its content is not high. High, and the preparation time period is long or the operating temperature of some steps is high, and the natural active bitter melon polypeptide is the key component to effectively regulate blood sugar metabolism

Method used

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  • Blood sugar decreasing polypeptide-k compound capsule and preparation method thereof
  • Blood sugar decreasing polypeptide-k compound capsule and preparation method thereof
  • Blood sugar decreasing polypeptide-k compound capsule and preparation method thereof

Examples

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Effect test

preparation example Construction

[0026] Further, the preparation method of this bitter gourd polypeptide extract comprises:

[0027] a. The bitter gourd raw material is extracted with purified water, and centrifuged to remove slag to obtain a centrate.

[0028] Optionally, choose fresh bitter gourd or dried bitter gourd and bitter gourd seeds as bitter gourd raw materials. The cleaning method is: firstly wash the raw bitter gourd raw materials with tap water, and then wash them with electrolytic high-concentration ozone water. The ozone concentration in the cleaning water can reach 10-20 mg / L , The water flow rate is 150-450L / h, which is used to further remove pesticide residues, microbial residues, etc.

[0029] Further, the method for extracting bitter gourd raw materials with purified water includes: pouring the crushed bitter gourd raw materials into an ultrasonic assisted extraction tank, adding 5 to 10 times the mass of purified water at 38 to 52°C, and adjusting the system by using buffer salts pH = 6...

Embodiment 1

[0052] This embodiment provides a hypoglycemic bitter gourd polypeptide compound capsule, the bitter gourd polypeptide compound capsule includes:

[0053] Bitter gourd polypeptide extract 4Kg, ginsenoside extract 3Kg, pueraria flavone extract 2Kg, astragalus polysaccharide extract 2Kg, trace element chromium 0.7‰.

[0054] Among them, the content of bitter gourd polypeptide in the bitter gourd polypeptide extract is 28%, wherein the content of the bitter gourd polypeptide with a molecular weight of 5.5-7kDa accounts for 22%; the content of ginsenoside in the ginsenoside extract is 25%; The content of flavonoids is 72%, the content of puerarin in the total flavonoids is 48%; the content of astragalus polysaccharide in the extract of astragalus polysaccharide is 21%.

[0055]The preparation method of the bitter gourd polypeptide capsule comprises: combining bitter gourd polypeptide extract, ginsenoside extract, kudzu root extract, astragalus polysaccharide extract and trace elem...

Embodiment 2

[0057] This embodiment provides a bitter gourd polypeptide capsule with hypoglycemic effect, the bitter gourd polypeptide capsule includes:

[0058] Bitter gourd polypeptide extract 3Kg, ginsenoside extract 4Kg, kudzu root extract 1Kg, astragalus polysaccharide extract 3Kg, trace element chromium 0.6‰.

[0059] Among them, the content of bitter gourd polypeptide in the bitter gourd polypeptide extract is 31%, and the content of molecular weight is 5.5~7kDa accounts for 18%; The content of ginsenoside in the ginsenoside extract is 15%; The content of puerarin in the total flavonoids is 45%; the content of astragalus polysaccharide in the extract of astragalus polysaccharide is 15%.

[0060] The preparation method of the bitter gourd polypeptide capsule is consistent with that of Example 1.

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Abstract

The invention provides a blood sugar decreasing polypeptide-k compound capsule and a preparation method thereof and belongs to the field of functional food health or medicine. The compound capsule comprises, by weight, 3-5 parts of a polypeptide-k extract, 2-4 parts of a ginseng saponin extract, 1-3 parts of a kudzu flavonoid extract, 1-3 parts of an astragalus polysaccharide extract and 0.6-0.8%. of trace element chromium. The content of polypeptide-k protein in the polypeptide-k extract is not less than 20%, the content of polypeptide-k 5.5-7kDa in molecular weight accounts for 18-25%, and the polypeptide fragmentation is close to the molecular weight in size. The preparation method includes: mixing the raw materials of the above recipe weight with auxiliaries prior to performing drying and sieving; pelleting by adopting a wet process after superfine grinding before performing drying, sieving and size stabilizing to have the capsule filled according to specifications. The polypeptide-k compound capsule is a pure plant preparation, components with homology of medicine and food are reasonable, the function of blood sugar reduction is remarkable, and the compound capsule can be used for preventing and treating diabetes.

Description

technical field [0001] The invention relates to the field of functional food health care or medicine, in particular to a hypoglycemic bitter gourd polypeptide compound capsule and a preparation method thereof. Background technique [0002] With the continuous improvement of people's living standards and the rapid development of social economy, the number of diabetic patients in my country has shown a rapid growth trend, accounting for about one-third of the total number of diabetic patients in the world. At present, the incidence of diabetes in my country is as high as 9.6%, and the number of diabetic patients has exceeded 110 million, and the number of patients is still increasing year by year. The harm of diabetes is huge, and the complications of diabetes accompanied by diabetes also pose a huge threat to the health and life of patients. Diabetes is called diabetes in ancient times, and it refers to a syndrome characterized by polydipsia, polyuria, polyphagia, weight los...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/01A61K36/42A61K9/48A61P3/10A23L33/105A23L33/18A23L33/125A23L33/16A23P10/30A61K31/715A61K33/24A61K36/488
CPCA23L33/105A23L33/125A23L33/16A23L33/18A23P10/30A23V2002/00A61K9/1652A61K31/715A61K33/24A61K36/258A61K36/42A61K36/488A61K38/011A61K2236/331A61K2236/51A61K2236/53A61K2300/00A23V2200/328A23V2250/21A23V2250/55A23V2250/1586
Inventor 何静仁李玉保
Owner 李玉保
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