Compound Yinhuang composition injection for fever relieving, pain easing and inflammation preventing of animals

An antipyretic and analgesic composition technology, which is applied in the field of compound Yinhuang composition injections, can solve injection safety problems, adverse reactions, local muscle atrophy and other problems, achieve safe and reasonable preparation prescriptions, improve drug efficacy, and reduce allergies Effect

Inactive Publication Date: 2018-02-02
成都导飞科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above dosage forms are inconvenient for veterinary use. Currently, the commonly used and convenient veterinary preparation dosage form is injection, which has high bioavailability and good effect.
However, because Analgin intramuscular injection is likely to cause a sudden drop in blood pressure, and the injection site is prone to redness, swelling, and pain, which can lead to local muscle atrophy and joint disorders, so the use of Analgin injection for humans has been gradually discontinued; for the convenience of veterinary use, consider In order to meet drug compliance and animal safety, it is necessary to solve the problem of serious adverse reactions caused by the injection of the pharmaceutical composition injection containing Sulpyrine
[0021] Patent CN102379920A discloses a veterinary antiviral antipyretic pharmaceutical composition, the prescription contains 1-6 parts of honeysuckle and 1-5 parts of analgin, and the dosage forms include injections and oral preparations, but the patent prescription does not contain Scutellaria baicalensis extract, The effect is not as good as the combination of the three, and the serious adverse reactions caused by the injection containing Analgin are not considered
[0022] Based on the above analysis, the traditional Chinese medicine ingredients honeysuckle extract (calculated as chlorogenic acid) and Scutellaria baicalensis extract (calculated as baicalin) are used in combination with Western medicine Analgin. The combination of Chinese and Western medicines has a synergistic effect and can quickly relieve Heat analgesic and anti-inflammatory, and the effect is long-lasting, which is better than the therapeutic effect of chemical medicine single prescription and pure Chinese medicine preparation, but the safety problem of pharmaceutical composition injection must be solved

Method used

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  • Compound Yinhuang composition injection for fever relieving, pain easing and inflammation preventing of animals
  • Compound Yinhuang composition injection for fever relieving, pain easing and inflammation preventing of animals
  • Compound Yinhuang composition injection for fever relieving, pain easing and inflammation preventing of animals

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-10

[0061] The prescription (5 mL) of compound Yinhuang injection for antipyretic, analgesic and anti-inflammatory in animals of the present invention is .

[0062] Table 1. Example 1-10 formulations.

[0063]

[0064] Note: q.s. means appropriate amount and sufficient amount.

[0065] The preparation method includes the following steps.

[0066] Dissolve antioxidants, metal ion chelating agents and bacteriostatic (pain-relieving) agents in carbon dioxide or nitrogen-saturated water for injection, then add the prescribed amount of Analgin, stir to dissolve to form solution A; take the prescribed amount of yellow Cenium extract (calculated as baicalin) was dissolved in solution A to make solution B; the prescription amount of honeysuckle extract (calculated as chlorogenic acid) was dissolved in carbon dioxide or nitrogen-saturated water for injection to make solution C; Mix solution B and solution C, make up the prescribed amount of water for injection, adjust the pH to 5.5-...

Embodiment 11-20

[0068] The prescription (emulsion type injection, 100mL) of compound Yinhuang injection for antipyretic, analgesic and anti-inflammation in animals of the present invention is as follows.

[0069] Table 2. Example 11-20 formulations.

[0070]

[0071] Note: q.s. means appropriate amount, sufficient amount.

[0072] The preparation method includes the following steps.

[0073] (1) Preparation of the oil phase: add the prescribed amount of Scutellaria baicalensis extract (calculated as baicalin) and antioxidants to soybean oil, stir until completely dissolved and become transparent, and use as the oil phase for later use.

[0074] (2) Preparation of water phase: add metal ion chelating agent, antibacterial (pain-relieving) agent, freezing point regulator, emulsifying (solubilizing) agent and polyethylene glycol 400 into water for injection, and then add the prescribed amount of honeysuckle while stirring extract (calculated as chlorogenic acid) and analgin, and make it di...

Embodiment 21-30

[0079] The prescription of compound Yinhuang injection (suspension injection or sterile powder for injection, 20 mL) for antipyretic, analgesic and anti-inflammatory in animals of the present invention is as follows.

[0080] Table 3. Example 21-30 formulations.

[0081]

[0082] Note: ＊ Indicates that this excipient is only added to powder for injection.

[0083] The preparation method includes the following steps.

[0084] Add antioxidants, metal ion chelating agents, antibacterial (pain-relieving) agents, buffer salt ion pairs, suspending agents, and wetting agents to 20 mL of water for injection, dissolve, filter, and sterilize by flowing steam at 100 °C for 30 min. After cooling, as a solvent, add honeysuckle extract (calculated as chlorogenic acid), Scutellaria baicalensis extract (calculated as baicalin) and analgin in a sterile room to prepare a suspension injection.

[0085] Or antioxidants, metal ion chelating agents, antibacterial (pain-relieving) agents, bu...

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Abstract

The invention discloses a compound Yinhuang composition injection for fever relieving, pain easing and inflammation preventing of animals, and an application thereof, belongs to the field of veterinary drugs, and concretely relates to a medicinal composition containing honeysuckle flower extract (by chlorogenic acid), Radix Scutellariae extract (by baicalin) and metamizole sodium, and active components of the medicinal composition comprise, by weight, 1-10 parts of the honeysuckle flower extract (by chlorogenic acid), 1-100 parts of the Radix Scutellariae extract (by baicalin) and 10-1000 parts of the metamizole sodium. The dosage form of the medicinal composition can be any one of a solution type injection, a suspension type injection, an emulsion type injection and a sterile powder for injection. The compound Yinhuang composition injection has obvious synergistic effect and a remarkable treatment effect when used for the for fever relieving, pain easing and inflammation preventing ofanimals, and has the advantages of effective reduction of untoward effects of medicines, stable quality, high safety, simple preparation method, and suitableness for industrial production.

Description

technical field [0001] The invention relates to a compound Yinhuang composition injection for antipyretic, analgesic and anti-inflammation for animals and application thereof. It belongs to the field of veterinary medicine. Background technique [0002] With the rapid development of my country's intensive breeding industry and the continuous improvement of feeding and management levels, the incidence of various common diseases of livestock and poultry has decreased, while febrile diseases characterized by fever (including various acute infections in Western veterinary medicine) Diseases and infectious diseases) the incidence rate is on the rise, such as swine flu, blue ear disease, porcine streptococcal disease, avian influenza, mad cow disease, foot-and-mouth disease, schistosomiasis and other diseases seriously damage the healthy development of animal husbandry, resulting in the growth of livestock and poultry It is suppressed, and the production performance is reduced, whi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/216A61K31/7048A61K31/4152A61K36/355A61K36/539A61K9/08A61P29/00
CPCA61K31/216A61K9/0019A61K9/08A61K31/4152A61K31/7048A61K36/355A61K36/539A61K2300/00
Inventor 张凌
Owner 成都导飞科技有限公司
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