Medicine slow-release coating material with core-shell structure
A technology of coating material and shell-core structure, applied in the field of medicine, can solve the problems of limited clinical effect, poor adhesion, expensive re-implantation, etc., and achieves good sustained release speed, promotion of osseointegration, and good biocompatibility. Compatibility with water-soluble drugs
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Embodiment 1
[0025] A drug sustained-release coating material with a shell-core structure, characterized in that: the preparation method of the coating material follows the steps below:
[0026] Step 1, dissolving PCL in a mixed solution of dimethylformamide and chloroform, and stirring evenly to obtain a 10% (w / v) PCL solution as a shell solution;
[0027] Step 2, dissolving PVA in distilled water to prepare a 10% (w / v) PVA solution;
[0028] Step 3, dissolving doxycycline hydrochloride in distilled water to prepare a 50 mg / mL aqueous solution of doxycycline hydrochloride;
[0029] Step 4, adding the doxycycline hydrochloride aqueous solution into the PVA solution, stirring evenly to obtain a mixed solution as the nuclear layer solution;
[0030] In step 5, the shell layer solution and the core layer are respectively loaded into a conventional coaxial electrospinning device, and coaxial electrospinning is carried out to obtain a drug sustained-release coating material.
[0031] The volu...
Embodiment 2
[0040] A drug sustained-release coating material with a shell-core structure, characterized in that: the preparation method of the coating material follows the steps below:
[0041] Step 1, dissolving PCL in a mixed solution of dimethylformamide and chloroform, and stirring evenly to obtain a 10% (w / v) PCL solution as a shell solution;
[0042] Step 2, dissolving PVA in distilled water to prepare a 10% (w / v) PVA solution;
[0043] Step 3, dissolving doxycycline hydrochloride in distilled water to prepare a 50 mg / mL aqueous solution of doxycycline hydrochloride;
[0044] Step 4, adding the doxycycline hydrochloride aqueous solution into the PVA solution, stirring evenly to obtain a mixed solution as the nuclear layer solution;
[0045] In step 5, the shell layer solution and the core layer are respectively loaded into a conventional coaxial electrospinning device, and coaxial electrospinning is carried out to obtain a drug sustained-release coating material.
[0046] The volu...
Embodiment 3
[0055] A drug sustained-release coating material with a shell-core structure, characterized in that: the preparation method of the coating material follows the steps below:
[0056] Step 1, dissolving PCL in a mixed solution of dimethylformamide and chloroform, and stirring evenly to obtain a 10% (w / v) PCL solution as a shell solution;
[0057] Step 2, dissolving PVA in distilled water to prepare a 10% (w / v) PVA solution;
[0058] Step 3, dissolving doxycycline hydrochloride in distilled water to prepare a 50 mg / mL aqueous solution of doxycycline hydrochloride;
[0059] Step 4, adding the doxycycline hydrochloride aqueous solution into the PVA solution, stirring evenly to obtain a mixed solution as the nuclear layer solution;
[0060] In step 5, the shell layer solution and the core layer are respectively loaded into a conventional coaxial electrospinning device, and coaxial electrospinning is carried out to obtain a drug sustained-release coating material.
[0061] The volu...
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