Medicine slow-release coating material with core-shell structure

A technology of coating material and shell-core structure, applied in the field of medicine, can solve the problems of limited clinical effect, poor adhesion, expensive re-implantation, etc., and achieves good sustained release speed, promotion of osseointegration, and good biocompatibility. Compatibility with water-soluble drugs

Inactive Publication Date: 2018-02-06
WUXI ZHONGKE GUANGYUAN BIOMATERIALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Late lesion treatment and reimplantation are expensive
Since 1987, hydroxyapatite-coated titanium implants have been put into clinical application, but the defects of hydroxyapatite, such as brittleness, poor adhesion, and explosive release of drugs, limit its clinical effect.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] A drug sustained-release coating material with a shell-core structure, characterized in that: the preparation method of the coating material follows the steps below:

[0026] Step 1, dissolving PCL in a mixed solution of dimethylformamide and chloroform, and stirring evenly to obtain a 10% (w / v) PCL solution as a shell solution;

[0027] Step 2, dissolving PVA in distilled water to prepare a 10% (w / v) PVA solution;

[0028] Step 3, dissolving doxycycline hydrochloride in distilled water to prepare a 50 mg / mL aqueous solution of doxycycline hydrochloride;

[0029] Step 4, adding the doxycycline hydrochloride aqueous solution into the PVA solution, stirring evenly to obtain a mixed solution as the nuclear layer solution;

[0030] In step 5, the shell layer solution and the core layer are respectively loaded into a conventional coaxial electrospinning device, and coaxial electrospinning is carried out to obtain a drug sustained-release coating material.

[0031] The volu...

Embodiment 2

[0040] A drug sustained-release coating material with a shell-core structure, characterized in that: the preparation method of the coating material follows the steps below:

[0041] Step 1, dissolving PCL in a mixed solution of dimethylformamide and chloroform, and stirring evenly to obtain a 10% (w / v) PCL solution as a shell solution;

[0042] Step 2, dissolving PVA in distilled water to prepare a 10% (w / v) PVA solution;

[0043] Step 3, dissolving doxycycline hydrochloride in distilled water to prepare a 50 mg / mL aqueous solution of doxycycline hydrochloride;

[0044] Step 4, adding the doxycycline hydrochloride aqueous solution into the PVA solution, stirring evenly to obtain a mixed solution as the nuclear layer solution;

[0045] In step 5, the shell layer solution and the core layer are respectively loaded into a conventional coaxial electrospinning device, and coaxial electrospinning is carried out to obtain a drug sustained-release coating material.

[0046] The volu...

Embodiment 3

[0055] A drug sustained-release coating material with a shell-core structure, characterized in that: the preparation method of the coating material follows the steps below:

[0056] Step 1, dissolving PCL in a mixed solution of dimethylformamide and chloroform, and stirring evenly to obtain a 10% (w / v) PCL solution as a shell solution;

[0057] Step 2, dissolving PVA in distilled water to prepare a 10% (w / v) PVA solution;

[0058] Step 3, dissolving doxycycline hydrochloride in distilled water to prepare a 50 mg / mL aqueous solution of doxycycline hydrochloride;

[0059] Step 4, adding the doxycycline hydrochloride aqueous solution into the PVA solution, stirring evenly to obtain a mixed solution as the nuclear layer solution;

[0060] In step 5, the shell layer solution and the core layer are respectively loaded into a conventional coaxial electrospinning device, and coaxial electrospinning is carried out to obtain a drug sustained-release coating material.

[0061] The volu...

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Abstract

The invention belongs to the technical field of medicines, and particularly relates to a medicine slow-release coating material with a core-shell structure. The medicine slow-release coating materialis prepared by the following steps of dissolving PCL (polycaprolactone) into a mixed solution of dimethylformamide and chloroform, so as to prepare a shell layer solution; dissolving PVA (polyvinyl alcohol) into water, and mixing with a Doxycycline water solution, so as to obtain a core layer solution; finally, adding the shell layer solution and the core layer solution into a conventional coaxialelectrospinning device, and performing electrostatic spinning, so as to obtain the medicine slow-release coating material. The medicine slow-release coating material has the advantages that a biodegradable macromolecular implant material with a nanometer structure is prepared by a high-pressure electrostatic spinning technology, and can be used for well simulating the microstructure of bone extracellular matrix; the compatibility is improved, and the bone integration is promoted.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a drug slow-release coating material with a shell-core structure. Background technique [0002] In orthopedic implant surgery, defects in implant osseointegration can lead to implant instability, fretting, osteolysis, and loosening, which in turn lead to early implant failure. The speed and quality of osseointegration are closely related to the biological, physical and chemical properties of the implant surface. According to research, the probability of infection around the implant after total joint replacement surgery is greater than 2%, and the probability of implant infection in later revision surgery will greatly increase. About 15% of hip joint and 15% of knee joint replacement surgery will be due to implant Infection occurs in the body. Later lesion treatment and reimplantation are expensive. Since 1987, hydroxyapatite-coated titanium implants have been put ...

Claims

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Application Information

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IPC IPC(8): A61L27/34A61L27/50A61L27/54A61L27/58D01D5/00D01D5/34
CPCA61L27/34A61L27/50A61L27/54A61L27/58A61L2300/406A61L2300/602A61L2420/02A61L2420/08A61L2430/02D01D5/003D01D5/34C08L29/04C08L67/04
Inventor 孟庆怡许杉杉赵亮亮黄健翔
Owner WUXI ZHONGKE GUANGYUAN BIOMATERIALS
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