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Preparation method and applications of GMDA-Au NPs composite material

A composite material, proportional mixing technology, applied in the direction of analyzing materials, material resistance, material electrochemical variables, etc., can solve the problem of less detection, and achieve the effect of low detection limit, good reproducibility and high sensitivity

Active Publication Date: 2018-02-23
NANJING NORMAL UNIV CHANGZHOU INST OF INNOVATION & DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0008] At present, the main detection methods for sulfonamides at home and abroad include high performance liquid chromatography (HPLC), capillary electrophoresis (CE), solid phase extraction (SPE), chromatography-mass spectrometry and enzyme-linked immunosorbent assay (ELISA). ), etc., the detection of SD-Na is less, and the permanent stop titration method is the main method

Method used

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  • Preparation method and applications of GMDA-Au NPs composite material
  • Preparation method and applications of GMDA-Au NPs composite material
  • Preparation method and applications of GMDA-Au NPs composite material

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preparation example Construction

[0037] The preparation steps of GMDA resin: add 2g gelatin, 1.05g Na in reaction vessel 3 PO 4 , 4.2g Na 2 HPO 4 , 32g NaCl and 200mL H 2 o 2 , and then sequentially added 12.5g divinylbenzene (DVB), 12.5g glycidyl methacrylate (GM), 1g benzoyl peroxide (BPO), 1g azobisisobutyronitrile (AIBN) and 25g C 6 h 5 CH 3 , the mixture was stirred at 368K for 12h at a speed of 400rpm, and the resin white ball was obtained after the system was cooled and filtered; then CH 3 CH 2 OH and H 2 O Clean the resin white balls and dry them in vacuum for 12 hours; take out the resin white balls, place them in a container, add 250 mL of 5M dimethylamine (DA) aqueous solution, react at 400 rpm for 12 hours, cool, filter and clean the resin, and dry them in vacuum for 12 hours; Resin added excess CH 2 ClCH 2 Cl and FeCl 3 After cross-linking at 353K for 24h, CH 3 OH, HCl and H 2 O was washed and dried in vacuum for 12 hours to obtain GMDA resin.

[0038] Preparation steps of Au NPs s...

Embodiment 1

[0040] A preparation method of GMDA-Au NPs composite material: prepare 10 mg / mL GMDA resin solution, take the supernatant after ultrasonication for 24 hours, mix it with Au NPs solution at a volume ratio of 3:5, and then obtain it after ultrasonication for 1 hour .

Embodiment 2

[0042] A preparation method of GMDA-Au NPs composite material: prepare 30mg / ml GMDA resin solution, take the supernatant after ultrasonication for 24 hours, mix it with Au NPs solution at a volume ratio of 5:2, and then obtain it after ultrasonication for 4 hours .

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Abstract

The present invention belongs to the technical field of nanometer composite materials, and relates to an amino modified interpenetrating resin (GMDA resin), particularly to preparation of a GMDA-Au NPs composite material, and applications of the GMDA-Au NPs composite material in quantitative analysis of sodium sulfadiazine. The preparation method comprises: preparing a 10-30 mg / ml GMDA resin solution, carrying out ultrasonic treatment for 24 h, taking the supernatant, mixing the supernatant and a Au NPs solution according to a volume ratio of 3:5-5:2, and carrying out ultrasonic treatment for1-4 h to obtain the product. According to the present invention, the composite material GMDA-Au NPs is synthesized by using the macroporous amino resin (GMDA resin) through the ultrasonic method, andis characterized and analyzed; the material is immobilized on the surface of the glassy carbon electrode by using the drip coating method, the modified electrode is electrochemically characterized respectively through the cyclic voltammetry curve and the alternating current impedance spectroscopy, and on the basis of the optimized conditions, the SD-Na in the water environment is quantitatively detected by using the differential pulse voltammetry method and the differential pulse stripping voltammetry method; and the method has advantages of simple operation, good reproducibility and low detection limit, and provides the new method and idea for the detection of sulfanilamide-based antibiotics in real samples.

Description

technical field [0001] The invention belongs to the technical field of nanocomposite materials, and relates to an amino-modified interpenetrating resin (GMDA resin), in particular to a preparation method and application of a GMDA-Au NPs composite material. Background technique [0002] Synthetic sulfa drugs are a class of broad-spectrum antibiotics, widely used in the treatment of various diseases such as respiratory and digestive tract infections; in addition, as an additive to promote animal growth, they can also be used to treat bacterial infections in animals. However, researchers have found that sulfonamides have strong drug resistance, and long-term accumulation in the body can easily lead to disorders of the urinary system and hematopoietic system, and have a serious impact on human or animal health. Sulfadiazine sodium (SD-Na), as a short-acting sulfonamide compound, can be used for the treatment of immunodeficiency syndrome, epidemic cerebrospinal meningitis, and to...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/30G01N27/48G01N27/04
CPCG01N27/041G01N27/301G01N27/308G01N27/48
Inventor 杨小弟景丽君林军费琪琪
Owner NANJING NORMAL UNIV CHANGZHOU INST OF INNOVATION & DEV
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