Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Developing drug-carrying titanium alloy stent

A titanium alloy, drug-carrying technology, applied in the field of medical devices, can solve problems such as poor systemic drug effect, and achieve the effects of improving clinical practicability, stable properties, and avoiding adverse reactions

Inactive Publication Date: 2018-02-27
CHENGDU SHENGERJIA SCI & TECH
View PDF11 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Cardiovascular pharmacology studies have found that a variety of drugs can produce significant inhibitory effects on vascular intima and smooth muscle cells in vitro, but the effect of systemic administration is not good, and the reason may be related to the low concentration required for internal circulation

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Developing drug-carrying titanium alloy stent
  • Developing drug-carrying titanium alloy stent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] This embodiment provides a visualized vascular stent, which includes a stent body 1, a visualization structure 3 and an intima, and the stent body 1 is sleeved on the intima. The developing structure 3 is disposed on the support body 1 .

[0042]The stent body 1 is in a hollow tubular structure, and the tube wall is in a hollow mesh structure. The bracket body 1 is divided into a symmetrical upper tube wall 12 and a lower tube wall 13 by the plane where the central axis of the hollow tubular structure is. The stent body 1 in this embodiment can be made of any implantable material in the prior art, such as medical stainless steel or medical polymer material. The diameter of the stent body 1 gradually decreases from the middle to both ends, and the diameter of the two ends is 75%-80% of the diameter of the middle part. In the non-slip vascular stent provided by the present invention, the length of the stent body 1 is 0.5-20 cm, and the diameter of the stent body 1 is 1....

Embodiment 2

[0047] This embodiment provides a glycidyl methacrylate-polylactic acid film, the film is hollow, and the cavity can accommodate guest molecules to increase the contact area with the guest molecules. This glycidyl methacrylate-polylactic acid film is prepared by the following method:

[0048] Weigh polylactic acid and polyethylene glycol respectively according to the mass ratio of 2.3:0.7, disperse them in dimethyl sulfoxide, and heat to 50°C to obtain a polylactic acid mixture; according to the mass of glycidyl methacrylate and polylactic acid Weigh glycidyl methacrylate with a ratio of 0.6:1, and add it to the polylactic acid mixture, stir evenly, and then pass nitrogen gas for 30 minutes to form a nitrogen protection, then add a catalytic amount of azobisisobutyronitrile, and heat up to 60 ℃ and maintained under the protection of nitrogen for free radical polymerization for 20 hours to obtain the casting solution. The casting solution was defoamed and filtered and poured in...

Embodiment 3

[0050] This embodiment provides a kind of method that the hollow glycidyl methacrylate-polylactic acid film diamine grafted in embodiment 2 is mixed with losartan to simultaneously carry out physical and chemical drug loading on losartan, the method includes Follow the steps below:

[0051] Soak the glycidyl methacrylate-polylactic acid film in deionized water, and add tetramethylethylenediamine to the deionized water according to the mass ratio of tetramethylethylenediamine to glycidyl methacrylate-polylactic acid film at 0.1:3. ethylenediamine, and reacted at room temperature for 24 hours to obtain a diamine-grafted glycidyl methacrylate-polylactic acid film. After washing off unreacted tetramethyldiamine with deionized water, soak it in fresh deionized water. The mass ratio of therapeutic formulation to glycidyl methacrylate-polylactic acid film is 0.1:2 Add therapeutic formulation to deionized water and add catalytic amount of 1-ethyl-(3-dimethylaminopropyl) carbon Diimin...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Thicknessaaaaaaaaaa
Thicknessaaaaaaaaaa
Lengthaaaaaaaaaa
Login to View More

Abstract

The invention discloses a developing drug-carrying titanium alloy stent, and relates to the field of medical devices. The developing drug-carrying titanium alloy stent comprises a stent body, a developing structure and an inner membrane; the stent body is made of titanium alloy, has a hollow tubular structure, and a tube wall forms a net-like structure; and the developing structure is arranged ina hollow part of the net-like structure and connected with the stent body, and a developing agent is fixed on the surface of the developing structure; the inner membrane is sleeved with the stent body; the inner membrane includes a base layer and a drug carrying layer; the base layer is correspondingly connected with the stent body and the drug carrying layer; and the drug carrying layer is fixedwith a treated preparation. On the one hand, the inner membrane prevents formation of early thrombus, and on the other hand, the treated preparation controls occurrence of restenosis, and together guarantee patency of blood vessels after intervention of the stent. The stent is also provided with the developing structure, solves a problem of invisibility during stent implantation and post-operationfollow-up. The stent body adopts titanium alloy support to avoid adverse reactions caused by nickel-containing stainless steel and improves clinical practicality.

Description

technical field [0001] The invention relates to the field of medical devices, in particular to a developable drug-loaded titanium alloy stent. Background technique [0002] Percutaneous puncture angioplasty, referred to as PTA, is under the guidance of medical imaging equipment, using a puncture needle, a guide wire and a guide sheath to insert a balloon catheter with a tightened stent into a human blood vessel and deliver it to the blood vessel At the stenosis, with the expansion of the balloon, the stent is also stretched. After the balloon is retracted and retracted, the plastically deformed metal stent remains in place and is embedded in the blood vessel, playing the role of dilating the blood vessel. At present, this method is widely used in the treatment of cardiovascular and peripheral obstructive diseases. According to statistics, more than 80% of cardiovascular and peripheral obstructive diseases are treated with this method. [0003] The stenosis of blood vessels...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61F2/91A61M31/00A61L31/02A61L31/06A61L31/16A61L31/14A61L31/18
CPCA61F2/91A61L31/022A61L31/06A61L31/14A61L31/16A61L31/18A61L2300/416A61L2300/436A61M31/002A61M2210/12A61M2210/005C08L67/04C08L81/06
Inventor 卢晔
Owner CHENGDU SHENGERJIA SCI & TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com