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A three-dimensional printing wound dressing material based on silk microsphere bioink and its preparation method

A bio-ink and three-dimensional printing technology, applied in the field of wound covering materials, can solve the problems of low strength of fiber membranes, and achieve the effects of ensuring air permeability, wound covering, and uniformity

Active Publication Date: 2020-09-25
YANCHENG INST OF IND TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, most wound dressing materials are made of functional materials through electrospinning technology to form fiber membranes. The strength of the prepared fiber membranes is low, and most of them contain chemical cross-linking agents. Biocompatibility and long-term antibacterial properties need to be improved.

Method used

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  • A three-dimensional printing wound dressing material based on silk microsphere bioink and its preparation method
  • A three-dimensional printing wound dressing material based on silk microsphere bioink and its preparation method
  • A three-dimensional printing wound dressing material based on silk microsphere bioink and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] (1) Centrifuge the aqueous solution of aspirin-coated silk protein microspheres with a particle size of 1-5 μm, remove the supernatant, add the silk protein aqueous solution, stir ultrasonically, and mix uniformly to obtain a silk protein solution containing silk protein microspheres. The mass fraction of silk protein microspheres coated with aspirin is 3%, and the mass fraction of silk protein is 5%.

[0034] (2) Add 1 wt% of ultraviolet light initiator Irgacure I-2959 and 3 wt% of polyvinyl alcohol ester to the silk protein solution containing silk protein microspheres, and mix them uniformly to obtain silk microsphere bio-ink.

[0035] (3) Transfer the silk microsphere bio-ink to the needle cylinder of the three-dimensional printer, use cotton gauze as the printing base cloth, establish a cyclically cyclical cross net-like support model in the MIMICS software, and adjust the needle cylinder pillow and cotton gauze The distance is 0.5mm, the silk microsphere bio-ink is pri...

Embodiment 2

[0037] (1) Centrifuge the aspirin-coated silk protein microsphere aqueous solution with a particle size of 1-5 μm, remove the supernatant, add the silk protein aqueous solution, stir ultrasonically, and mix uniformly to obtain a silk protein solution containing silk protein microspheres. The mass fraction of silk protein microspheres coated with aspirin is 5%, and the mass fraction of silk protein is 5%.

[0038] (2) Add 1 wt% of ultraviolet light initiator Irgacure I-2959 and 3 wt% of polyvinyl alcohol ester to the silk protein solution containing silk protein microspheres, and mix them uniformly to obtain silk microsphere bio-ink.

[0039] (3) Transfer the silk microsphere bio-ink to the needle cylinder of the three-dimensional printer, use cotton gauze as the base, and establish a cyclically cyclic cross-net-like scaffold model in the MIMICS software, and adjust the distance between the needle cylinder pillow and the cotton gauze as 0.5mm, the silk microsphere bio-ink is printed...

Embodiment 3

[0041] (1) Centrifuge the aqueous solution of aspirin-coated silk protein microspheres with a particle size of 1-5 μm, remove the supernatant, add the silk protein aqueous solution, stir ultrasonically, and mix uniformly to obtain a silk protein solution containing silk protein microspheres. The mass fraction of silk protein microspheres coated with aspirin is 4%, and the mass fraction of silk protein is 5%.

[0042] (2) Add 1 wt% of ultraviolet light initiator Irgacure I-2959 and 3 wt% of polyvinyl alcohol ester to the silk protein solution containing silk protein microspheres, and mix them uniformly to obtain silk microsphere bio-ink.

[0043] (3) Transfer the silk microsphere bio-ink to the needle cylinder of the three-dimensional printer, use cotton gauze as the base, and establish a cyclically cyclic cross-net-like scaffold model in the MIMICS software, and adjust the distance between the needle cylinder pillow and the cotton gauze as 0.5mm, the silk microsphere bio-ink is pri...

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Abstract

The invention provides a 3D-printing wound dressing material based on silk microsphere bio-ink and a preparation method thereof. The preparation method includes the following steps: transferring silkmicrosphere bio-ink, which includes silk protein microspheres coating aspirin, silk protein water solution, ultraviolet initiator and polyvinyl alcohol ester, into a syringe of a 3D-printing machine;with a cotton gauze as a base printing cloth, printing the surface of the cotton gauze with the silk microsphere bio-ink according to a periodically circulated cross-network structure model; and rapidly curing and shaping the 3D-printing wound dressing material under ultraviolet irradiation. The product is based on 3D-printing technology, wherein the formed cross-network structure contains regularly arranged silk microspheres, and the silk microsphere bio-ink coating layer cures on the surface of the cotton gauze and does not completely penetrate through the cotton gauze. The 3D-printing wounddressing material has good mechanical performance and biocompatibility and excellent slow-release performance, can protect a wound for a long time and can accelerate healing of the wounding.

Description

Technical field [0001] The invention belongs to the technical field of wound coating materials, and in particular relates to a three-dimensional printing wound coating material based on silk microsphere bio-ink and a preparation method thereof. Background technique [0002] Three-dimensional printing technology, also known as three-dimensional rapid prototyping technology or additive weaving technology, is an emerging manufacturing technology, which is based on the principle of layered manufacturing, layer by layer, under computer control, according to the computer-aided design model of the object or Computer tomography and other data, through the accurate three-dimensional accumulation of materials, the technology to quickly weave three-dimensional products of arbitrary complex shapes. [0003] At present, most of the inks used for 3D printing are biocompatible and biodegradable polymer materials. Commonly used ink materials are made of thermoplastic, silicone, collagen, gelatin o...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/32A61L15/44A61L15/26A61L15/46
CPCA61L15/26A61L15/32A61L15/44A61L15/46A61L2300/21A61L2300/404A61L2300/412A61L2300/622C08L29/04C08L89/00
Inventor 王曙东马倩王可
Owner YANCHENG INST OF IND TECH