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Polymer gel particles, preparation method thereof, composite gel particles containing polymer gel particles and application of composite gel particles

A technology of polymer gel and composite gel, which is applied in the field of biomedical polymer materials, can solve the problems of low drug loading of nanoparticles, decreased effective concentration, and easy burst release.

Active Publication Date: 2018-03-30
INST OF PROCESS ENG CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

For example, compared with micron-sized particles, nanoparticles have a low drug loading capacity (usually less than 5%), and are prone to burst release when loaded, which greatly reduces the effective concentration of the drug reaching the target site, thus greatly weakening the The delivery effect of nanocarriers limits its commercial application (Nanoparticles in drug delivery: Past, present and future. Advanced Drug Delivery Reviews 65(2013) 21–23)

Method used

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  • Polymer gel particles, preparation method thereof, composite gel particles containing polymer gel particles and application of composite gel particles
  • Polymer gel particles, preparation method thereof, composite gel particles containing polymer gel particles and application of composite gel particles
  • Polymer gel particles, preparation method thereof, composite gel particles containing polymer gel particles and application of composite gel particles

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Experimental program
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Effect test

Embodiment 1-3

[0088] Embodiment 1-3 provides chitosan derivative gel particle, adopts high-pressure homogeneous method to prepare, and concrete steps are as follows:

[0089] The chitosan derivative was dissolved in 8 mL of water phase, and stirred magnetically at room temperature and 500 rpm for 3 h until completely dissolved. Under the condition of ice bath, 2 mL of ion crosslinking agent solution was added dropwise to the above chitosan derivative solution, magnetically stirred at 500 rpm for 5 min, and then solidified in an oil bath for a period of time to form a hydrogel. Add water to the above hydrogel to 25mL, and preliminarily crush and refine it. Then add the preliminarily broken hydrogel mixture into the liquid storage cup of the high-pressure homogenizer, adjust the pressure and the number of cycles, and shear the chitosan derivative gel particles by the high-pressure homogenizer.

[0090] The kind and concentration of chitosan derivatives, the kind of aqueous phase, the kind an...

Embodiment 4-11

[0097] Embodiment 4-11 provides composite chitosan derivative gel particles, which are prepared by high-pressure homogeneous method, and the specific steps are as follows:

[0098] The chitosan derivative was dissolved in 8 mL of water phase, and stirred magnetically at room temperature and 500 rpm for 3 h until completely dissolved. Under the condition of ice bath, 2 mL of ion crosslinking agent solution was added dropwise to the above chitosan derivative solution, magnetically stirred at 500 rpm for 5 min, and then solidified in an oil bath for a period of time to form a hydrogel. Add functional substances and water to the above hydrogel to 25mL, and preliminarily crush and refine it. Then add the preliminarily broken hydrogel mixture into the liquid storage cup of the high-pressure homogenizer, adjust the pressure and the number of cycles, and shear the composite chitosan derivative gel particles by the high-pressure homogenizer.

[0099] The kind and concentration of chit...

Embodiment 12-14

[0110] Embodiments 12-14 provide chitosan derivative gel particles, which are prepared by microporous membrane emulsification method, and the specific steps are as follows:

[0111] The chitosan derivative was dissolved in 8 mL of water phase, and stirred magnetically at room temperature and 500 rpm for 3 h until completely dissolved. Under the condition of ice bath, 2 mL of ion crosslinking agent solution was added dropwise to the above chitosan derivative solution, magnetically stirred at 150 rpm for 10 min, and then solidified in an oil bath for a period of time to form a hydrogel. Add the water phase to the above hydrogel to 25mL, and preliminarily crush and refine it. Then add the preliminary broken hydrogel mixture into the liquid storage bottle of the rapid membrane emulsifier, press the microporous polytetrafluoroethylene membrane with nitrogen under a certain pressure, and obtain chitosan derivative gel particles after repeated membrane passage .

[0112] The kind a...

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Abstract

The invention provides polymer gel particles, a preparation method thereof, composite gel particles containing the polymer gel particles and an application of the composite gel particles. The Young modulus of the polymer gel particles is 5-5000Pa, the average particle size is 100nm-100[mu]m, the polydispersity index is less than 0.5, and an organic solvent is not contained. The polymer gel particles are obtained by the following steps: performing cross-linking on a polymer aqueous solution to form a hydrogel with a Young modulus of 5-5000Pa, then performing preliminary crushing and refining onthe hydrogel, and using a fluid shearing method to prepare the polymer gel particles. The composite gel particles include the above polymer gel particles, and a functional substance supported on thepolymer gel particles. According to the method provided by the invention, organic solvents or surfactants are not used in the process of preparing the polymer gel particles, the obtained polymer gel particles are safe and reliable, the particle size is controllable in the range from the nanometer to the micrometer, the particle sizes are uniform, and the prepared composite gel particles can be used in the fields of biomedicines and the like.

Description

technical field [0001] The invention belongs to the technical field of biomedical polymer materials, and in particular relates to a polymer gel particle, a preparation method thereof, a composite gel particle containing the polymer gel particle and its application. Background technique [0002] With the help of small-scale effects, surface / interface effects, and quantum size effects, nano-microparticles are widely used in biomedical fields (such as drug delivery, vaccine adjuvants, tissue engineering, molecular imaging), chemical and environmental fields (such as daily chemicals, bionic materials, etc.) , microcarriers, enzyme catalysis, biological separation, sewage treatment) show broad application prospects. Among the many materials used to prepare nano-micro particles, the most commonly used are polymer materials, including natural polymers (such as polysaccharides, polypeptides) and synthetic polymers (such as high molecular weight alcohols, acrylic acid and their deriv...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J13/00A61K47/36A61K47/42A61K47/32A61K47/34A61K47/10A61K39/39A61K8/65A61K8/73A61K8/88A61K8/86A61K8/81A61Q19/00
CPCA61K8/65A61K8/73A61K8/731A61K8/732A61K8/733A61K8/736A61K8/8129A61K8/8141A61K8/8152A61K8/86A61K8/88A61K39/39A61K47/10A61K47/32A61K47/34A61K47/36A61K47/42A61K2039/55511A61K2039/55516A61K2039/55583A61K2800/10A61Q19/00B01J13/0065
Inventor 马光辉岳华吴颉吴楠苗春宇周炜清
Owner INST OF PROCESS ENG CHINESE ACAD OF SCI
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