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Preparation method of high-strength degradable porous biological ceramic

A bioceramic, high-strength technology, applied in the field of preparation of high-strength degradable porous bioceramics, can solve the problems of reducing the mechanical strength and poor degradation performance of bioceramics, and achieve a controllable three-dimensional connected three-dimensional porous structure, good degradability, and connectivity. Good results

Inactive Publication Date: 2018-04-10
胡果青
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The main technical problem to be solved by the present invention is to provide a high-strength degradable porous bioceramic preparation method for the defects that the pores of the porous bioceramic will reduce the mechanical strength of the bioceramic and the degradation performance is poor

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0028]In parts by weight, take 80 parts of calcium hydrogen phosphate powder and 30 parts of calcium carbonate, mix and stir for 10 minutes, place them in a mortar and grind for 45 minutes, pass through a 200-mesh sieve to obtain sifted mixed calcium powder, and place the sifted mixed calcium powder in a resistor In the furnace, energize and heat up to 930°C at a rate of 100°C / min, hold the temperature for 4 hours, and naturally cool to room temperature to obtain calcium phosphate powder; take the calcium phosphate powder out of the resistance furnace, grind for 30 minutes, and pass through a 200-mesh sieve To obtain the sieved calcium phosphate powder, place the sieved calcium phosphate powder in a resistance furnace, heat up to 1000° C., sinter at high temperature for 3 hours, and naturally cool to room temperature to obtain lightly burned calcium phosphate powder; in parts by weight, 20 1 part of calcium carbonate, 50 parts of ammonium dihydrogen phosphate, 5 parts of light ...

example 2

[0030] In terms of parts by weight, take 85 parts of calcium hydrogen phosphate powder and 35 parts of calcium carbonate, mix and stir for 13 minutes, place them in a mortar and grind for 50 minutes, pass through a 200-mesh sieve to obtain sifted mixed calcium powder, and place the sifted mixed calcium powder in a resistor In the furnace, energize and heat up to 945°C at a rate of 100°C / min, hold the temperature for 4.5 hours, and naturally cool to room temperature to obtain calcium phosphate powder; take the calcium phosphate powder out of the resistance furnace, grind for 33 minutes, and pass through 200 mesh Sieve the sieved calcium phosphate powder, place the sieved calcium phosphate powder in a resistance furnace, power on and heat up to 1025°C, sinter at high temperature for 3.5h, and naturally cool to room temperature to obtain lightly burned calcium powder; in parts by weight, Mix 25 parts of calcium carbonate, 55 parts of ammonium dihydrogen phosphate, 7 parts of light...

example 3

[0032] In terms of parts by weight, take 90 parts of calcium hydrogen phosphate powder and 40 parts of calcium carbonate, mix and stir for 15 minutes, place them in a mortar and grind for 55 minutes, pass through a 200-mesh sieve to obtain sifted mixed calcium powder, and place the sifted mixed calcium powder in a resistor In the furnace, energize and program the temperature to 960°C at a rate of 100°C / min, hold the temperature for 5 hours, and naturally cool to room temperature to obtain calcium phosphate powder; take the calcium phosphate powder out of the resistance furnace, grind for 35 minutes, and pass through a 200-mesh sieve To obtain the sieved calcium phosphate powder, place the sieved calcium phosphate powder in a resistance furnace, heat up to 1050° C., sinter at high temperature for 4 hours, and naturally cool to room temperature to obtain lightly burned calcium phosphate powder; in parts by weight, 30 1 part of calcium carbonate, 60 parts of ammonium dihydrogen ph...

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Abstract

The invention relates to the technical field of biomedical material preparation, in particular to a preparation method of high-strength degradable porous biological ceramic. According to the method, light calcined calcium powder is self-made and mixed with biological glass powder, polystyrene foam microspheres are doped, the mixture is soaked in a paraffin section solution, and high-solid-phase slurry is obtained; hot-pressing molding is carried out to obtain a green body, and the degradable biological ceramic is obtained after the green body is subjected to deparaffinage, pore forming and sintering. Channels communicated with one another are reserved after ignition loss of the foam microspheres and are controlled according to the contact compact degree between the microspheres, and the larger the contact area of biological matter and the biological ceramic is, the more the strength of the biological ceramic is improved. The porous ceramic is of a special structure, and cell adhesion growth, extracellular matrix deposition, entering of nutrition and oxygen and the like are facilitated; the light calcined calcium powder is easy to biodegrade, so that the porous biological ceramic has relatively good degradation performance and has wide application prospects in the aspect of inducing bone regeneration.

Description

technical field [0001] The invention relates to the technical field of preparation of biomedical materials, in particular to a preparation method of high-strength degradable porous bioceramics. Background technique [0002] Bioceramics refers to a class of ceramic materials used for specific biological or physiological functions, that is, ceramic materials that are directly used in the human body or directly related to the human body for biological, medical, and biochemical purposes. As a bioceramic material, it needs to meet the following conditions: biocompatibility, mechanical compatibility, excellent affinity with biological tissues, antithrombotic, sterilizing and good physical and chemical stability. Bioceramics are widely used in orthopedics, dentistry, plastic surgery, cardiovascular surgery, oral surgery and general Surgery etc. [0003] Bone defects caused by fractures, bone diseases and bone cysts have always been one of the difficult problems in the field of or...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C04B35/057C04B38/06C04B35/622C03C12/00A61L27/02A61L27/10A61L27/12A61L27/50A61L27/56A61L27/58
Inventor 龙国华何俊欣张淑娴
Owner 胡果青
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