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A kind of nude flower purple bead coating agent and preparation method thereof

A technology of naked flower violet beads and film coating agent, which can be used in pharmaceutical formulations, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc. effects, etc.

Active Publication Date: 2021-01-26
HAINAN MEDICAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Market survey finds, the naked flower purple pearl preparation has dosage forms such as tablet, capsule, mixture, dispersible tablet, suppository and vaginal tablet in the market at present, and the naked flower purple pearl preparation has certain toxic adverse reactions in the prior art, and First pass effect, low bioavailability
The existing technology lacks external preparations for hemostasis, and the development of external hemostatic preparations of Nadiflora can not only fill the vacancy in the market, but also better exert the hemostatic effect of Nadiflora through the characteristics of the patch

Method used

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  • A kind of nude flower purple bead coating agent and preparation method thereof
  • A kind of nude flower purple bead coating agent and preparation method thereof
  • A kind of nude flower purple bead coating agent and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0085] 1, a kind of preparation method of naked flower purple bead coating agent, it is characterized in that, comprises the following steps:

[0086] (1) Preparation of Auranthus nudiflora extract

[0087] Take 100g of the purple pearl medicinal material, soak it for 2 hours first, then add 12, 10, and 10 times the volume of water respectively, extract 3 times in sequence, each extraction time is 1 hour, combine the extracts, and concentrate to obtain the purple pearl medicinal material extract;

[0088] Take the medicinal extract of Auranthus nudica, dilute it with water, centrifuge at 5000rpm for 10min, take the upper part of the centrifuged aqueous solution, centrifuge the water to dissolve the macroporous resin, first elute with water, then elute with 50% ethanol by volume concentration, and combine 50% ethanol for elution solution, concentrated appropriately; then add 1 / 3 of the ethanol eluent volume of n-butanol to extract 3 times, and extract the n-butanol solution, d...

Embodiment 2

[0095] 1, a kind of preparation method of naked flower purple bead coating agent, it is characterized in that, comprises the following steps:

[0096] (1) Preparation of Auranthus nudiflora extract

[0097] Take 100g of the purple pearl medicinal material, soak it for 2 hours first, then add 12, 10, and 10 times the volume of water respectively, extract 3 times in sequence, each extraction time is 1 hour, combine the extracts, and concentrate to obtain the purple pearl medicinal material extract;

[0098] (2) Preparation of film-forming agent

[0099] (2.1) Take 12 g of polyvinyl alcohol, 40 ml of water, and 60 ml of ethanol 95%, and heat to reflux until the polyvinyl alcohol dissolves to obtain a phase A polyvinyl alcohol solution;

[0100] (2.2) Get 6g of chitosan, add 10ml of water, 1.5ml of acetic acid, stir and mix to obtain phase B chitosan solution;

[0101] (2.3) Get the A-phase polyvinyl alcohol solution and the B-phase chitosan solution, mix well, add 3g of glycer...

Embodiment 3

[0104] 1, a kind of preparation method of naked flower purple bead coating agent, it is characterized in that, comprises the following steps:

[0105] (1) Preparation of Auranthus nudiflora extract

[0106] Take 100g of the purple pearl medicinal material, soak it for 2 hours first, then add 12, 10, and 10 times the volume of water respectively, extract 3 times in sequence, each extraction time is 1 hour, combine the extracts, and concentrate to obtain the purple pearl medicinal material extract;

[0107] Take the medicinal extract of Auranthus nudica, dilute it with water, centrifuge at 5000rpm for 10min, take the upper part of the centrifuged aqueous solution, centrifuge the water to dissolve the macroporous resin, first elute with water, then elute with 50% ethanol by volume concentration, and combine 50% ethanol for elution solution, concentrated appropriately; then add 1 / 3 of the ethanol eluent volume of n-butanol to extract 3 times, and extract the n-butanol solution, d...

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Abstract

The invention discloses a nudibranch purple bead film coating agent and a preparation method thereof. The nude flower purple bead film coating agent is made of nude flower purple bead extract and a film-forming agent, and the film-forming agent includes A-phase polyvinyl alcohol solution, phase B chitosan solution and glycerol. The concentration of the extract of Auranthus nudica is 1.0g / mL~2.0g / mL in terms of crude drug amount. The present invention screens through a large number of experiments to obtain the best preparation method of the nudibranch extract and the preparation method of the film-forming agent. The film-coating agent prepared by the present invention has stable properties, good film-forming properties, high absorbency, and good hemostatic activity, and can be prepared as an external preparation to avoid first-pass elimination, reduce adverse reactions, and is convenient to use. The raw materials are mild and less irritating.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a film-coating agent of nudiflora purple pearls and a preparation method thereof. [0002] technical background [0003] Callicarpanudiflora Hook. et Arn is a plant of the genus Callicarpa Linn. of the Verbenaceae family, also known as Catch the Wind Chai, Festival Red, Hundred Flowers Tea, Fantangye, Yasaifan, etc. It is mainly distributed in Hainan, my country. In Hainan, Guangxi, Guangdong and other places, naked flower purple pearl is a commonly used Li medicinal material in Hainan. Mainly distributed in Baisha, Wuzhishan Qiongzhong and other places. Naked flower purple pearl can be harvested in four seasons as a medicinal material. Take the dry part of naked flower purple pearl on the ground, dry it in the shade, remove impurities and use it for medicine. It has the effects of antibacterial, anti-inflammatory and detoxification, astringent and ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/70A61K36/85A61K47/36A61P7/04
CPCA61K9/7015A61K36/85A61K47/36A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K2236/55
Inventor 张俊清张仲李秀敏李海龙张旭光
Owner HAINAN MEDICAL COLLEGE
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