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Chitosan-containing oral ulcer membrane and preparation method thereof

A technology of oral ulcer and chitosan, which is applied in the field of oral ulcer film containing chitosan and its preparation, can solve the problems of unsatisfactory actual curative effect of oral ulcer, achieve the effect of improving pain relief effect, strong anti-inflammatory activity and improving efficacy

Inactive Publication Date: 2018-05-01
GUANGZHOU RAINHOME PHARM&TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The problem that this invention exists is: its raw material is less, causes the actual curative effect to oral ulcer not ideal

Method used

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  • Chitosan-containing oral ulcer membrane and preparation method thereof
  • Chitosan-containing oral ulcer membrane and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] The mouth ulcer film containing chitosan is made of the following raw materials in parts by weight: 5 parts of sodium alginate, 20 parts of chitosan, 15 parts of honeysuckle, 0.5 part of menthol, 3 parts of vitamin B2, 2 parts of vitamin C, and 0.5 part of borneol , 0.5 parts of steviol glycoside, 1.5 parts of lidocaine, 10 parts of glycerin, 3.5 parts of devil ginger extract, 1 part of okra extract, 150 parts of purified water.

[0036] The preparation method of this oral ulcer film comprises the following steps:

[0037] (1) Air-dry the leaves of the devil ginger and pulverize them with a pulverizer, pass through a 60-mesh sieve to obtain the devil ginger leaf powder, add the devil ginger leaf powder to 35 times the weight of ethyl acetate, soak for 1.5 hours, and place it in an ultrasonic extraction kettle In the process, after heating to 45°C and ultrasonically extracting at 700W ultrasonic power for 18 minutes to obtain the extract, the extract was filtered under r...

Embodiment 2

[0044] Oral ulcer film containing chitosan, made of the following raw materials in parts by weight: 20 parts of sodium alginate, 10 parts of chitosan, 5 parts of honeysuckle, 1 part of menthol, 2 parts of vitamin B2, 0.5 parts of vitamin C, borneol 3 parts, 0.1 part of steviol glycoside, 2 parts of lidocaine, 25 parts of glycerin, 3 parts of devil ginger extract, 0.8 part of okra extract, 140 parts of purified water.

[0045] Its preparation method is the same as Example 1.

Embodiment 3

[0047] Oral ulcer film containing chitosan, made of the following raw materials in parts by weight: 15 parts of sodium alginate, 5 parts of chitosan, 20 parts of honeysuckle, 3 parts of menthol, 0.5 parts of vitamin B2, 3 parts of vitamin C, borneol 1 part, 2 parts of steviol glycoside, 0.1 part of lidocaine, 20 parts of glycerin, 5 parts of devil ginger extract, 0.5 part of okra extract, 100 parts of purified water.

[0048] Its preparation method is the same as Example 1.

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Abstract

The invention provides a chitosan-containing oral ulcer membrane. The chitosan-containing oral ulcer membrane is prepared from the following raw materials in parts by weight: 5 to 20 parts of membrane-forming agent, 5 to 20 parts of chitosan, 5 to 20 parts of honeysuckle flower, 0.5 to 3 percent of menthol, 1 to 6 parts of vitamin, 0.5 to 3 parts of borneol, 0.1 to 2 parts of sweetening agent, 0.1to 2 parts of analgesic, 10 to 25 parts of moisturizing solvent, 3 to 5 parts of Jerusalem artichoke extract, 0.5 to 1 part of okra extract and 100 to 150 parts of water. The invention also providesa preparation method of the chitosan-containing oral ulcer membrane. The chitosan-containing oral ulcer membrane provided by the invention has good antibacterial, anti-inflammation, analgesic and antiallergic effects and has very good curative effect on the oral ulcer.

Description

technical field [0001] The invention relates to an oral ulcer film, in particular to an oral ulcer film containing chitosan and a preparation method thereof. Background technique [0002] Oral ulcer is comparatively common oral mucosa lesion, and its sickness rate is higher. Clinically common oral ulcers include recurrent oral ulcers, oral ulcers caused by viruses, and traumatic oral ulcers. The etiology of most oral ulcers is still unknown so far. In terms of treatment, in addition to systemic medication, antibiotics, synthetic antibacterial drugs, hormones, vitamins, and traditional Chinese medicines with the effects of clearing away heat, nourishing yin, astringing muscles and promoting muscle growth are generally used locally in the form of film preparations, and certain curative effects have been obtained. In view of the fact that the oral ulcer membrane can become a sol after water immersion, adhere to the mucosal surface, release the drug in the membrane for a long t...

Claims

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Application Information

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IPC IPC(8): A61K36/355A61K9/70A61K47/36A61P1/02A61P29/00A61P31/02A61K31/045A61K31/167A61K31/375A61K31/525A61K31/722
CPCA61K9/006A61K9/7007A61K31/045A61K31/167A61K31/375A61K31/525A61K31/722A61K36/185A61K36/28A61K36/355A61K47/36A61K2300/00
Inventor 李炎车七石
Owner GUANGZHOU RAINHOME PHARM&TECH CO LTD
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