Colon-released probiotic tablet

A technology of probiotic tablets and probiotics, applied in the direction of antifungal agents, medical preparations containing active ingredients, coatings, etc., can solve the problems of low colonic survival rate, easy diarrhea, poor adaptability to medication, etc.

Inactive Publication Date: 2018-05-08
乐普制药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But for the elderly and children, the yogurt-type taste is too sour, and it is easy to cause diarrhea
Capsules with colon-targeting effect, because the main component of capsules is gelatin, which is sticky when exposed to water, and the adaptability of taking medicine is not good
There are also probiotic chewable tablets for children on the market. The probiotics in the stomach and duodenum are affected by gastric acid, bile acid and some enzymes, and the survival rate of reaching the colon is low.

Method used

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  • Colon-released probiotic tablet
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  • Colon-released probiotic tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-3

[0017] The preparation technology of embodiment 1-3 probiotic tablet

[0018]

[0019]

[0020] Preparation process: (1) Uniformly mix the probiotic powder and the filler for 10 minutes in a blender.

[0021] (2) Then all the materials are passed through a 40-mesh sieve.

[0022] (3) Dry granulator was used for granulation, the hydraulic pressure was 20 Bar, the rolling wheel speed was 5 rpm, the feeding speed was 10 rpm, and the granulation and crushing screen was 24 mesh.

[0023] (4) After adding the lubricant, use an 8mm punch to press the tablet, and press the tablet according to the weight of the tablet calculated from the content of probiotics.

Embodiment 4-6

[0024] The preparation technology of embodiment 4-6 probiotic tablet

[0025]

[0026] Preparation process: (1) Uniformly mix the probiotic powder and the filler for 10 minutes in a blender.

[0027] (2) Then all the materials are passed through a 40-mesh sieve.

[0028] (3) Dry granulator was used for granulation, the hydraulic pressure was 20 Bar, the rolling wheel speed was 5 rpm, the feeding speed was 10 rpm, and the granulation and crushing screen was 24 mesh.

[0029] (4) After adding the lubricant, use an 8mm punch to press the tablet, and press the tablet according to the weight of the tablet calculated from the content of probiotics.

Embodiment 7-11

[0030] The screening of embodiment 7-11 probiotic tablet coating powder

[0031]

[0032]

[0033] (1) Preparation of coating powder: Add the coating powder materials into 65% ethanol aqueous solution in sequence, and stir for 45 minutes.

[0034] (2) In the coating machine, the tablet is coated according to 5%, and the temperature of the tablet bed is controlled below 35 degrees.

[0035] (3) Bacterial counts are carried out on each sample after coating: the release rate is measured by the blue-turning method, the rotating speed is 100rpm, the temperature is 37 degrees, and each coating weight gain takes 1 tablet and puts it into 400mL of pH1.2 hydrochloric acid medium to make Dissolve for 2 hours, then add pH 1.2 hydrochloric acid medium into NaOH dilute solution, adjust the pH value to 6.8±0.02, then add artificial small intestine fluid to 700mL, observe for 3h, and take 1mL of artificial small intestine fluid. Continue to add artificial colon solution to 1000mL, con...

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PUM

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Abstract

The invention discloses a colon-released probiotic tablet and a preparation method thereof. The probiotic preparation is composed of a probiotic material and a colon-release material. The probiotic material comprises one or more of probiotic powder and pharmaceutically acceptable auxiliary materials, the probiotic powder comprises one or more of bifidobacterium longum, bifidobacterium bifidum, streptococcus thermophilus, lactobacillus acidophilus and lactobacillus delbrueckii subsp. The pharmaceutically acceptable auxiliary materials comprise one or more of a filling agent, a disintegrating agent and a lubricant. The colon-release material comprises one or more of calcium pectin, polyacrylic resin, chitosan, amylose, guar gum, chondroitin sulfate and sodium alginate.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a colon-releasing probiotic tablet. technical background [0002] Probiotics are a type of active microorganisms that are beneficial to the host. They are a general term for active beneficial microorganisms that colonize the human intestinal tract and reproductive system and can produce definite health effects to improve the host's micro-ecological balance and exert beneficial effects. Probiotics are roughly divided into three categories, including Lactobacillus (Lactobacillus acidophilus, Lactobacillus casei, Lactobacillus jannasii, Lactobacillus Lamansii, etc.), Bifidobacteria (such as Bifidobacterium longum, Bifidobacterium breve, etc.) Bacillus, Bifidobacterium ovale, Bifidobacterium thermophile, etc.), Gram-positive cocci (such as Streptococcus faecalis, Lactococcus, Streptococcus intermedia, etc.), in addition, some yeasts can also be classif...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/741A61K9/36A61K9/32A61P1/12A61P1/14A61P31/10A61P15/00A61P3/06A61P1/00A61P19/10A61K35/745A61K35/744A61K35/747
CPCA61K35/741A61K9/2095A61K9/284A61K9/286A61K35/744A61K35/745A61K35/747A61K2300/00
Inventor 宋林奇张金梁俞悦潘裕生王海翔洪华斌
Owner 乐普制药科技有限公司
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