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Preparation method for hemostatic seeping fluid absorption wound repairing material

A technology for wound repair and absorption of exudate, which is applied in the field of medical materials, can solve the problems of unfavorable wound tissue surface healing, inability to quickly absorb wound tissue surface, and dehydration of wound tissue surface, so as to reduce the degree of macroscopic phase separation, prevent cross-infection, Promotes healing effects

Inactive Publication Date: 2018-05-22
周荣
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Technical problem to be solved by the present invention: Aiming at the problem that the air and moisture permeability of the existing repair materials is too high, it is easy to dehydrate the wound tissue surface and cannot quickly absorb the exuded tissue fluid of the wound wound surface, which is not conducive to the rapid healing of the wound tissue surface. A kind of preparation method of wound repairing material of hemostatic absorption liquid

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0022] Take 10g of sodium alginate, add it to 200mL of deionized water, stir at 300r / min for 20min, then add 10g of 5% sodium periodate solution, and add 2.0g of ethylene glycol after 20h of light-shielding reaction, and continue stirring for 10min to obtain Reaction solution, add 20g of sodium chloride and 200g of absolute ethanol to the reaction solution, stir at 400r / min for 20min, let it stand for 1h and then filter to get the filter residue, redisperse the filter residue in 200mL of deionized water, and then precipitate with absolute ethanol, After repeating the operation twice, put it in a vacuum drying oven, and dry it at 30°C for 8 hours to obtain oxidized sodium alginate. Take 5g glycolic acid, 10g acetic anhydride, 0.2g mass fraction of 98% sulfuric acid solution, 1g chitosan, and add 20g mass fraction of 20% acetic acid solution, stirred and reacted at 30°C for 60h, then settled with absolute ethanol until no precipitate was produced, filtered to obtain the precipita...

example 2

[0024] Take 11g of sodium alginate, add it into 220mL of deionized water, stir at 350r / min for 25min, then add 11g of 5% sodium periodate solution, and add 2.2g of ethylene glycol after 22h of light-shielding reaction, and continue stirring for 12min to obtain Reaction solution, add 22g of sodium chloride and 220g of absolute ethanol to the reaction solution, stir at 450r / min for 25min, let it stand for 1h and filter to obtain the filter residue, redisperse the filter residue in 250mL deionized water, and then precipitate with absolute ethanol, After repeating the operation 2 times, place it in a vacuum drying oven and dry at 35°C for 9 hours to obtain oxidized sodium alginate. Take 8g glycolic acid, 15g acetic anhydride, 0.3g mass fraction of 98% sulfuric acid solution, 1g chitosan, add 30g mass fraction of 20% acetic acid solution, stirred and reacted at 35°C for 70h, then settled with absolute ethanol until no precipitate was produced, filtered to obtain the precipitate, was...

example 3

[0026]Take 12g of sodium alginate, add it to 240mL of deionized water, stir at 400r / min for 30min, then add 12g of 5% sodium periodate solution, and add 2.4g of ethylene glycol after 24h of light-shielding reaction, and continue stirring for 15min to obtain For the reaction solution, add 24g of sodium chloride and 240g of absolute ethanol to the reaction solution, stir at 500r / min for 30min, let it stand for 2h and then filter to obtain the filter residue, redisperse the filter residue in 300mL of deionized water, and then precipitate with absolute ethanol, After repeating the operation 3 times, place it in a vacuum drying oven and dry it at 40°C for 10 hours to obtain oxidized sodium alginate. Take 10g glycolic acid, 20g acetic anhydride, 0.4g mass fraction of 98% sulfuric acid solution, 2g chitosan, add 40g mass fraction of 20% acetic acid solution, stirred and reacted at 40°C for 80h, then settled with absolute ethanol until no precipitate was produced, filtered to obtain th...

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Abstract

The invention relates to a preparation method for a hemostatic seeping fluid absorption wound repairing material, and belongs to the technical field of medical materials. Sodium alginate is oxidized by sodium periodate to prepare oxidized sodium alginate with efficient antibacterial performance, glycolic acid is used for grafting chitosan, reaction with a Schiff base and thiol oxidation are performed to prepare an in-situ gelatinized interpenetrating dual-network structure, and a reticular fiber structure is formed at a wound, so that the adhesion of regenerative cells is improved, healing oftissues is promoted by antibacterial and blood coagulation effects of bletillae rhizoma polysaccharide, the chitosan, the sodium alginate and the like, high antibacterial activity, high seeping fluidabsorption capability, good hemostatic effects, good hemostatic and antibacterial effects and high moisture absorption and swelling performance are achieved, invasion of dust and microorganisms can beeffectively prevented, cross infection can be prevented, damaged tissues can be repaired, healing of the wound can be promoted, the wound can be effectively protected, the healing speed of the woundcan be increased, and a dressing is close in fiber bonding, higher in mechanical performance and convenient to change, and has a broad application prospect.

Description

technical field [0001] The invention relates to a preparation method of a hemostatic and seepage-absorbing wound repairing material, which belongs to the technical field of medical materials. Background technique [0002] The skin plays a very important role in maintaining the stability of the internal environment of the organism and preventing the invasion of bacteria and viruses. If the skin is damaged in a large area, it will cause local or even systemic problems such as excessive loss of water and protein, increased metabolism, and imbalance of the immune system. Human life is at risk. The function of repairing or recreating skin is the ultimate goal of wound repair materials. However, before self-skin repair or new construction, wound repair materials with good comprehensive performance can temporarily replace the skin, providing a good environment for the repair of wound tissue surface and the reconstruction of skin tissue. Ideal wound repair materials should have th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/42A61L15/46A61L15/28
CPCA61L15/42A61L15/225A61L15/46A61L2300/404A61L2300/412A61L2300/418A61L2400/04C08L5/04C08L5/08C08L5/00
Inventor 周荣王文新蔡静
Owner 周荣
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