Coenzyme Q10 and octacosanol compounded type nanostructure lipid carrier and preparation method thereof

A technology of nanostructured lipids and octacosanol, which can be used in pharmaceutical formulations, medical preparations containing no active ingredients, medical preparations containing active ingredients, etc., and can solve the problem of low drug loading rate and unpublished particle size of aqueous solution And other issues

Active Publication Date: 2018-05-29
SHENYANG WANJIA INST OF BIOLOGICAL TECH RES +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

③ Chinese patent CN100998438A octacosanol emulsion and its preparation method describes the preparation method of octacosanol emulsion, which involves the method of preparing octacosanol emulsion with the highest content of 1.5% by emulsification method. The content of the patent is not The particle size of its aqueous solution is announced, and the process does not involve key steps such as the preparation of nanostructured lipid carriers such as cooling
The above patents are all about coenzyme Q 10 or octacosanol alone to prepare nanostructured lipid carriers and other related technical content, wherein the published literature shows that coenzyme Q 10 The drug loading rate of nanostructured lipid carriers is usually low, and the drug loading rate is generally below 24%. Octacosanol is not involved in the technical content of nanostructured lipid carriers

Method used

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  • Coenzyme Q10 and octacosanol compounded type nanostructure lipid carrier and preparation method thereof
  • Coenzyme Q10 and octacosanol compounded type nanostructure lipid carrier and preparation method thereof
  • Coenzyme Q10 and octacosanol compounded type nanostructure lipid carrier and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0036] oxidized coenzyme Q 10 2 parts, 1 part of octacosanol, 1 part of caprylyl capric acid glyceride (ODO), 0.001 part of vitamin E, 1 part of decaglyceryl laurate, 1 part of decaglyceryl stearate.

[0037] Weigh 4g oxidized coenzyme Q 10 . Add polyglycerol stearate to 200mL water at 90°C, stir and mix well to form a water phase; slowly add the above oil phase to the water phase, and use a shearer to cut at 16000rpm for 1 minute to form colostrum; then use high pressure Homogenizer, under the pressure of 60MP, through N 2 protection, after 5 cycles, an emulsion is formed, cooled to room temperature, and a nanostructured lipid carrier aqueous solution is obtained. After determination, the average particle size is 112.9nm, the potential is (-27.5±4.99)mV, coenzyme Q 10 The drug loading rate and encapsulation efficiency of the drug were 32.5% and 97.4%, respectively, and the drug loading rate and encapsulation efficiency of octacosanol were 15.9% and 95.3%, respectively.

Embodiment 2

[0039]oxidized coenzyme Q 10 1 part, 2 parts of octacosanol, 1 part of caprylic and capric glyceride (ODO), 0.002 parts of vitamin E, 1.5 parts of Tween-80, 1.5 parts of soybean lecithin.

[0040] Weigh 2g oxidized coenzyme Q 10 , 4g octacosanol, 2g caprylic acid glyceride (ODO), 0.004g vitamin E were heated and melted at 85°C, stirred and mixed to form an oil phase; 3g Tween-80, 3g soybean lecithin were weighed and added Stir and mix in 250mL water at 85°C to form a water phase; slowly add the above oil phase to the water phase, and use a shearer to cut at 16000rpm for 1.5 minutes to form colostrum; then use a high-pressure homogenizer to Under pressure, pass N 2 Protection, after 7 cycles, an emulsion is formed, rapidly cooled to room temperature, and an aqueous solution of a nanostructured lipid carrier is obtained. After determination, the average particle size is 210.6nm, coenzyme Q 10 The drug loading rate and encapsulation efficiency of the drug were 13.6% and 95.5%...

Embodiment 3

[0042] oxidized coenzyme Q 10 1 part, 1 part of C22-C36 higher fatty alkanol mixture containing 70% octacosanol, 0.5 part of caprylic and capric glyceride (ODO), 0.003 part of vitamin E, 0.2 part of soybean lecithin, polyethylene glycol Alcohol-12-hydroxystearate (HS15) 1.8 parts.

[0043] Weigh 2g oxidized coenzyme Q 10 , 2g of C22-C36 higher fatty alkanol mixture containing 70% octacosanol, 1g of caprylic, capric acid glyceride (ODO), 0.006g of vitamin E were heated and melted at 70°C, stirred and mixed to form an oil phase; Weigh 0.4g soybean lecithin, 3.6g polyethylene glycol-12-hydroxystearate (HS15) into 150mL water at 70°C, stir and mix well to form a water phase; slowly add the above oil phase to the water phase, use Shearing machine, after shearing 2 minutes with 16000rpm, forms colostrum; Then use high-pressure homogenizer, under the pressure of 30MP, pass N 2 protection, after 10 cycles, an emulsion is formed, rapidly cooled to room temperature, and a nanostructu...

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Abstract

The invention discloses a coenzyme Q10 and octacosanol compounded type nanostructure lipid carrier and a preparation method thereof, and belongs to the technical field of medicines and health-care products. The coenzyme Q10 and octacosanol compounded type nanostructure lipid carrier is mainly prepared from the following raw materials in parts by weight: 1 to 5 parts of coenzyme Q10, 1 to 2 parts of octacosanol, 0.5 to 1 part of caprylic / capric triglyceride (ODO), 0.001 to 0.003 part of vitamin E, and 2 to 5 parts of emulsifier. The coenzyme Q10 and octacosanol compounded type nanostructure lipid carrier is compounded by the coenzyme Q10 and the octacosanol, and has the characteristics that the functions of reducing blood fat, protecting the heart and the like are realized, the releasing degree and bioavailability are higher, and the effect of sustained release is realized.

Description

technical field [0001] The present invention relates to a kind of coenzyme Q 10 A nanostructured lipid carrier compounded with octacosanol and a preparation method thereof, the nanostructured lipid carrier has the functions of enhancing immunity, relieving physical fatigue, protecting the heart, etc., and belongs to the technical field of medicines and health care products. Background technique [0002] coenzyme Q 10 (Coenzyme Q 10 ) is a compound synthesized by the human body. It is named for its side chain-polyisoprenyl at the six-position of the mother nucleus with a degree of polymerization of 10, and its structure is similar to vitamin K. coenzyme Q 10 reduced coenzyme Q 10 (Co Q 10 h 2 , Ubiquinol, ubiquinol) and oxidized coenzyme Q 10 (Co Q 10 , Ubiquinone, ubiquinone) two forms, CoQ 10 h 2 is Co Q 10 the two-electron reducer. In vivo, Co Q 10 h 2 with CoQ 10 As a type of hydrogen-donating / electron-donating body, it participates in transmembrane electro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/36A61K31/122A61K31/045A61P37/04A61P39/00A61P9/00A61P3/06A61P39/06
CPCA61K31/045A61K31/122A61K47/36A61K2300/00
Inventor 董英杰艾莉李晓怡邹晓峰韩亚男丁爽东长青许永超
Owner SHENYANG WANJIA INST OF BIOLOGICAL TECH RES
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