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Composition for preventing hair loss or stimulating hair growth comprising sophorolipid as effective component

An active ingredient and anti-hair loss technology, which is applied in the direction of medical preparations containing active ingredients, organic active ingredients, drug combinations, etc., can solve the problems of undisclosed anti-hair loss or hair growth promotion compositions, etc., to prevent hair loss and improve hair loss , the effect of reducing the amount of hair removal

Active Publication Date: 2018-06-05
BIO INTERCHANGE CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, no anti-hair loss or hair growth-promoting composition comprising the sophorolipid of the present invention as an active ingredient has been disclosed so far.

Method used

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  • Composition for preventing hair loss or stimulating hair growth comprising sophorolipid as effective component
  • Composition for preventing hair loss or stimulating hair growth comprising sophorolipid as effective component
  • Composition for preventing hair loss or stimulating hair growth comprising sophorolipid as effective component

Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0040] Preparation example 1. preparation of sophorolipids of the present invention

[0041] 1) Preparation of fatty acids (methyl esterification) using vegetable oil mixtures

[0042] In order to prepare methyl-esterified fatty acids, generally, according to the common preparation procedures in this technical field, a mixture of sunflower seed oil, camellia oil and palm oil is used as fatty acids with different carbon lengths, and 500 ml of After methanol and 8.2ml of sulfuric acid, use a sterilizer at 100°C and high pressure (0.3kgf / cm 2 ) was reacted for 2 hours, and then in order to obtain only the methyl esterified fatty acid, after adding hexane to separate the layers, the solvent was removed using a rotary evaporator to obtain a methyl esterified substrate.

[0043] 2) Preparation of fatty acid (methyl esterification) using coconut oil

[0044] In order to prepare methyl-esterified fatty acid, coconut oil was used as fatty acid, and after adding 500ml of methanol and ...

Embodiment 1

[0050] Example 1. Human dermal papilla cell growth-promoting effect of processing the sophorolipid of the present invention

[0051] In cultured human dermal papilla cells (human dermal papilla cells, hDPC), the yeast culture broth prepared in Preparation Example 1 above using fatty acids derived from a mixture of sunflower seed oil, camellia oil, and palm oil was treated to extract and not purify The unpurified sophorolipids and the purified sophorolipids were extracted from the yeast culture broth cultivated with fatty acids derived from coconut oil for 48 hours, and analyzed by water-soluble tetrazolium salt method (water-soluble tetrazolium salt-1assay, WST-1) cell growth. The normal group refers to untreated human dermal papilla cells, and the positive control group is the minoxidil component that has been used to prevent hair loss and has proven hair growth efficacy and is sold in the market. As a result, as shown in the following Table 2, compared with the normal group...

Embodiment 2

[0058] Embodiment 2. Animal model experiments for the hair growth effect of sophorolipids of the present invention

[0059] In order to confirm the hair loss symptom-improving effect of the sophorolipid of the present invention, 6-week-old female C57BL / 6 mice having the genetic characteristic of spontaneous hair loss, which are commonly used as animal models, were used. Taking female C57BL / 6 mice as objects, use electric clipper cut for the first hair removal, apply shaving cream (shaving form), and use a razor (shaving razor) from the back to the beginning of the tail The length and vertical direction of the body are based on the midline, and the left and right widths of more than 1 cm are removed for the second time, and only individuals with uniform pink skin color on the back are selected for use in the experiment. After placing a brush on the hair-removed area, 200 μl of the test substance was dispensed to the tip of the brush with a micropipette, and then applied to all ...

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Abstract

The present invention relates to a composition containing sophorolipid as an active ingredient for preventing hair loss or promoting hair growth. According to the present invention, sophorolipid, which is a non-toxic and biodegradable natural surfactant derived from microbes, is environmentally friendly, and sophorolipid, when treated on hair papilla cells, exhibits a growth promotion effect of the hair papilla cells, remarkably decreases the number of shed hairs, and shows a hair growth promotion effect, and thus can be favorably used as a cosmetic agent or externally-applied dermal preparation for preventing hair loss, relieving hair loss, treating hair loss, or promoting hair growth.

Description

technical field [0001] The present invention relates to a composition for preventing hair loss or promoting hair growth comprising sophorolipid as an active ingredient. Background technique [0002] There are about 100,000 to 150,000 human hairs, and each hair has a different hair cycle. It grows and falls through repeated growth phases (anagen), degenerative phases (catagen) and resting phases (telogen). As a result, about 15% of all hairs are in the telogen and catagen phases, and an average of 50 to 100 hairs are normally shed and regenerated per day. The growth cycle of this hair is repeated in a cycle of about 3 to 6 years. Generally, alopecia refers to that the period corresponding to the anagen (anagen) of the hair cycle is shortened for various reasons and the ratio of the catagen and telogen hairs is relatively increased, and the number of hair loss is increased compared with the average value, which The cause has the effect of genetic androgen, malnutrition based...

Claims

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Application Information

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IPC IPC(8): A61K8/60A61Q7/00A61K31/7048A61K31/7028A61P17/14
CPCA61K8/60A61K9/0014A61K31/7028A61K31/7048A61Q7/00A61K2300/00A61K8/02A61K8/92A61Q5/00A61Q5/02A61Q5/04A61Q5/06A61Q5/08A61Q5/12A61P17/14A61K8/602A61K8/922
Inventor 金春植金承泽金大淳金惠文
Owner BIO INTERCHANGE CO
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