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Preparation method for liquid-filled pellet capsule with weight-reducing and health-care functions

A technology for liquid-filled capsules and pellets is applied in the field of preparation of micro-pill liquid-filled capsules, which can solve the problems of metabolic disorder, excessive concentration of serum functional components, and impact on health, etc., and achieves easy operation, protection effectiveness, and good roundness. Effect

Active Publication Date: 2018-06-12
BEIJING COMPETITOR SPORTS SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, after taking slimming capsules, the concentration of serum functional components will rise rapidly within a period of time, which may cause the concentration of serum functional components to exceed the standard. If this happens for a long time, it will cause the body's metabolism to be disordered and affect health problems.

Method used

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  • Preparation method for liquid-filled pellet capsule with weight-reducing and health-care functions
  • Preparation method for liquid-filled pellet capsule with weight-reducing and health-care functions
  • Preparation method for liquid-filled pellet capsule with weight-reducing and health-care functions

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] 1.1. Vitamin and mineral pellets: 1) Take blank starch pellet cores between 60 mesh and pour them into the fluidized bed, turn on the blower, heat the material so that the temperature of the material is preheated at 40°C, and the air flow is controlled at 2.5m 3 / m, the speed of the turntable is 600rpm, so that the fluidization of the blank ball core is uniform; 2) Turn on the peristaltic pump, control the microcrystalline cellulose flow rate to 50-100ml / min, add 300 grams of vitamin and mineral premixes through a 60-mesh sieve In the process, the powder feeding rate is 25g / min, and the pellets are enlarged until the powder is added. Continue to fluidize for 5 minutes, and dry at 400C to get it.

[0040] 1.2. Functional ingredient pellets

[0041] Mix 300 grams of L-carnitine tartrate, 25 grams of kelp extract, 25 grams of green tea extract, and 5 grams of microcrystalline cellulose, and add 50 grams of HPMC as a binder to prepare a soft material. 5cm strips; 2) adjus...

Embodiment 2

[0045] 2.1. Vitamin and mineral pellets: 1) Mix 300 grams of vitamin and mineral powder with 80 mesh and starch evenly, add 2% polyvinylpyrrolidone solution to make soft material, pass through a 60 mesh sieve to obtain wet granules, and place them in shot blasting In the machine, adjust the blast frequency at 8-15HZ, the turntable frequency at 10-30HZ, throw round for 3-5min, after forming pellets with uniform size, discharge the pellets, and fluidize and dry them.

[0046] 2.2. Functional ingredient pellets

[0047] Mix 300 grams of L-carnitine tartrate, 25 grams of kelp extract, 25 grams of green tea extract, and 5 grams of microcrystalline cellulose, and add 50 grams of HPMC as a binder to prepare a soft material. 5cm strips; 2) adjust the rotating speed of the turntable at the bottom of the shot blasting machine, and use 85% ethanol solution as a wetting agent to make the strips fluidize and spheronize in the fluidized bed for about 8-10 minutes, dry, and properly sieve. ...

Embodiment 3

[0052] 3.1. Vitamin and mineral pellets: 1) Pass 300 grams of vitamin and mineral premix through an 80-mesh sieve, mix evenly with 5 grams of microcrystalline cellulose, add an appropriate amount of purified water to make a soft material, and pass through a 20-mesh sieve. Put the wet particles in the shot blasting machine, adjust the blast frequency at 8-15HZ, the turntable frequency at 10-30HZ, throw round for 3-5min, and after the pellets with uniform size are formed, discharge the material and fluidize and dry it. . ;

[0053] 3.2. Functional ingredient pellets

[0054] 300 grams of L-carnitine tartrate, 30 grams of kelp extract, 30 grams of green tea extract, and 8 grams of microcrystalline cellulose are mixed evenly, and 50 grams of HPMC are added to prepare a soft material. 5cm strips; 2) adjust the rotating speed of the turntable at the bottom of the shot blasting machine, and use 85% ethanol solution as a wetting agent to make the strips fluidize and spheronize in th...

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Abstract

The invention relates to a preparation method for a liquid-filled pellet capsule with weight-reducing and health-care functions. The preparation method comprises the following steps: (1) vitamin-mineral pellets are prepared; (2) functional ingredient pellets are prepared; (3) pellet coating is prepared; (4) medium chain triglyceride and conjugated linoleic acid are dissolved by using water-solubleexcipient, so that mixture liquid 1 is obtained; (5) the mixture liquid 1 is mixed with silicon dioxide, glutin and water, so that mixture liquid 2 is obtained; (6) the prepared pellets are added with the mixture liquid 2 and an antioxidant and mixed, so that a liquid-filled capsule content is obtained; (7) a hollow capsule is filled with the liquid-filled capsule content. The pellets prepared bythe preparation method disclosed by the invention have the advantages of good roundness, moderate hardness and high yield. Moreover, the compound preparation obtained by the invention not only can prevent the interaction between medicines, but also can increase the stability of the preparation. The process of the method is simple and easy to operate.

Description

technical field [0001] The invention belongs to the technical field of preparations, and in particular relates to a preparation method of micropill liquid-filled capsules with functions of weight loss and health care. Background technique [0002] When most people lose weight, the absorption of vitamins and minerals is affected by single food intake or too little fat intake, resulting in a lack of vitamins and minerals in the body. Vitamins and minerals are micronutrients needed by organisms, but generally they cannot be produced by organisms themselves, and must be obtained through diet and other means. Vitamins and minerals cannot produce energy and form cells like carbohydrates, proteins and fats, but they regulate the metabolism of organisms. Vitamin mineral deficiencies can lead to serious health problems, and adequate intake of vitamins and minerals can keep the body strong and healthy. Therefore, it is necessary to prepare a weight loss product that should not only ...

Claims

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Application Information

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IPC IPC(8): A61K45/06A61K36/82A61K9/48A61K9/50A61P3/04A61P3/02A61K31/205A61K36/03
CPCA61K9/5005A61K9/5084A61K31/205A61K36/03A61K36/82A61K45/06A61K2300/00
Inventor 李奇庚魏冰曹珍艳
Owner BEIJING COMPETITOR SPORTS SCI & TECH
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