Iron-based catalyst for synthesizing compound with quinazolinone structure, and preparation method and application of iron-based catalyst

An iron-based catalyst, quinazolinone technology, applied in physical/chemical process catalysts, chemical instruments and methods, chemical/physical processes, etc., can solve the problems affecting product quality, catalysts cannot be recycled, and product separation is complicated, etc. Achieving the effects of wide substrate applicability, good catalyst stability and high product selectivity

Active Publication Date: 2018-06-12
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Although the above synthetic methods can effectively obtain the target product, all systems are homogeneous reaction systems, which have the following disadvantages: the catalyst cannot be recycled, the product separation is complicated, and the remaining trace metals in the transition metal catalytic system will affect the product. quality (especially for medicine), etc.

Method used

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  • Iron-based catalyst for synthesizing compound with quinazolinone structure, and preparation method and application of iron-based catalyst
  • Iron-based catalyst for synthesizing compound with quinazolinone structure, and preparation method and application of iron-based catalyst
  • Iron-based catalyst for synthesizing compound with quinazolinone structure, and preparation method and application of iron-based catalyst

Examples

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Effect test

Embodiment 1

[0031] Weigh 1g of anhydrous ferric chloride and 0.9g of 1-ethyl-3-methylimidazolium chloride salt into acetone, stir at room temperature for 3 hours to obtain a mixed solution; then add 10g of sucrose to the above mixed solution, and Stir at low temperature for 12 hours, then spin evaporate the acetone, dry the obtained solid under vacuum at 60°C for 12 hours, heat it to the target temperature of 600°C in an inert atmosphere, pyrolyze it at a constant temperature for 2 hours, and then cool it down to room temperature naturally to obtain a black powder that is ready for use. Iron-based catalysts for the synthesis of quinazolinone compounds.

Embodiment 2

[0033] Weigh 1g of anhydrous ferric chloride and 0.9g of 1-ethyl-3-methylimidazolium chloride salt into acetone, stir at room temperature for 3 hours to obtain a mixed solution; then add 10g of sucrose to the above mixed solution, and Stir at low temperature for 12 hours, then spin evaporate the acetone, and dry the obtained solid under vacuum at 60°C for 12 hours. After heating to the target temperature of 700°C in an inert atmosphere, pyrolyze at constant temperature for 2 hours, and then cool naturally to room temperature to obtain a black powder that is ready for use. Iron-based catalysts for the synthesis of quinazolinone compounds.

Embodiment 3

[0035] Weigh 1g of anhydrous ferric chloride and 0.9g of 1-ethyl-3-methylimidazolium chloride salt into acetone, stir at room temperature for 3 hours to obtain a mixed solution; then add 10g of sucrose to the above mixed solution, and Stir under low temperature for 12 hours, then spin evaporate the acetone, and dry the obtained solid under vacuum at 60°C for 12 hours, heat it to the target temperature of 800°C in an inert atmosphere, pyrolyze it at a constant temperature for 2 hours, and then cool it down to room temperature naturally to obtain a black powder that is ready for use. Iron-based catalysts for the synthesis of quinazolinone compounds.

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Abstract

The invention belongs to the technical field of liquid phase oxidation, and discloses an iron-based catalyst for synthesizing a compound with a quinazolinone structure, and a preparation method and application of the iron-based catalyst. The iron-based catalyst mainly consists of carbon and nitrogen elements, wherein the weight ratio of various elements is as follows: 5-10 wt% of iron, 55-70 wt% of carbon and 1-20 wt% of nitrogen, and the particle size of the iron nano particles of the iron-based catalyst is 5-20 nm. The iron-based catalyst is prepared by taking a magnetic ion liquid as a precursor and sucrose as a carbon source, and carrying out pyrolysis in an inert atmosphere. In the presence of the iron-based catalyst in a very low usage amount, peroxide used as an oxidant and no otheradditives, the quinazolinone compound is synthesized by taking anthranilamide compounds and primary alcohols as raw materials. The iron-based catalyst provided by the invention is easy to synthesizemassively, has magnetism, can be recycled, and has the advantages of mild reaction condition, greenness, environmental protectiveness, easy separation of products, high selectivity and yield of products, and a good application prospect.

Description

technical field [0001] The invention belongs to the technical field of liquid-phase catalytic oxidation, and relates to an iron-based catalyst, in particular to an iron-based catalyst for synthesizing quinazolinone structural compounds, a preparation method and application thereof. Background technique [0002] Quinazolinone compounds are an important nitrogen-containing heterocyclic compound. Usually, compounds containing quinazolinone structures exhibit certain biological and pharmacological activities, such as anti-tumor, anti-hypertensive, anti-inflammatory, and bactericidal. Show good pharmacological activity. In terms of pesticides, quinazolinone compounds are mainly used as insecticides, fungicides, and herbicides. Therefore, the synthesis of quinazolinone compounds has always been the focus of attention in the fields of biology, chemistry and pharmacy, and it is also one of the hot topics in the research of organic synthesis and other fine chemical fields. [0003]...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J27/24C07D239/91C07D239/90C07D405/04
CPCB01J27/24C07D239/90C07D239/91C07D405/04Y02P20/584
Inventor 高爽王连月吕迎
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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