Preparation method and application of anticoagulant and anti-adhesion polyheptafluorobutyl acrylate-polycaprolactone block polymer nanofiber membrane

A technology of polyheptafluorobutyl acrylate and heptafluorobutyl acrylate, which is applied in anticoagulation treatment, fiber treatment, pharmaceutical formulations, etc., and can solve the problem of affecting the anticoagulation effect and biocompatibility of biological materials, modification or modified group uneven distribution, high production cost, etc., to achieve the effect of improving blood compatibility, controllable degradation, and low cost

Active Publication Date: 2018-06-15
THE FIRST AFFILIATED HOSPITAL OF ARMY MEDICAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] The preparation of most anticoagulant biomaterials without anticoagulants is mainly made by chemically modifying or modifying the surface of the material, but the above-mentioned process is complicated and the production cost is high; at the same time, the surface modification or modification of biomaterials is both Treatment of solid surfaces usually leads to uneven distribution of modified or modified groups, which further affects the anticoagulant effect and biocompatibility of biological materials

Method used

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  • Preparation method and application of anticoagulant and anti-adhesion polyheptafluorobutyl acrylate-polycaprolactone block polymer nanofiber membrane
  • Preparation method and application of anticoagulant and anti-adhesion polyheptafluorobutyl acrylate-polycaprolactone block polymer nanofiber membrane
  • Preparation method and application of anticoagulant and anti-adhesion polyheptafluorobutyl acrylate-polycaprolactone block polymer nanofiber membrane

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Embodiment 1

[0034] Embodiment 1: A kind of preparation method of anticoagulant anti-adhesion polyheptafluorobutyl acrylate-polycaprolactone block polymer nanofiber membrane comprises the following steps:

[0035](1) Synthesis of trithiocarbonate-terminated polycaprolactone: 5g polycaprolactone and 0.182g S-dodecyl-S'-(α,α'-dimethyl-α"-acetic acid ) Trithiocarbonate was put into a 100mL flask, and heated under vacuum at 80°C for 2 hours to remove moisture. Then add 30mg dimethylaminopyridine and 95mg 1-(3-dimethylaminopropyl)-3-ethylcarbodi imine hydrochloride) was degassed by bubbling in nitrogen for 20min, and 60mL of anhydrous dichloromethane was added under nitrogen protection. After the polycaprolactone was dissolved, the solution was stirred at 40°C for 2 days, and the product was precipitated with 300mL of methanol , the product was redissolved in dichloromethane and precipitated again, repeated twice, and the resulting final product was collected by vacuum drying;

[0036] (2) Syn...

Embodiment 2

[0040] Embodiment 2: A method for preparing an anticoagulant and anti-adhesion polyheptafluorobutyl acrylate-polycaprolactone block polymer nanofiber membrane, comprising the following steps:

[0041] (1) Synthesis of trithiocarbonate-terminated polycaprolactone: 2 g of polycaprolactone and 72.8 mg of S-dodecyl-S'-(α,α'-dimethyl-α"-acetic acid ) Trithiocarbonate was put into a 50mL flask, and heated under vacuum at 70°C for 4 hours to remove moisture. Then add 12mg dimethylaminopyridine and 32mg 1-(3-dimethylaminopropyl)-3-ethylcarbodi imine hydrochloride) was degassed by bubbling in nitrogen for 20 minutes, and 20 mL of anhydrous dichloromethane was added under nitrogen protection. After the polycaprolactone was dissolved, the solution was stirred at room temperature for 2 days, and the product was precipitated with 100 mL of ethanol. The product was redissolved in dichloromethane and precipitated again, repeated twice, and the final product was collected under vacuum drying;...

Embodiment 3

[0045] Embodiment three: a kind of preparation method of anticoagulant antiadhesion polyheptafluorobutyl acrylate-polycaprolactone block polymer nanofiber membrane, comprises the following steps:

[0046] (1) Synthesis of trithiocarbonate-terminated polycaprolactone: 5g polycaprolactone and 0.182g S-dodecyl-S'-(α,α'-dimethyl-α"-acetic acid ) trithiocarbonate into a 100mL flask, heated at 60°C under vacuum for 6 hours to remove moisture. Then add dimethylaminopyridine and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide Hydrochloride) was degassed by bubbling in nitrogen for 20min, and 60mL of anhydrous dichloromethane was added under nitrogen protection. After the polycaprolactone was dissolved, the solution was stirred at 30°C for 2 days, and the product was precipitated with isopropanol. The product was redissolved in dichloromethane and precipitated again, repeated twice, and the final product was collected under vacuum drying;

[0047] (2) Synthesis of hydrophobic polyheptaf...

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Abstract

Belonging to the field of biological materials, the invention in particular relates to a preparation method and application of an anticoagulant and anti-adhesion polyheptafluorobutyl acrylate-polycaprolactone block polymer nanofiber membrane. The method includes: using a 2, 2, 3, 3, 4, 4, 4-heptafluorobutyl acrylate monomer to connect a fluorine-containing polymer chain segment to a polycaprolactone macromolecular chain end by reversible addition fragmentation chain transfer process to form a polyheptafluorobutyl acrylate-polycaprolactone block polymer, and subjecting the polyheptafluorobutylacrylate-polycaprolactone block polymer to electrostatic spinning, thus obtaining the polyheptafluorobutyl acrylate-polycaprolactone block polymer nanofiber membrane. The method is simple and practicable, the prepared nanofiber membrane has good blood compatibility, and excellent anticoagulant and anti-adhesion effects, and has enormous application potential in preparation of medical dressings orstents contacting blood.

Description

technical field [0001] The invention belongs to the field of biological materials, and in particular relates to a preparation method and application of an anticoagulant and antiadhesion polyheptafluorobutyl acrylate-polycaprolactone block polymer nanofiber membrane. Background technique [0002] Thromboembolic disease has become the most dangerous and deadly disease in human life. Platelet adhesion and aggregation is the "culprit" of thrombus formation by forming clots in blood vessels that block blood flow. Any foreign material such as blood vessels, stents or organs that come into contact with blood after implantation will trigger a series of complex interactions (such as protein adsorption, platelet adhesion, activation and aggregation, blood coagulation system and complement system activation, etc.) to form thrombus. Short- and long-term anticoagulants, such as heparin and argatroban, are often used to prevent thrombosis. Combining anticoagulants with biomaterials can ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/42A61L15/26A61L31/06A61L31/14A61L33/06A61L33/00C08F293/00C08F220/22D01D5/00D04H1/728
CPCA61L15/26A61L15/42A61L31/06A61L31/14A61L33/0005A61L33/068A61L2400/18C08F220/22C08F293/005C08F2438/03D01D5/003D04H1/728C08L53/00
Inventor 王颖罗高兴邢孟秋刘梦龙贺伟峰刘雨青钱卫王淞
Owner THE FIRST AFFILIATED HOSPITAL OF ARMY MEDICAL UNIV
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