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Repairing fusion type heart stent and manufacturing method thereof

A heart and skeleton technology, applied in the field of medical materials, can solve the problems of intravascular atherosclerotic plaque fragmentation and shedding, coronary heart disease attack again, late stent thrombosis, etc., to solve the problem of dissolving blockage and shedding, eliminating rejection inflammation, The effect of regeneration

Inactive Publication Date: 2018-06-22
付静
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Compared with drug therapy and surgical treatment, interventional therapy for coronary heart disease has the advantages of significant therapeutic effect, small surgical trauma, and easy promotion of technology. , Complications that are prone to occur with the existing stents are mainly manifested in postoperative inflammation at the contact point of the vascular stent, regeneration of the vessel wall leading to restenosis, induction of thrombus leading to recurrent coronary heart disease attack, and even acute myocardial infarction. The existing organic stents are easy to Late thrombosis and very late thrombosis problems caused by the elastic retraction of expanded blood vessels, the crushing and falling off of atherosclerotic plaques in blood vessels, or the oxidative degradation or even dissolution of stents

Method used

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  • Repairing fusion type heart stent and manufacturing method thereof
  • Repairing fusion type heart stent and manufacturing method thereof
  • Repairing fusion type heart stent and manufacturing method thereof

Examples

Experimental program
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Embodiment 1

[0025] Such as Figure 1-3 As shown, the present invention provides a stent for repairing a fusion type heart, which is composed of a stent skeleton 1, a skeleton opening 2, a skeleton inner layer 3, and a skeleton outer layer 4. The wall thickness of the bracket belongs to 40-65 nanometers.

[0026] The frame of the stent is made of fluorocarbon silicon and fusion materials. The openings of the frame are open at both ends, such as the opening 21 and the opening 22. The outer layer of the frame is inhibiting and repairing drugs. The layer is antithrombotic drugs, the outer layer is coated on the skeleton, the inner layer is polymerized on the skeleton, and the scaffold is a mesh structure such as an elliptical polygonal mesh (see figure 1 ), quadrilateral (see image 3 )Wait.

[0027] The skeleton is a flexible and elastic material with a certain strength suitable for the human body, which is formed by the polymerization of fluorine-modified carbon-silicon materials and fus...

Embodiment 2

[0033] Such as Figure 1-3 Shown on the basis of Example 1, a more preferred embodiment of the present invention will be described below. The present invention provides a stent for repairing a fusion type heart, such as figure 2 As shown, the appearance of its skeleton is an elliptical polygonal mesh. The fluorocarbon silicon material and the fusion type material are made of acrylic acid fluoroalkyl acetate skeleton material, and the thickness of the skeleton is 32nm to achieve its strength and toughness. The antithrombotic drug of the polymer in layer 3 is a chain or cyclic isodiene diterpene derivative, the thickness of the inner layer 3 is 6nm, and the outer layer 4 of the skeleton is an adhesive antithrombotic drug: pentamycin, Paint substances such as acetylspiramycin and tacrolimus, the thickness of the outer layer 4 is 2nm, the openings 21 and 22 at both ends have a diameter of 2mm, and the two ports 2 and the elliptical polygonal mesh The surface of the structure is ...

Embodiment 3

[0038] Such as Figure 1-3 Shown on the basis of Example 1, a more preferred embodiment of the present invention will be described below. The present invention provides a stent for repairing a fusion type heart, such as image 3 As shown, the appearance of its skeleton is a quadrilateral network, and the fluorocarbon silicon material and the fusion type material are made of fluoroalkyl lactate skeleton material, and the thickness of the skeleton is 50nm, so as to realize its elasticity and melt toughness. The inner layer of the skeleton is 3 The polymer inhibitory antithrombotic drugs are paclitaxel analogues,

[0039] Paclitaxel is described below. Paclitaxel is a broad-spectrum anti-cancer and cell-repair drug extracted from the bark of the yew tree. It has attracted the attention of the chemical and medical circles because of its novel chemical structure and unique anti-tumor mechanism of repair cells. In order to reduce The toxic and side effects of paclitaxel, improve it...

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Abstract

The invention relates to a heart stent and a manufacturing method thereof in the medical field. The heart stent is specifically composed of a stent framework, a framework opening, a framework inner layer and a framework outer layer. The stent framework is made of fluorocarbon silicon and fusion materials. The framework opening is of a two-end opened type. The framework outer layer is made of a repairing restraining medicine, and the framework inner layer is made of a thrombus restraining and resisting medicine. The framework is coated with the outer layer, and the inner layer is polymerized onthe framework. The stent is of a mesh-shaped structure. Thus, the stent has high strength and softness, the structural design reasonably conforms to human mechanics, flexibility is high, blood vesselcompatibility is high, supporting and dredging performance is stable, and the heart stent has good cell repairing and disease symptom treating effects and has wide application range on the aspect ofcardiovascular diseases.

Description

technical field [0001] The invention relates to the field of medical materials, in particular to a heart stent and a manufacturing method thereof. Background technique [0002] Coronary heart disease is a disease in which atherosclerosis occurs in the walls of coronary arteries that supply myocardial blood, resulting in stenosis or even complete blockage of the vessel lumen, causing myocardial ischemia, hypoxia, or even necrosis. With the improvement of people's living standards and the increase of the elderly population, the incidence of coronary heart disease is on the rise. Percutaneous coronary intervention (PCI) is the main method for the treatment of coronary heart disease. According to statistics, more than 85% of patients undergoing PCI now have implanted stents. It has become the most important measure to ensure the treatment effect of coronary heart disease to select the appropriate cardiac stent implanted in the patient's blood vessel. Compared with drug therapy...

Claims

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Application Information

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IPC IPC(8): A61F2/90A61M31/00A61L31/16
CPCA61F2/90A61L31/16A61L2300/41A61L2300/412A61L2300/416A61L2300/42A61M31/002
Inventor 付静林燕李晓红杨璞王洪光
Owner 付静
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