Self-repairing hydrogel based on di-selenium dynamic covalent bond and quadruple hydrogen bond

Abstract

The invention discloses a preparation method of a self-repairing hydrogel based on double-selenium dynamic covalent bond and quadruple hydrogen bond. The hydrogel is prepared from the following steps:enabling the diisocyanate, polyethylene glycol, di-selenium diol, UPy-based chain extender and crosslinking agent trimethylolpropane to react in tetrahydrofuran to obtain organic gel, and soaking theorganic gel in deionized water to remove the solvent and unreacted micromolecule. The hydrogel can realize the repeatable fast self-repairing on the injury under the mild visible irradiation based onthe dynamic feature of the di-selenium dynamic covalent bond under the visible irradiation and the UPy quadruple hydrogen bond fast fracturing-recombining feature, the damage on the material structure by the high-temperature, ultraviolet irradiation and other stronger external stimulus required by the traditional self-repairing is avoided. The hydrogel is a polyurethane structure taking the polyethylene glycol as the hydrophilia soft segment, and has excellent biocompatibility and molecular structure designability; the actual application requirement can be well satisfied, and the hydrogel hasa extensive application prospect in the field of the biological tissue engineering.

Description

technical field

[0001] The invention relates to a preparation method of a self-repairing hydrogel, in particular to the preparation of a self-repairing polyurethane hydrogel based on the joint action of double selenium dynamic covalent bonds and hydrogen bonds. Background technique

[0002] Hydrogel is a polymer material with a three-dimensional network structure that is physically or chemically cross-linked. It uses water as a dispersion medium and can absorb a large amount of water to swell and maintain its structural stability. As a material with high water absorption and high water retention, hydrogel has been widely used in the fields of industry, agriculture and biological tissue engineering. However, in practical applications, due to the single or combined effects of external forces, light, heat, and chemicals, traditional hydrogels will produce microcracks inside that are difficult to detect and repair. The expansion and increase of these microcracks will reduce the...

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