Adhesive for cataract surgery incision and preparation method thereof

A surgical incision and adhesive technology, which is applied in the direction of surgery, surgical adhesives, applications, etc., can solve the problems of corneal irritation, poor bio-glue degradation performance, and long residence time on the eye surface, so as to prevent hypotension ophthalmia and reduce risks , the effect of preventing bacterial infection

Active Publication Date: 2021-01-22
沈阳百奥医疗器械有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Bio-glue has a good sealing effect on the wound, and can maintain the front internal pressure and stable state for a long time, but the bio-glue has poor degradation performance and stays on the surface of the eye for a long time, which will cause additional stimulation to the cornea and affect the repair of surgical wounds

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Dissolve chitosan and gelatin with a number average molecular weight of 12w in a trifluoroacetic acid solution according to a mass ratio of 7:3, slowly stir until completely dissolved, then add a 30% trifluoroacetic acid solution volume in dichloromethane solution to make the spinning solution The concentration of the solution is 10%, stir slowly and fully dissolve the solution, seal the solution, and let it stand at 4°C for 24 hours to remove the bubbles in the solution for later use;

[0029] Fill the obtained spinning solution into a syringe, the diameter of the needle at the front end of the syringe is 0.7 mm, connect the needle of the chitosan syringe to the positive electrode of the electrospinning machine, and the negative electrode of the drum-shaped receiver electrospinning machine to adjust the electrospinning The distance between the positive and negative electrodes of the machine is 10cm, the positive and negative voltage difference is 30kv, the rotational sp...

Embodiment 2

[0033]Dissolve chitosan and gelatin with a number-average molecular weight of 25w in a trifluoroacetic acid solution at a mass ratio of 7:3, stir slowly and add 30% trifluoroacetic acid solution volume in dichloromethane solution after completely dissolving to make the spinning solution The concentration of the solution is 10%, stir slowly and fully dissolve the solution, seal the solution, and let it stand at 4°C for 24 hours to remove the bubbles in the solution for later use;

[0034] Fill the obtained spinning solution into a syringe, the diameter of the needle at the front end of the syringe is 0.7 mm, connect the needle of the chitosan syringe to the positive electrode of the electrospinning machine, and the negative electrode of the drum-shaped receiver electrospinning machine to adjust the electrospinning The distance between the positive and negative electrodes of the machine is 7cm, the positive and negative voltage difference is 25kv, the rotational speed of the rece...

Embodiment 3

[0038] Dissolve chitosan and gelatin with a number average molecular weight of 38w in a trifluoroacetic acid solution according to a mass ratio of 7:3, stir slowly and add 30% trifluoroacetic acid solution volume in dichloromethane solution after completely dissolving to make the spinning solution The concentration of the solution is 15%, and the solution is sealed after being stirred slowly and fully dissolved, and left to stand at 4°C for 24 hours to remove the air bubbles in the solution for later use;

[0039] Fill the obtained spinning solution into a syringe, the diameter of the needle at the front end of the syringe is 0.7 mm, connect the needle of the chitosan syringe to the positive electrode of the electrospinning machine, and the negative electrode of the drum-shaped receiver electrospinning machine to adjust the electrospinning The distance between the positive and negative electrodes of the machine is 10cm, the positive and negative voltage difference is 20kv, the ...

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PUM

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Abstract

The invention provides an adhesive for cataract surgery incision. The adhesive for cataract surgery incision is obtained by performing vacuum freeze drying on a chitosan electrostatic spinning film. The invention also provides a preparation method of the adhesive for cataract surgery incision. The chitosan electrostatic spinning film is subjected to vacuum freeze drying to serve as the adhesive for cataract surgery incision; and the chitosan electrostatic spinning film encounters water to form a viscous film, has a certain viscidity and tension, can prevent aqueous humor from flowing out through a cataract surgery wound, can maintain anterior chamber pressure for a long time and can prevent low-pressure eye disease. The chitosan electrostatic spinning film is a water-soluble film, can be degraded in a cornea slowly, can flow out along with tear to separate from the cornea, does not need to be treated and eliminated and avoids secondary damage to the cornea. The experiment result indicates that the adhesive provided by the invention can prevent aqueous humor from flowing out and can maintain the anterior chamber pressure to stabilize for 1 to 2 days when being used for sealing the cataract surgery incision.

Description

technical field [0001] The invention relates to the technical field of cataract treatment, in particular to an adhesive for cataract surgery incision and a preparation method thereof. Background technique [0002] Cataract is a common senile disease, which is caused by various reasons such as aging, genetics, local nutritional disorders, immune and metabolic abnormalities, trauma, poisoning, radiation, etc., which cause lens metabolic disorders, resulting in lens protein denaturation and turbidity. At present, cataract is mainly treated with phacoemulsification. The patient’s eye is cut through the scleral tunnel at 12 o’clock. Capsulorhexis forceps remove the anterior capsule of the diseased lens through the incision, expose the diseased lens, remove the diseased lens by phacoemulsification, and implant an intraocular lens. achieve the purpose of treatment. Because the anterior humor leaks out of the cataract corneal incision, the intraocular pressure of the anterior chamb...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L24/08A61L24/10D04H1/728D01D5/00
CPCA61L24/001A61L24/0042A61L24/043D01D5/0015D04H1/728C08L89/06C08L5/08
Inventor 王卓实郑玉强
Owner 沈阳百奥医疗器械有限公司
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