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Composition containing fish eyes and gamma-aminobutyric aids and capable of alleviating asthenopia

A technology for relieving visual fatigue and aminobutyric acid, applied in the field of medicine and health, can solve the problems of inattention, memory loss, and ineffective improvement of local symptoms of the eye, etc., to achieve a broad market prospect and improve the effect of mental and neurological symptoms

Inactive Publication Date: 2018-07-06
成都图径生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, the products on the market to improve visual fatigue usually only target blue light damage itself, and have no obvious improvement effect on local eye symptoms, and cannot solve other symptoms caused by different degrees of visual fatigue, such as inattention, memory loss, etc.

Method used

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  • Composition containing fish eyes and gamma-aminobutyric aids and capable of alleviating asthenopia
  • Composition containing fish eyes and gamma-aminobutyric aids and capable of alleviating asthenopia
  • Composition containing fish eyes and gamma-aminobutyric aids and capable of alleviating asthenopia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Example 1 Manufacture of fish eyeball extracts (with DHA as an index component) such as tuna, tuna, bonito, horse mackerel, tilapia

[0044] Raw material processing: take the fish eye (eyeball tissue) of fresh sea fish, wash it with water, drain it, soak it in 0.05-0.1% citric acid solution for 10-30min, dry it at 40-70°C until the water content is less than 4%, and then Grinding to 100-200 mesh sea fish meal;

[0045] Enzymolysis: add buffer solution to the treated sea fish meal and adjust the pH value to 4-6 with 6mol / L hydrochloric acid, add mass fraction 0.1-1.0%, enzyme activity 3.0×10 4 u / g papain and mass fraction 0.5-1.5%, enzyme activity 1.0×10 4 u / g cellulase, stir and enzymolyze at 40-60°C for 1-2h, then adjust the pH to neutral with 0.5mol / L sodium hydroxide;

[0046] Vacuum extraction: put the obtained marine fish enzymatic hydrolyzate in a vacuum extraction equipment, control the vacuum degree to 85-90KPa, extract at a temperature of 40-60°C for 1-2 hour...

Embodiment 2

[0049] Manufacture of fish eye socket extracts (with DPA, EPA and DHA as index components) such as embodiment 2 tuna, tuna, bonito, horse mackerel, tilapia

[0050] Wash the processed eye sockets of sea fish, add water at a ratio of solid-liquid weight ratio of 1:1-1.2, and then grind it into a slurry to obtain a homogenate; extract the homogenate with an organic solvent for 1-3 times, and mix the organic solvent with the homogenate The ratio of slurry volume is 1:1.2-1.5, collect the extract, and obtain the extract containing DPA, EPA and DHA for future use. The organic solvent refers to petroleum ether or ether; the organic solvent is recovered from the extract to obtain DPA, For the fish oil of EPA and DHA, mix 0.3mol / L sodium methoxide with the same volume of fish oil, fill with nitrogen and stir for 10 minutes at room temperature, adjust the pH value to 7.0-7.2, recover methanol, and obtain methylated fish oil; Molecular distillation of esterified fish oil includes three ...

Embodiment 3

[0051] The preparation of embodiment 3 compositions of the present invention

[0052] Raw material weight ratio: 200-600 parts of fish eye socket tissue pulverization or extract (by weight of fresh product), 200-600 parts of fish eyeball tissue pulverization or extract (by weight of fresh product), γ-aminobutyric acid 100-300 parts, 200-500 parts of phosphatidylserine, 50-200 parts of anthocyanin (or 4-12 parts of astaxanthin, or 1-200 parts of proanthocyanidin), (3R,3'R)-dihydroxy-β - 1-5 parts of carotene, 5-15 parts of lutein and / or lutein ester.

[0053] Preparation:

[0054] 1. The fish eye socket tissue pulverization or extract, fish eye ball tissue pulverization or extract, γ-aminobutyric acid, phosphatidylserine, anthocyanin (or astaxanthin, proanthocyanidin), (3R, 3'R)-dihydroxy-β-carotene and lutein ester are mixed evenly, then added to the syrup and stirred evenly.

[0055] 2. After the injection mold is cooled and formed, it can be made into hard, toffee, sandwi...

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PUM

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Abstract

The invention relates to a composition containing fish eyes and gamma-aminobutyric aids and capable of alleviating asthenopia, and belongs to the field of medicines and health. Active components of the composition capable of alleviating asthenopia provided by the invention comprise fish eye ball tissues or an extract thereof, fish eye socket tissues of an extract thereof, and the gamma-aminobutyric acid. Crowd trial results indicate that the composition is suitable for local symptoms of asthenopia eyes, can obviously alleviate psychoneural symptoms caused by asthenopia in various degrees, suchas inattention and memory decline, is significant in the effect of alleviating asthenopia and has broad market prospects.

Description

technical field [0001] The invention relates to a composition for relieving visual fatigue containing fish eyes and gamma-aminobutyric acid, which belongs to the field of medicine and health. Background technique [0002] Visual fatigue, also known as eye fatigue, is a syndrome based on the subjective symptoms of the patient's eyes, eye or systemic organic factors and mental (psychological) factors. It is not an independent eye disease, so it is often called eye fatigue syndrome. (Refer to: 1. Li Fengming. Chinese Ophthalmology [M]. Beijing: People's Health Publishing House, 2006, 7-8; 2. Qu Hongying et al. Research progress on etiology and treatment of visual fatigue [J]. Chinese Medicine Ophthalmology Journal, 2003, 14(1): 59-61). Mild visual fatigue will cause eye symptoms such as eye soreness and swelling after using the eyes, and will recover soon after rest; moderate visual fatigue will have obvious eye symptoms, which will affect study and work; severe visual fatigue...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/10A23L33/175A61K35/60A61P27/02A61K31/197
CPCA23L33/10A23L33/175A23V2002/00A61K31/197A61K35/60A23V2200/30A23V2200/322A23V2250/038A23V2250/2042A61K2300/00
Inventor 魏巍
Owner 成都图径生物科技有限公司
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