Ankahuangmin (Paracetamol, Caffeine, Cow-bezoar and Chlorphenamine Maleate) oral solution and preparation method thereof

An oral solution, the technology of Amka Huangmin oral solution and its preparation field, can solve the problems of side reaction clarity, oral solution low efficacy, poor absorption effect, etc., to reduce the activity of alanine aminotransferase, shorten the Effective time, improve the effect of drug efficacy

Pending Publication Date: 2018-07-13
JIANGXI HEYING PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In view of this, the main purpose of the present invention is to provide a kind of Ankahuangmin oral solution, which solves the problems in the prior art that the drug has a long residence time in the esophagus, the absorption effect is poor, and the drug effect is delayed in time; the present invention also provides The preparation method of the oral solution solves the problems in the prior art that the oral solution has low drug efficacy, is prone to produce other side reactions and has low clarity

Method used

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  • Ankahuangmin (Paracetamol, Caffeine, Cow-bezoar and Chlorphenamine Maleate) oral solution and preparation method thereof
  • Ankahuangmin (Paracetamol, Caffeine, Cow-bezoar and Chlorphenamine Maleate) oral solution and preparation method thereof
  • Ankahuangmin (Paracetamol, Caffeine, Cow-bezoar and Chlorphenamine Maleate) oral solution and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] A kind of oral solution of ammoniacal yellow allergy, this oral solution realizes by following steps:

[0064] Step 1, take by weighing 25g paracetamol, 1.5g caffeine, 0.3g chlorpheniramine maleate, 1g artificial bezoar, 2g compound extract, 7.5g ethanol (solubilizer), 1.25g benzoic acid (preservative agent), 0.625g L-cysteine ​​hydrochloride (antioxidant), 0.7g lemon (fragrance), 6.5g glycerin (sweetener), 7g orange flavor (food flavor), 1.5g diatomaceous earth (auxiliary filter);

[0065] Among them, the composite extract is a mixture of 0.5g wolfberry extract, 0.5g ganoderma lucidum extract, 0.2g vitamin C, and 0.8g vitamin B.

[0066] And also include the lansoprazole of 0.1g and sodium bicarbonate coating body particle; Sodium bicarbonate is powder, and coating body is the charcoal powder insoluble in water; The diameter of coating body particle is 5mm; Two layers of coating body (outer layer) is beeswax.

[0067] The preparation method of sodium bicarbonate coa...

Embodiment 2

[0084] A kind of oral solution of ammoniacal yellow allergy, this oral solution realizes by following steps:

[0085] Step 1, take by weighing 20g paracetamol, 1g caffeine, 0.5g chlorpheniramine maleate, 0.5g artificial bezoar, 3g compound extract, 1g ethanol (solubilizer), 0.2g benzoic acid (preservative ), 0.3g L-cysteine ​​hydrochloride (antioxidant), 1.2g lemon (fragrance), 8g glycerin (sweetener), 3g orange flavor (food flavor), 1g diatomaceous earth (filter aid );

[0086] Wherein, the composite extract is a mixture of 0.8g wolfberry extract, 1.2g ganoderma lucidum extract, 0.6g vitamin C, and 0.4g vitamin B.

[0087] And also includes 0.5 g of lansoprazole and sodium bicarbonate coated granules. Sodium bicarbonate is powder, and the coating is charcoal powder insoluble in water. The coating particles had a diameter of 1 mm. The second layer of coating (outer layer) is beeswax. The preparation method of sodium bicarbonate coating body particle is:

[0088] Crush po...

Embodiment 3

[0106] A kind of oral solution of ammoniacal yellow allergy, this oral solution realizes by following steps:

[0107] Step 1, take by weighing 30g paracetamol, 1g caffeine, 0.1g chlorpheniramine maleate, 1.5g artificial bezoar, 0.4g composite extract, 18g ethanol (solubilizer), 1.5g benzoic acid (preservative agent), 0.45g L-cysteine ​​hydrochloride (antioxidant), 0.9g lemon (fragrance), 5g glycerin (sweetener), 10g orange essence (food flavor), 2g diatomaceous earth (filter aid ;

[0108] Wherein, the composite extract is a mixed solution of 0.1 g wolfberry extract, 0.1 g ganoderma lucidum extract, 0.1 g vitamin C, and 0.1 g vitamin B.

[0109] And also includes 1 g of lansoprazole and sodium bicarbonate coated granules. Sodium bicarbonate is powder, and the coating is charcoal powder insoluble in water. The coating particles had a diameter of 0.1 mm. The second layer of coating (outer layer) is propolis. The preparation method of sodium bicarbonate coating body particle...

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Abstract

The invention discloses an Ankahuangmin (Paracetamol, Caffeine, Cow-bezoar and Chlorphenamine Maleate) oral solution which is prepared from the following component per 1L: 20-30g of paracetamol, 1-2gof caffeine, 0.1-0.5g of chlorphenamine maleate, 0.5-1.5g of artificial calculus bovis, 0.4-3g of composite extracting solution, 1-18g of solubilizer, 0-23g of auxiliary material and the balance of purified water. The invention also discloses a preparation method of the Ankahuangmin oral solution. For the Ankahuangmin oral solution and the preparation method provided by the invention, by adding the composite extracting solution formed by a fructus lycii extracting solution, a lucid ganoderma extracting solution, vitamin C and vitamin B, the activity of glutamic-pyruvic transaminase in serum iseffectively lowered, the content of glutathione in liver homogenate is also increased at the same time, and the responding time of the efficacy is effectively shortened; by performing impregnating, dissolving or effective component extraction with Soxhlet extraction on the artificial calculus bovis, an aromatic agent, fructus lycii and lucid ganoderma by using ethanol firstly, influence on structure of each effective component is hard to avoid, and thus the efficacy of a drug in the use process is improved.

Description

technical field [0001] The invention relates to an oral solution of acetaminophen and a preparation method thereof. Background technique [0002] Preparations composed of acetaminophen, caffeine, chlorpheniramine maleate, and artificial bezoar are generally oral solid preparations such as tablets and capsules. The time of onset of effect, the formation of local high drug concentration in the esophageal wall, causing damage such as ulcers and perforation, and inconvenient administration for patients with dysphagia. [0003] In addition, at present, in the process of preparing pharmaceutical oral liquids, the required ingredients of the medicine are directly soaked, boiled, distilled and filtered with purified water, and then in the process of mixing and constant volume, but due to the high boiling point of purified water , In the process of soaking and boiling to extract the active ingredients of the medicine, it will inevitably affect its structure, so that the efficacy of ...

Claims

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Application Information

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Patent Type & AuthorityApplications(China)
IPC IPC(8): A61K36/815A61K9/08A61K47/36A61P11/00A61K36/074A61K31/375A61K31/167A61K31/522A61K31/4402A61K35/413A61K35/644A61K31/4439A61K33/00
CPCA61K9/0095A61K31/167A61K31/375A61K31/4402A61K31/4439A61K31/522A61K33/00A61K35/413A61K35/644A61K36/074A61K36/815A61K47/36A61K2300/00
Inventor刘均正谭闽怀童猛辉
OwnerJIANGXI HEYING PHARMA CO LTD