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Tumor targeted therapy sustained release preparation and preparation method thereof

A technology of tumor-targeting and sustained-release preparations, which is applied in the nanometer field, can solve the problems of unfavorable biological applications, lack of performance, etc., and achieve excellent hydrophilicity and dispersibility, and excellent drug loading efficiency, the effect of enriching surface groups

Inactive Publication Date: 2018-07-13
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This makes the material less valuable as a drug carrier
In addition, the performance of this article in terms of drug release is lacking. The drug release formed by electrostatic adsorption does not have the performance of controlled release and responsive release, which is not conducive to further biological applications.

Method used

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  • Tumor targeted therapy sustained release preparation and preparation method thereof
  • Tumor targeted therapy sustained release preparation and preparation method thereof
  • Tumor targeted therapy sustained release preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] Example 1 Ti 3 AlC 2 Synthesis of MXenes

[0062] Titanium powder (99.5% (w / w) purity, -325 mesh), aluminum powder (99.5% (w / w) purity, -325 mesh) and graphite powder (99.0% (w / w) purity, particle size smaller than 48μm, -300 mesh) was mixed at a molar ratio of 2:1:1, and then ball milled for 10 hours, then pressed into a round cake under a pressure of 30MPa, and then the round cake was placed in a furnace under the condition of argon gas Next, fired at 1500℃ for 2 hours to obtain Ti 3 AlC 2 Ceramic material.

[0063] Will get Ti 3 AlC 2 After the ceramic material is ground, 10g of powder is collected and placed in 60ml of a 40% concentration of hydrofluoric acid aqueous solution. The etching reaction is carried out at room temperature for 3 days, then collected by centrifugation and washed with water and ethanol, and then dispersed in 50ml Stir in a 25% (w / w) TPAOH (Tetrapropylammonium hydroxide) aqueous solution at room temperature for 3 days; then centrifuge and wash wit...

Embodiment 2

[0065] Example 2 Synthesis of MXene nanosheets coated with mesoporous silica

[0066] Premix 10g of 10% (w / w) CTAC (Cetanecyltrimethylammonium chloride) aqueous solution and 0.2g of 10% (w / w) TEA (triethanolamine) aqueous solution at room temperature for 10 minutes, then add 10ml of concentration dropwise Ti obtained in Example 1 at 0.5 mg / ml 3 AlC 2 The aqueous solution of MXenes was stirred at room temperature for 1.5 hours; after that, 150 μl of TEOS was added and stirred at 80°C for 1 hour; then the precipitate was collected by centrifugation and washed with ethanol 3 times. In the above reaction process, CTAC acts as a mesoporous structure guide agent, which can be achieved by using a mixed solvent of ethanol and 37% hydrochloric acid (V Ethanol :V 37% hydrochloric acid =10:1) Wash out at 78°C for 3 times for 12 hours. After that, after washing with ethanol 3 times and washing with deionized water 2 times, the resultant was dispersed in ethanol. Take in-situ bright-field...

Embodiment 3

[0070] On the basis of the scheme of embodiment 2, this embodiment also examines different Ti 3 C 2 The weight ratio of MXenes, CTAC and TEA and TEOS and Ti 3 C 2 The effect of the volume ratio of MXenes material aqueous solution on the microstructure of the obtained material, the results are as follows image 3 Shown.

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Abstract

The invention provides a preparation method of a tumor targeted therapy sustained release preparation. The preparation method comprises the following steps: (1) mixing titanium powder, aluminum powderand graphite powder, ball-milling and pressing, and performing high-temperature sintering under the condition of importing argon gas, thereby obtaining a Ti3AlC2 ceramic material; (2) crushing the material obtained in the step (1) into powder, placing in hydrofluoric acid to react, centrifugally washing, placing in a tetrapropylammonium hydroxide aqueous solution to react, and centrifugally washing to obtain a Ti3C2MXenes material; (3) dropping an aqueous solution of the Ti3C2MXenes material in a mixed aqueous solution of CTAC and TEA to react; and then adding TEOS, reacting under 80 DEG C, and centrifugally washing to obtain an MXene nano-sheet covered by mesoporous silica; and (4), performing polyethylene glycol surface modification on a material obtained in the step (3), covalently combining by using RGD polypeptide, and loading a medicine to obtain the preparation. The tumor targeted therapy sustained release preparation provided by the invention can realize the targeted therapy on tumor and acquire a good tumor-inhibiting effect.

Description

Technical field [0001] The present invention belongs to the field of nanotechnology and drug sustained-release medicament technology, and specifically relates to a tumor-targeted therapy sustained-release preparation and a preparation method thereof. Background technique [0002] In recent years, layered two-dimensional materials have received extensive and in-depth research due to their unique properties, among which graphene nanosheets and black phosphorous nanosheets are mostly studied. MXene is a new type of transition metal carbide or nitride material with a two-dimensional layered structure developed by Yury Gogotsi and Michel W. Barsoum of Drexel University in 2011. It has many properties similar to graphene. , Such as good conductivity, large specific surface area and high strength. At present, about 70 kinds of MXene materials have been discovered, including Ti 3 C 2 , Ti 2 C, V 2 C, Nb 2 C, Nb 4 C 3 , Ta 4 C 3 And Ti 4 N 3 Wait. Over the years, those skilled in the ar...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K47/02A61K47/04A61K47/10A61K47/18A61K31/704A61K31/337A61K33/24A61P35/00
CPCA61K31/337A61K31/704A61K33/24A61K41/0052A61K47/02A61K47/10A61K47/183
Inventor 陈雨李镇利韩骏邢昊王明达杨田
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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