A sustained-release preparation for tumor targeting therapy and its preparation method

A tumor-targeting, sustained-release preparation technology, applied in the nanometer field, can solve the problems of value discount, uncontrollable release and responsive release, unfavorable biological applications, etc., to achieve improved ablation effect, stable drug loading with high drug loading rate , the effect of excellent drug loading rate

Inactive Publication Date: 2021-09-17
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, this material can only realize the drug loading of cationic drugs
This makes the material less valuable as a drug carrier
In addition, the performance of this article in terms of drug release is lacking. The drug release formed by electrostatic adsorption does not have the performance of controlled release and responsive release, which is not conducive to further biological applications.

Method used

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  • A sustained-release preparation for tumor targeting therapy and its preparation method
  • A sustained-release preparation for tumor targeting therapy and its preparation method
  • A sustained-release preparation for tumor targeting therapy and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] Example 1 Ti 3 AlC 2 Synthesis of MXenes

[0062] Titanium powder (99.5% (w / w) purity, -325 mesh), aluminum powder (99.5% (w / w) purity, -325 mesh) and graphite powder (99.0% (w / w) purity, particle size less than 48μm, -300 mesh) in a molar ratio of 2:1:1, and then ball milled for 10h, pressed into a round cake under a pressure of 30MPa, and then put the round cake in the furnace under the condition of feeding argon , fired at 1500°C for 2 hours to obtain Ti 3 AlC 2 Ceramic material.

[0063] Ti 3 AlC 2 After the ceramic material is ground, collect 10g of powder and place it in 60ml of 40% hydrofluoric acid aqueous solution, carry out etching reaction at room temperature for 3 days, then collect by centrifugation and wash with water and ethanol, and then disperse in 50ml Concentration of 25% (w / w) TPAOH (Tetrapropylammonium hydroxide, tetrapropylammonium hydroxide) aqueous solution was stirred at room temperature for 3 days; then centrifuged and washed with water ...

Embodiment 2

[0065] Example 2 Synthesis of MXene nanosheets wrapped in mesoporous silica

[0066] 10g of 10% (w / w) CTAC (Cetanecyltrimethylammonium chloride) aqueous solution and 0.2g of 10% (w / w) TEA (triethanolamine) aqueous solution were pre-mixed and stirred at room temperature for 10 minutes, and then 10ml of concentration was added dropwise. The Ti obtained in embodiment 1 of 0.5mg / ml 3 AlC 2 The aqueous solution of MXenes was stirred at room temperature for 1.5 hours; then, 150 μl of TEOS was added and stirred at 80° C. for 1 hour; then the precipitate was collected by centrifugation and washed 3 times with ethanol. In the above-mentioned reaction process, CTAC can be used as a mesoporous structure guiding agent by utilizing ethanol and 37% hydrochloric acid mixed solvent (V 乙醇 :V 37％盐酸 =10:1) Washed three times for 12 hours at 78°C. Thereafter, after washing 3 times with ethanol and 2 times with deionized water, the resultant was dispersed in ethanol. Carry out in-situ bright ...

Embodiment 3

[0070] On the basis of the scheme of embodiment 2, this embodiment also investigated different Ti 3 C 2 Weight ratio of MXenes, CTAC and TEA and TEOS to Ti 3 C 2 The effect of volume ratio of MXenes material aqueous solution on the microstructure of the obtained material, the results are as follows image 3 shown.

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Abstract

The invention provides a method for preparing a slow-release preparation for tumor targeting therapy, which includes the steps of: (1) mixing titanium powder, aluminum powder and graphite powder for ball milling and pressing, and carrying out high temperature under the condition of feeding argon gas Sintered to get Ti 3 AlC 2 ceramic material; (2) crushing the product of step (1) into powder, reacting in hydrofluoric acid, centrifuging and washing, reacting in tetrapropylammonium hydroxide aqueous solution, centrifuging and washing to obtain Ti 3 C 2 MXenes material; (3) Ti 3 C 2 The aqueous solution of MXenes material is dropped into the mixed aqueous solution of CTAC and TEA to react; then add TEOS, react at 80°C, centrifuge and wash to obtain MXene nanosheets wrapped in mesoporous silica; (4) Polymerize the material in step (3) The surface is modified with ethylene glycol, and then covalently bound with RGD polypeptide to load the drug. The invention can realize the targeted treatment of tumors and obtain good tumor-suppressing effects.

Description

technical field [0001] The invention belongs to the field of nanotechnology and the technical field of drug sustained-release medicaments, and in particular relates to a sustained-release preparation for tumor targeting therapy and a preparation method thereof. Background technique [0002] In recent years, layered two-dimensional materials have been widely and deeply studied due to their unique properties, among which graphene nanosheets and black phosphorus nanosheets are the most studied. MXene is a new type of transition metal carbide or nitride material with a two-dimensional layered structure developed by Yury Gogotsi and Michel W.Barsoum of Drexel University in 2011, which has many properties similar to graphene , such as good electrical conductivity, larger specific surface area and higher strength. At present, about 70 kinds of MXene materials have been discovered, including Ti 3 C 2 、 Ti 2 C, V 2 C. Nb 2 C. Nb 4 C 3 、 Ta 4 C 3 and Ti 4 N 3 Wait. Over t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K41/00A61K47/02A61K47/04A61K47/10A61K47/18A61K31/704A61K31/337A61K33/24A61P35/00
CPCA61K31/337A61K31/704A61K33/24A61K41/0052A61K47/02A61K47/10A61K47/183
Inventor 陈雨李镇利韩骏邢昊王明达杨田
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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