Novel cranial base repair material and preparation method and application thereof

Abstract

The invention discloses a novel cranial base repair material, comprising two biofilm layers and a support. The support is horizontally arranged between the two biofilm layers. The biofilm is of animalmembrane material, selected from at least one of animal pericardium, peritoneum and omentum majus; the support is a shape memory alloy support, a polymer material support or a ceramic material support. In addition, the invention also provides a preparation method and application of the novel cranial base repair material. The novel cranial base repair material has good biocompatibility, can comprise animal membrane material inducing body tissue repair and the support applicable to human transplanting, has the advantages of good manufacture simplicity, wide range of sources, good convenience ofuse, capability to induce tissue reconstruction and regeneration and the like, can prevent cerebrospinal fluid leakage, soft tissue prolapse and the like, and can provide both mechanical support andtissue regeneration induction.

Description

technical field [0001] The invention belongs to the technical field of medical biomaterials, and in particular relates to a novel skull base repair material and its preparation method and application. Background technique [0002] When the autologous tissue of the skull base is unavoidably injured due to surgery, the area of ​​the injury is generally small, and the position is not closely related to other tissues, which is less harmful to the patient and does not require special treatment. However, most autologous tissue injuries of the skull base, especially those caused by diseased tissues, can easily cause leakage of intracranial cerebrospinal fluid, swelling of the contents, and collapse of the skull if no special treatment is performed. In order to avoid such side effects, the skull base tissue Repair of skull base defect tissue is best performed after lesion removal or postoperatively. Traditional skull base tissue repair generally uses materials such as autologous bo...

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Problems solved by technology

[0003] Among the existing skull base repair materials, although autologous bone, cartilage, autologous adipose tissue and other materials have no risk of immune reaction, the raw materials are limited, and will cause secondary trauma, which will bring bad medical experience to patients. Use less; gelatin sponge, collagen sponge and other heterogeneous materials have poor mechanical support and cannot provide the necessary supporting functions. At the same time, they degrade quickly in the body and cannot provide the necessary mechanical support for a long time. Viruses

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