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Enteric sustained release oxytetracycline calcium premix and preparation method thereof

A technology of oxytetracycline calcium and premix, which is applied in the direction of active ingredients of tetracycline, microcapsules, non-active ingredients of oil/fat/wax, etc., can solve the problems of low bioavailability of oxytetracycline, and improve palatability, Effects of inhibiting reproduction and increasing mobility

Pending Publication Date: 2018-07-27
青岛润博特生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The present invention proposes an enteric-coated slow-release oxytetracycline calcium premix and its preparation method, which solves the problem of low bioavailability of oxytetracycline in animals in the prior art

Method used

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  • Enteric sustained release oxytetracycline calcium premix and preparation method thereof
  • Enteric sustained release oxytetracycline calcium premix and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Such as figure 1 Shown, a kind of preparation method of enteric-coated slow-release oxytetracycline calcium premix comprises steps:

[0025] 1) Take by weight the ball core raw material, 5kg oxytetracycline, 10kg hydroxypropyl methylcellulose, 10kg chitosan and 40kg calcium carbonate, mix and stir evenly after pulverizing 80 mesh sieves respectively, add 10kg water , made of soft material,

[0026] 2) Add the soft material into a screw extruder, use a sieve plate with an aperture of 0.3mm, extrude the strips, transfer the obtained strips into a spheronizer, control the spheronization rate to 1000rpm, and roll them into pellets. The pellets were dried at 60°C, the water content was controlled within 8%, and after drying, they passed through a vibrating sieve with a screen mesh of 30 mesh to obtain oxytetracycline calcium pills;

[0027] 3) take the enteric coating layer by weight percentage, get 10kg carnauba wax, 20kg palm oil ester, be all dissolved in the 15kg polye...

Embodiment 2

[0029] Such as figure 1 Shown, a kind of preparation method of enteric-coated slow-release oxytetracycline calcium premix comprises steps:

[0030] 1) Take by weight percentage 10kg oxytetracycline, 10kg hydroxypropyl methylcellulose, 15kg chitosan and 25kg calcium carbonate, pulverize respectively and mix and stir evenly after crossing 80 mesh sieves, and then add 25 kg of ball core. % of water, made of soft materials,

[0031] 2) Add the soft material into a screw extruder, use a sieve plate with an aperture of 0.3mm, extrude the strips, transfer the obtained strips into a spheronizer, control the spheronization rate to 1000rpm, and roll them into pellets. The pellets are dried at 65° C., the water content is controlled within 8%, and after drying, they are passed through a vibrating sieve with a screen mesh of 30-50 mesh to obtain oxytetracycline calcium pellets;

[0032] 3) take the enteric coating layer by weight percentage, get 15kg carnauba wax, 20kg palm oil ester, b...

Embodiment 3

[0034] Such as figure 1 Shown, a kind of preparation method of enteric-coated slow-release oxytetracycline calcium premix comprises steps:

[0035] 1) Take by weight percentage 20kg oxytetracycline, 15kg hydroxypropyl methylcellulose, 15kg chitosan and 10kg calcium carbonate, pulverize respectively and mix and stir evenly after crossing 80 mesh sieves, then add ball core weight 20kg -30% water, made into soft materials,

[0036] 2) Add the soft material into a screw extruder, use a sieve plate with an aperture of 0.3mm, extrude the strips, transfer the obtained strips into a spheronizer, control the spheronization rate to 1000rpm, and roll them into pellets. The pellets are dried at 70° C., the water content is controlled within 8%, and after drying, they pass through a vibrating sieve with a sieve of 50 mesh to obtain oxytetracycline calcium pellets;

[0037]3) take the enteric coating layer by weight percentage, get 15kg carnauba wax, 20kg palm oil ester, be all dissolved ...

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Abstract

The invention discloses an enteric sustained release oxytetracycline calcium premix and a preparation method thereof. The enteric sustained release oxytetracycline calcium premix solves the problem oflow utilization ratio of oxytetracycline in animals in the prior art. The enteric sustained release oxytetracycline calcium premix is composed of a pill core and an enteric coating layer, wherein thepill core is composed of raw materials including, by weight percentage, 8-40% of oxytetracycline, 1-20% of adhesives, 10-30% of pore-forming agent and 15-40% of lubricating agent; the enteric coatinglayer is composed of raw materials including, by weight percentage, 20-50% of carnauba wax, 10-30% of palm oil and 15-30% of organic solvent. The enteric sustained release oxytetracycline calcium premix can protect oxytetracycline from dissolution and absorption in stomach and ensure rapid decomposition of enteric substance inside intestines to release oxytetracycline to further regulate intestinal microflora, improve the intestinal state, increase the utilization rate of nutrients and accordingly achieve the functions of growth promotion and health care.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to an enteric-coated slow-release oxytetracycline calcium premix and a preparation method thereof. Background technique [0002] Oxytetracycline is an antibiotic developed by the United States in 1949. It is the most produced and used antibiotic in our country. Oxytetracycline is off-white or golden yellow crystalline powder. It is usually produced and used as oxytetracycline sodium or calcium salt, which can improve the stability of oxytetracycline. It has a wide range of antibacterial properties against Gram-positive bacteria, negative bacteria, Leptospira, Rickettsia and large viruses, and is an effective drug for respiratory diseases and dysentery in chickens, pigs and calves. The most important feature of the antibacterial activity of oxytetracycline is the inclusion of a linearly fused tetracycline core in the drug molecule. The simplest tetracycline molecule with antiba...

Claims

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Application Information

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IPC IPC(8): A61K9/50A61K31/65A61K47/44A61P31/04
CPCA61K31/65A61K9/5015
Inventor 张小东王清新秦伟陈强任洋洋
Owner 青岛润博特生物科技有限公司
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