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Method for preparing self-repairing hydrogel by guiding polymerization through natural polymer template

A natural polymer and self-healing technology, applied in the field of self-healing polymer hydrogel, can solve the problems of poor recoverability and self-healing ability, poor toughness, low mechanical strength, etc., to improve the interaction and increase the binding position point, self-healing process simple effect

Inactive Publication Date: 2018-07-31
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most self-healing hydrogels suffer from many defects, such as low mechanical strength, poor toughness, poor recoverability and self-healing ability, etc.

Method used

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  • Method for preparing self-repairing hydrogel by guiding polymerization through natural polymer template

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] 1) Dissolve 1g of sodium alginate in 100mL of deionized water; dissolve 0.2g of sodium periodate in 20mL of deionized water, and add dropwise to the sodium alginate solution, and stir for 12 hours at room temperature; then add 0.1 mL ethylene glycol, continue to stir for 0.5 hours; then add the above mixed solution dropwise to 0.2L ethanol solution to precipitate, filter and vacuum dry for 2 hours, seal and refrigerate for later use.

[0026] 2) Dissolve 0.1 g of oxidized sodium alginate in 6.5 mL of deionized water, then add 0.5 g of acrylic acid monomer and stir for 20 min.

[0027] 3) Add 0.5mL NaOH (0.5mol / L) solution to the above mixture, and continue stirring for 20min.

[0028] 4) Add 0.0025 g of ammonium persulfate to the above solution, and continue stirring for 10 min.

[0029] 5) Add 0.0025 mL of tetramethylethylenediamine to the above solution, and continue stirring for 1 min.

[0030] 6) Inject the above liquid into a specific mold and react at 25°C for 1...

Embodiment 2

[0034] 1) Dissolve 5g of sodium alginate in 100mL of deionized water; dissolve 10g of sodium periodate in 20mL of deionized water, and add dropwise into the sodium alginate solution, and stir for 12 hours at room temperature; then add 5mL of ethyl alcohol dropwise Diol, continue to stir for 0.5 hours; then add the above mixed solution dropwise to 1.0L ethanol solution to precipitate, filter and vacuum dry for 12 hours, seal and refrigerate for later use.

[0035] 2) Dissolve 0.1 g of oxidized sodium alginate in 6.5 mL of deionized water, then add 0.5 g of acrylic acid monomer and stir for 20 min.

[0036] 3) Add 0.5mL NaOH (0.5mol / L) solution to the above mixture, and continue stirring for 20min.

[0037] 4) Add 0.0025 g of ammonium persulfate to the above solution, and continue stirring for 10 min.

[0038] 5) Add 0.0025 mL of tetramethylethylenediamine to the above solution, and continue stirring for 1 min.

[0039] 6) Inject the above liquid into a specific mold and react...

Embodiment 3

[0043] 1) Dissolve 2.5g sodium alginate in 100mL deionized water; dissolve 2.5g sodium periodate in 20mL deionized water, and add dropwise to the sodium alginate solution, stir for 12 hours at room temperature; then add dropwise 2mL ethylene glycol, continue to stir for 0.5 hours; then add the above mixed solution dropwise to 0.5L ethanol solution to precipitate, filter and vacuum dry for 12h, seal and refrigerate for later use.

[0044] 2) Dissolve 0.1 g of oxidized sodium alginate in 6.5 mL of deionized water, then add 0.5 g of acrylic acid monomer and stir for 20 min.

[0045] 3) Add 0.5mL NaOH (0.5mol / L) solution to the above mixture, and continue stirring for 20min.

[0046] 4) Add 0.0025 g of ammonium persulfate to the above solution, and continue stirring for 10 min.

[0047] 5) Add 0.0025 mL of tetramethylethylenediamine to the above solution, and continue stirring for 1 min.

[0048] 6) Inject the above liquid into a specific mold and react at 25°C for 1 hour.

[0...

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PUM

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Abstract

The invention discloses a method for preparing self-repairing hydrogel by guiding polymerization through a natural polymer template. The method comprises the following steps: taking a linear-chain natural polymer containing aldehyde groups as a template, fixing monomeric molecules containing amino groups on the natural polymer template through the action of Schiff base under alkaline conditions, and then, performing free radical polymerization to prepare polymer hydrogel with high rebound resilience and self-repairing performance. By virtue of existence of the natural linear-chain polymer template in the method disclosed by the invention, polymerization of monomers can be effectively guided, and dynamic chemical cross-linking sites are increased, thereby improving the mechanical strength and the self-repairing capability of the hydrogel. The hydrogel prepared by the method disclosed by the invention has broad application prospects in the related fields of artificial tissues and biomedicine.

Description

technical field [0001] The invention belongs to the field of self-repairing polymer hydrogel, and relates to a method for preparing a natural polymer-polyacrylamide composite hydrogel. Background technique [0002] In recent years, biomimetic self-healing materials have attracted extensive attention, especially the design and application of self-healing polymer hydrogels. As a kind of soft material with high water content, polymer self-healing hydrogel can possess many excellent properties besides self-healing after damage, such as biocompatibility, adsorption, anti-biofouling behavior and biodegradability. . Based on these properties, polymer self-healing hydrogels have been initially applied in the fields of tissue engineering, drug carriers, and biosensors. However, most self-healing hydrogels suffer from many defects, such as low mechanical strength, poor toughness, poor recoverability and self-healing ability, etc. Scientists have done a lot of work on high-strength ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F251/00C08F251/02C08F220/06
CPCC08F251/00C08F251/02C08F220/06
Inventor 付国东刘顺利姚芳
Owner SOUTHEAST UNIV
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