Magnesium alloy biliary stent and preparation method thereof

A magnesium alloy stent and magnesium alloy technology are applied in the field of medical devices to achieve the effect of reducing the occurrence probability of bile leakage, excellent biocompatibility and reducing inflammatory response

Inactive Publication Date: 2018-08-03
秦高平
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  • Abstract
  • Description
  • Claims
  • Application Information

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  • Magnesium alloy biliary stent and preparation method thereof
  • Magnesium alloy biliary stent and preparation method thereof
  • Magnesium alloy biliary stent and preparation method thereof

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[0040] The invention discloses a preparation method of a magnesium alloy biliary stent, which comprises the following steps:

[0041] Step 1, preparing small intestinal submucosa (SIS, smallintestinalsubmucosa) matrix;

[0042] Step 1.1. Pretreatment: Take the fresh pig jejunum slaughtered within 4 hours, wash it repeatedly with water and put it in an ice pack for later use. Select the part with uniform lumen thickness, no damage to the tube wall and no lymph node attachment, and cut it into 10-12cm in length For the small segment, first use a scalpel to separate the edge of the mucosal layer, then use a vascular forceps wrapped in gauze to remove the serosa layer and muscular layer by frustrating, and wash it with 35-38°C water

[0043] Step 1.2, ultrasonic combined with chemical method processing:

[0044] Place the small intestinal submucosa treated in step 1.1 in 0.5% SDS physiological saline solution for 1.5-2h and sonicate at 35-38°C, then wash with 1mmol / L NaCl solutio...

Embodiment 1

[0059] A preparation method of a magnesium alloy biliary stent, comprising the following steps:

[0060] Step 1, preparing small intestinal submucosa (SIS, smallintestinalsubmucosa) matrix;

[0061] Step 1.1. Pretreatment: Take fresh porcine jejunum slaughtered within 4 hours, rinse it repeatedly with water and put it in an ice pack for later use. Select the part with uniform lumen thickness, no damage to the tube wall, and no lymph node attachment, and cut it into small pieces with a length of 11 cm. First, use a scalpel to separate the edge of the mucosal layer, then use a vascular forceps wrapped in gauze to remove the serosa layer and muscular layer by frustrating, and wash it with 37°C water

[0062] Step 1.2, ultrasonic combined with chemical method processing:

[0063] Place the small intestinal submucosa treated in step 1.1 in 0.5% SDS physiological saline solution for 1.8 hours and sonicate at 37°C, then wash with 1 mmol / L NaCl solution 4 times;

[0064]Step 1.3. So...

Embodiment 2

[0077] A preparation method of a magnesium alloy biliary stent, comprising the following steps:

[0078] Step 1, preparing small intestinal submucosa (SIS, smallintestinalsubmucosa) matrix;

[0079] Step 1.1. Pretreatment: Take the fresh pig jejunum slaughtered within 4 hours, rinse it repeatedly with water and put it in an ice pack for later use. Select the part with uniform lumen thickness, no damage to the tube wall, and no lymph node attachment, and cut it into small pieces with a length of 10 cm. First, use a scalpel to separate the edge of the mucosal layer, then use a vascular forceps wrapped in gauze to remove the serosa layer and muscular layer by grinding, and wash it with 38°C water

[0080] Step 1.2, ultrasonic combined with chemical method processing:

[0081] The small intestinal submucosa treated in step 1.1 was placed in 0.5% SDS saline solution for 1.5 h, and the ultrasonic temperature was 38°C, and then washed 3 times with 1 mmol / L NaCl solution;

[0082] S...

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Abstract

The invention discloses a magnesium alloy biliary stent and a preparation method thereof. The magnesium alloy biliary stent comprises an extensible magnesium alloy stent body, wherein small intestinemucous membrane lower-layer matrix layers are arranged on the inner wall and the outer wall of the magnesium alloy stent body. The preparation method comprises the following steps that the small intestine mucous membrane lower-layer matrix layers are prepared; the magnesium alloy stent body is pretreated to remove oxide on the surface of the stent body; electrolyte is prepared, wherein the magnesium alloy stent body is put in micro-arc oxidized electrolyte, the magnesium alloy stent body serves as an anode, and a stainless-steel electrolytic tank serves as a cathode to perform micro-arc oxidization treatment; a test sample is post-treated; the prepared small intestine mucous membrane lower-layer matrix layers are suture or bonded on the inner layer and the outer layer of the magnesium alloy stent body respectively to obtain the magnesium alloy biliary stent. The magnesium alloy biliary stent has good biocompatibility, can be biodegraded into a nontoxic product and has no immunogenicity.

Description

technical field [0001] The invention belongs to the technical field of medical devices, and in particular relates to a magnesium alloy biliary stent and a preparation method thereof. Background technique [0002] Since the late 1980s, the metal internal stent was successfully developed. Because of its simple operation, less trauma and satisfactory effect, it has been widely used clinically, especially in the liver and gallbladder. Combined with percutaneous transhepatic biliary drainage (PTCD) and twelve Denoscopy and other techniques for the treatment of biliary stricture, primary suture of biliary tract, bile leakage, and even liver transplantation have been accepted by clinicians. However, at present, the main materials of metal stents in the biliary tract are stainless steel, nickel-titanium alloy, platinum-iridium alloy, cobalt-chromium alloy, tantalum, titanium, etc., which are all non-absorbable materials, and all of them have certain toxic and side effects on the who...

Claims

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Application Information

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IPC IPC(8): A61F2/82C25D11/02C25D11/30
CPCA61F2/82A61F2/0077A61F2210/0004A61F2240/001A61F2310/00041C25D11/026C25D11/30
Inventor 秦高平宋勇
Owner 秦高平
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