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A kind of mixed photonic crystal and its preparation method and application

A technology of photonic crystals and magnetic nanoparticles, applied in optics, optical components, instruments, etc., can solve the problems of large damage to CTCs and limited capture efficiency of CTCs, and achieve the effects of high mechanical strength, superior magnetic responsiveness, and easy manipulation

Active Publication Date: 2019-08-20
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, nanomaterials are used as carriers, and it is difficult to maintain a stable structure while having good biocompatibility. Therefore, the capture efficiency of CTCs based on these carriers is limited and the damage to CTCs is relatively large.

Method used

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  • A kind of mixed photonic crystal and its preparation method and application
  • A kind of mixed photonic crystal and its preparation method and application
  • A kind of mixed photonic crystal and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Preparation of silica colloidal microspheres (SCCBs):

[0039] (1) SiO 2 After the nanoparticles were sonicated for 1 h, they were centrifuged at 8000 rpm for 10 min, and ultrapure water was added after removing the supernatant, and the above steps were repeated 20 times.

[0040] (2) SiO after the above cleaning 2 The nanoparticles were formulated into an emulsion with a mass fraction of 20%, and ultrasonicated for 30 minutes.

[0041] (3) Add an appropriate amount of n-hexadecane (containing 1% Hypermer2296 surfactant) to the collector and the oil phase injector, preheat at 45°C, adjust the oil phase speed to 2ml / h and the water phase speed to 1ml / h; wherein, Liquid volume of n-hexadecane: the distance from the bottom of the collector is about 0.3cm. If the amount is large, the balls will easily float and merge with each other. If the amount is small, the balls will not be in a suspended state and cause collapse; The amount of alkane is more than three times the to...

Embodiment 2

[0064]Preparation of silica colloidal microspheres (SCCBs):

[0065] Step is identical with embodiment 1.

[0066] Preparation of hybrid photonic crystals:

[0067] (1) Preparation of pregel A: polyethylene glycol diacrylate 70%, photoinitiator 2% and water 28%; preparation of pregel B: methacrylate gelatin (GelMA), iron concentration is 4mg / ml Magnetic nano particle suspension, photoinitiator and water, wherein, the volume ratio of magnetic nano particle suspension, water and photoinitiator is 2:60:1, and magnetic nano particle is carboxylated ferroferric oxide magnetic nano particle.

[0068] (2) Preparation of inverse opal framework of polyethylene glycol diacrylate (PEGDA): Wrap the transparent plastic centrifuge tube containing SCCBs with tinfoil, add pre-gel A dropwise until it is completely covered, shake properly, and let stand at room temperature 45min, so that the pregel A is fully immersed in the pores of SCCBs; then use ultraviolet light to polymerize for 20s. P...

Embodiment 3

[0071] Preparation of silica colloidal microspheres (SCCBs):

[0072] Step is identical with embodiment 1.

[0073] Preparation of hybrid photonic crystals:

[0074] (1) Preparation of pre-gel A: polyethylene glycol diacrylate 90%, photoinitiator 1% and water 9%; preparation of pre-gel B: methacrylate gelatin (GelMA), iron concentration of 4mg / ml Magnetic nano particle suspension, photoinitiator and water, wherein, the volume ratio of magnetic nano particle suspension, water and photoinitiator is 3:80:1.

[0075] (2) Preparation of inverse opal framework of polyethylene glycol diacrylate (PEGDA): Wrap the transparent plastic centrifuge tube containing SCCBs with tinfoil, add pre-gel A dropwise until it is completely covered, shake properly, and let stand at room temperature 30min, so that the pregel A is fully immersed in the pores of SCCBs; then use ultraviolet light to polymerize for 40s, during the polymerization process, the centrifuge tube is turned over at a constant s...

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Abstract

The invention discloses a mixed photonic crystal, and a preparation method and applications thereof. The mixed photonic crystal comprises a polyethylene glycol 200 diacrylate inverse opal skeleton andmetacrylic acid ester gelatin and magnetic nanoparticles used for filling apertures of the skeleton. According to the preparation method, silica colloidal microspheres are taken as a template, a pre-gel A is added for reaction and polymerization, and the silica colloidal microspheres are removed so as to obtain the polyethylene glycol 200 diacrylate inverse opal skeleton; pre-gel B is added intothe polyethylene glycol 200 diacrylate inverse opal skeleton for reaction and polymerization so as to obtain a finished product. The mixed photonic crystal can be used in drug resistance cell detection as a carrier. The mixed photonic crystal is high in stability, possesses excellent biocompatibility and magnetic responsiveness; the preparation method is simple; the operationality is high; the preparation method is friendly to the environment; the mixed photonic crystal can be used in drug resistant cell detection; the surface of the mixed photonic crystal can be loaded with folic acid; and simple and effective capturing of myeloid leukemia drug resistance cells can be realized with high specificity and sensitivity.

Description

technical field [0001] The invention belongs to the field of photonic crystals, in particular to a mixed photonic crystal and its preparation method and application. Background technique [0002] Leukemia is one of the top ten malignant tumors. It is a malignant tumor of the blood system. Although great progress has been made in its diagnosis and treatment, and its five-year survival rate has also been greatly improved, its morbidity and mortality are still It is at a relatively high level, and it is showing an increasing trend in our country, so the prevention and treatment of leukemia is still a major issue facing our public health. The main treatments for leukemia are chemotherapy, targeted drug therapy, stem cell transplantation and immunotherapy. Among them, drug therapy is the cornerstone of leukemia treatment. Chemotherapy is required to induce remission before hematopoietic stem cell transplantation. Targeted drug therapy can greatly improve treatment efficiency a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F120/28C08F120/36C08F2/48C08F2/44C08K3/22C08F8/30G02B1/00
Inventor 陈宝安栾成欣周芳马晓燕张静
Owner SOUTHEAST UNIV
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