Nanomedicine based on lipoyl-terminated star polymers

Abstract

The invention discloses a nano-drug based on a terminal lipoyl-containing star polymer. A side chain lipoyl-containing star polymer is obtained by esterification reaction; LA substitution degree controllability has excellent biocompatibility and can be used for controlling a drug release system; a prepared cancer-targeting reduction sensitive reversible cross-linked polymer nanoparticle nano-drugsupports an in vivo stable long cycle, is enriched in cancer tissues, efficiently enters cells, and quickly decrosslinks in the cells to release the drug; cancer cells are efficiently and specificallykilled, so that toxic or side effects caused by growth of the cancers are effectively inhibited.

Description

technical field

[0001] The invention relates to a biocompatible polymer material and its application, in particular to a nano-medicine based on a star-shaped biocompatible polymer containing a lipoyl group at the end, which belongs to the field of medical materials. Background technique

[0002] Polymer materials with good biocompatibility and biodegradability have been widely used in biomedical fields, including tissue engineering and drug controlled release. The polymer nanomedicine prepared by the technology has the problems of unstable circulation in the body, low tumor cell uptake, low intracellular drug concentration, and slow intracellular drug release rate, resulting in low efficacy of nanomedicine and toxic side effects caused by drug leakage. ; For example, the results of BIND-014 in the second clinical phase did not meet expectations, due to the insufficient stability of the nano drug in vivo.

[0003] Cancer is a major killer that threatens human health, and its...

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