Oral spray preparation and preparation method thereof
An oral spray and preparation technology, which is applied in the field of oral spray preparations and its preparation, can solve the problems of insignificant drug sustained release, low drug utilization, and limited drugs, so as to facilitate the development of drugs and improve bioavailability , little side effects
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Embodiment 1
[0030] This embodiment provides a kind of mouth spray preparation, is prepared by weight ratio by following composition:
[0031]
[0032] The preparation method is as follows:
[0033] (1) Dissolving fatty acid choline, glyceryl dioleate and amikacin under the effect of dehydrated alcohol, after dissolving, volatilize dehydrated alcohol to obtain phosphatidylcholine / glyceride dioleate lipid solution;
[0034] (2) Under stirring conditions, the above-mentioned fatty acylcholine / diolein lipid solution containing amikacin is dropped into ultrapure water, and then continue to stir for a period of time;
[0035] (3) The solution in step (2) was sheared at a high speed of 8000r / min for 2min, then subjected to high-pressure homogenization, the homogenization pressure was 200bar, and the homogenization cycle was performed 3 times to obtain drug-loaded liquid crystal nanoparticles;
[0036] c. Dissolve the calcium alginate in water as component X; dissolve the thiolated calcium al...
Embodiment 2
[0040] This embodiment provides a kind of mouth spray preparation, is prepared by weight ratio by following composition:
[0041]
[0042]
[0043] Prepare the oral spray formulation according to the preparation method of Example 1, and test the prepared oral spray formulation to obtain: the encapsulation efficiency of the drug-loaded liquid crystal nanoparticles is 80%, and the particle size of the drug-loaded liquid crystal nanoparticles is 80-300nm, PDI is less than 0.3, and the film-forming time when sprayed on the affected part of the oral cavity is 7s.
Embodiment 3
[0045] This embodiment provides a kind of mouth spray preparation, is prepared by weight ratio by following composition:
[0046]
[0047] Prepare the oral spray formulation according to the preparation method of Example 1, and test the prepared oral spray formulation to obtain: the encapsulation efficiency of the drug-loaded liquid crystal nanoparticles is 75%, and the particle size of the drug-loaded liquid crystal nanoparticles is 250-400nm, PDI is less than 0.5, and the film-forming time when sprayed on the affected part of the oral cavity is 10s.
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