Eureka AIR delivers breakthrough ideas for toughest innovation challenges, trusted by R&D personnel around the world.

Oral spray preparation and preparation method thereof

An oral spray and preparation technology, which is applied in the field of oral spray preparations and its preparation, can solve the problems of insignificant drug sustained release, low drug utilization, and limited drugs, so as to facilitate the development of drugs and improve bioavailability , little side effects

Active Publication Date: 2018-08-17
武汉百纳礼康生物制药有限公司
View PDF5 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The oral sprays currently on the market can directly act on the affected area, but due to the retention of saliva in the oral cavity, the drugs are diluted and ineffective; some oral sprays are applied to the affected area and can form a film on the affected area to prevent saliva from being taken away Drugs, but the slow-release effect of the drugs is not obvious, and the drugs acting on the affected area are limited, resulting in low utilization of the drugs; in addition, the existing oral sprays need to add a variety of chemical auxiliary agents to make them have a longer shelf life

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Oral spray preparation and preparation method thereof
  • Oral spray preparation and preparation method thereof
  • Oral spray preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] This embodiment provides a kind of mouth spray preparation, is prepared by weight ratio by following composition:

[0031]

[0032] The preparation method is as follows:

[0033] (1) Dissolving fatty acid choline, glyceryl dioleate and amikacin under the effect of dehydrated alcohol, after dissolving, volatilize dehydrated alcohol to obtain phosphatidylcholine / glyceride dioleate lipid solution;

[0034] (2) Under stirring conditions, the above-mentioned fatty acylcholine / diolein lipid solution containing amikacin is dropped into ultrapure water, and then continue to stir for a period of time;

[0035] (3) The solution in step (2) was sheared at a high speed of 8000r / min for 2min, then subjected to high-pressure homogenization, the homogenization pressure was 200bar, and the homogenization cycle was performed 3 times to obtain drug-loaded liquid crystal nanoparticles;

[0036] c. Dissolve the calcium alginate in water as component X; dissolve the thiolated calcium al...

Embodiment 2

[0040] This embodiment provides a kind of mouth spray preparation, is prepared by weight ratio by following composition:

[0041]

[0042]

[0043] Prepare the oral spray formulation according to the preparation method of Example 1, and test the prepared oral spray formulation to obtain: the encapsulation efficiency of the drug-loaded liquid crystal nanoparticles is 80%, and the particle size of the drug-loaded liquid crystal nanoparticles is 80-300nm, PDI is less than 0.3, and the film-forming time when sprayed on the affected part of the oral cavity is 7s.

Embodiment 3

[0045] This embodiment provides a kind of mouth spray preparation, is prepared by weight ratio by following composition:

[0046]

[0047] Prepare the oral spray formulation according to the preparation method of Example 1, and test the prepared oral spray formulation to obtain: the encapsulation efficiency of the drug-loaded liquid crystal nanoparticles is 75%, and the particle size of the drug-loaded liquid crystal nanoparticles is 250-400nm, PDI is less than 0.5, and the film-forming time when sprayed on the affected part of the oral cavity is 10s.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
particle diameteraaaaaaaaaa
particle diameteraaaaaaaaaa
Login to View More

Abstract

The invention discloses a oral spray preparation and a preparation method thereof. The oral spray preparation is prepared from liquid crystal materials, alginate and mercapto polymer. The preparationmethod of the oral spray preparation comprises the following steps: firstly, dissolving and dispersing a medicine and the liquid crystal materials under an effect of a co-solvent so as to form medicine-carrier liquid crystal nanoparticles; then enveloping the medicine-carrier liquid crystal nanoparticles by adopting the alginate, so that the stability of the medicine-carrier liquid crystal nanoparticles can be greatly improved through the operations, a slow release effect is obvious, and deactivation of the medicine and aggregation and precipitation of the nanoparticles are prevented; the mercapto polymer and half-cystine in a body are combined on an affected part to form a film so as to play isolation and protection effects on the affected part, and therefore, the acting time of the medicine is prolonged, the concentration of the local medicines is obviously increased, development of the medicine is facilitated, the condition that a medicament is diluted due to retention of saliva inan oral cavity so as to lose efficacy is avoided.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular to an oral spray preparation and a preparation method thereof. Background technique [0002] The skin tissue in the oral cavity often suffers from various skin injuries, such as ulcers, wounds, burns, etc., which may cause health problems in the body. Studies have shown that skin wound healing is a complex pathophysiological process. During the wound healing process, because the oral cavity is a humid and hot environment, and contains more bacteria, the wound healing process will be prolonged and healing will be difficult. [0003] Chinese patent No. CN105687247A discloses a preparation method of a spray film for the treatment of oral ulcers. Extract cod liver oil and propolis compound homogenate from cod liver to obtain propolis nano-emulsion, supplemented with pearl powder, secretly prepared in an autoclave, and steam sterilized. Thereby the preparation method of the s...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/12A61K9/70A61K9/51A61K31/7036A61K31/65A61K31/155A61K47/32A61K47/36A61K47/38A61P1/02
CPCA61K9/006A61K9/5161A61K9/7015A61K31/155A61K31/65A61K31/7036A61K47/32A61K47/36A61K47/38A61P1/02A61K2300/00
Inventor 罗亮黄丽萍孟凡玲
Owner 武汉百纳礼康生物制药有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Eureka Blog
Learn More
PatSnap group products