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Chinese soapberry fruit ether extract and preparation method, test method and application thereof

A technology of Sapindus japonica and extract, applied in the direction of measuring device, drug combination, pharmaceutical formula, etc., can solve the problem of unsatisfactory effect of natural plant antibacterial ingredients, and achieve the effect of expanding the use of drugs, a wide variety and a wide range of sources.

Inactive Publication Date: 2018-08-17
南京福科帝生物科技有限公司
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Problems solved by technology

[0005] Although it has been reported that Sapindus fruit peel extract can inhibit the growth of Propionibacterium acnes, the existing antibiotics for inhibiting Propionibacterium acnes have limitations, and the antibacterial effects of natural plant ingredients reported in the past are not ideal. The MIC is 40-125 mg / mL, and no component analysis has been performed on the active substance that inhibits Propionibacterium acnes

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  • Chinese soapberry fruit ether extract and preparation method, test method and application thereof
  • Chinese soapberry fruit ether extract and preparation method, test method and application thereof
  • Chinese soapberry fruit ether extract and preparation method, test method and application thereof

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[0032] One aspect of the embodiments of the present invention provides a method for preparing a sapinberry ether extract, which comprises: using ethers as a solvent, performing vibration extraction on the sapinberry peel at 20-40°C to obtain sapinberry ether class extract.

[0033] In some embodiments, the preparation method specifically includes:

[0034] (1) At 20-40°C, soak the Sapindus pericarp with an ether compound, vibrate and extract for 10-16 hours, preferably 12-16 hours, and then filter and recover the residue, wherein the Sapinberry pericarp and the ether compound The mass-volume ratio is 100g: 300-500mL;

[0035] (2) At 20-40°C, the residue is soaked in ether compounds, subjected to vibration extraction for 8-14 hours, preferably 8-12 hours, and the extract is collected by filtration, wherein the Sapindus pericarp and ether compounds The mass volume ratio is 100g:200~400mL;

[0036] (3) Suction filtration and concentration of the extracts obtained in steps (1) ...

Embodiment 1

[0054] The Sapinberry peel ether extract of the present embodiment is prepared by the following method:

[0055] Grind 100g of sapindus pericarp, pass through a 20-mesh sieve to obtain sapinsia pericarp powder, first soak in 300mL of ether, shake and extract at 30°C at 130rpm for 10h, then filter and recover the residue; soak the residue in ether again, Shake and extract at 130rpm at 30°C for 14h, 400mL of diethyl ether is needed for every 100g of residue, and the extract is collected by filtration. Suction filtration and concentration of the two extracts were carried out to obtain the ether extract of Sapindus chinensis.

Embodiment 2

[0057] The Sapinberry peel ether extract of the present embodiment is prepared by the following method:

[0058] Grind 100g of sapindus pericarp, pass through a 40-mesh sieve to obtain sapinsia pericarp powder, first soak in 400mL of ether, shake and extract at 20°C at a speed of 150rpm for 16h, then filter and recover the residue; soak the residue in ether again, Shake and extract at 150rpm at 20°C for 12h, 300mL of diethyl ether is needed for every 100g of residue, and the extract is collected by filtration. Suction filtration and concentration of the two extracts were carried out to obtain the ether extract of Sapindus chinensis.

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Abstract

The invention discloses a Chinese soapberry fruit ether extract and a preparation method, a test method and application thereof. The preparation method for the Chinese soapberry fruit ether extract comprises the following step: with an ether compound as a solvent, Chinese soapberry fruit peels undergo vibrating extraction under 20 DEG C to 40 DEG C, so that the Chinese soapberry fruit ether extract is obtained. The Chinese soapberry fruit ether extract is prepared from organic acid, phenolic acid, flavonol, amino acid, saponin substance and the like, and an in-vitro bacteriostatic experiment indicates that the MIC (minimal inhibitory concentration) of the Chinese soapberry fruit ether extract on propionibacterium acnes is 0.125mg / mL. The preparation method for the Chinese soapberry fruit ether extract disclosed by the invention is simple, the ether compound is adopted to carry out vibrating extraction on Chinese soapberry fruit peels, the in-vitro bacteriostatic experiment proves thatthe Chinese soapberry fruit ether extract has a good inhibitory effect on the propionibacterium acnes, the pharmaceutical application of Chinese soapberry fruits is broadened, and the invention can beapplied to the identification of Chinese soapberry fruit varieties and the monitoring of extract quality and lay a theoretical foundation for the development of medicines for treating acne.

Description

technical field [0001] The present invention relates to a method for extracting Sapindus chinensis extract, in particular to a Sapindus chinensis ether extract having inhibitory activity against Propionibacterium acnes, its preparation method, its detection method and its use, belonging to plant active ingredients technology field. Background technique [0002] Propionibacterium acnes (P.acnes) is one of the important factors causing acne, a skin disease. By colonizing the surface of human skin, the bacteria decompose sebum into free fatty acids, causing an inflammatory reaction in and around the hair follicles, leading to acne. [0003] As a worldwide public health problem, acne not only affects people's appearance, but also has a certain impact on people's emotional and mental health. It has become a psychosomatic disease that cannot be ignored. Currently, acne is mainly treated by taking antibiotics internally and externally. As we all know, the use of western medicine...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/77A61P31/04A61P17/10G01N30/02G01N30/06A61K131/00
CPCA61K36/77A61K2236/35A61P17/10A61P31/04G01N30/02G01N30/06
Inventor 姚卫蓉
Owner 南京福科帝生物科技有限公司
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