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Graphene oxide/lidocaine sponge dressing and preparation method thereof

A technology of lidocaine and lidocaine, which is applied in the field of graphene oxide/lidocaine sponge dressing and its preparation, can solve the problem that wound granulation tissue is easy to grow into the mesh of the dressing, hinders the epithelialization of tissue cells, and cannot maintain Wound wetting and other issues, to achieve the effect of scientific and reasonable material selection and proportioning, good biocompatibility, and excellent physical and chemical properties

Active Publication Date: 2018-08-17
万绵水
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] In view of the above situation, gauze is traditionally used as a medical dressing. Gauze has the advantages of protecting the wound surface, wide sources, simple production, and low price; but the disadvantages are also prominent: it cannot keep the wound moist, hinders the epithelialization of tissue cells, and delays wound healing; The fibers are easy to fall off, causing foreign body reactions and affecting healing; the wound granulation tissue is easy to grow into the mesh of the dressing, and it is easy to cause pain when changing the dressing; the hemostatic effect is not good, and the pathogens are easy to penetrate; the new tissue is easy to be damaged when changing the dressing; changing the dressing heavy workload

Method used

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  • Graphene oxide/lidocaine sponge dressing and preparation method thereof

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preparation example Construction

[0025] In addition, for the sponge dressing of the present invention, the applicant specifically provides a preparation method, such as figure 1 As shown, including the following steps:

[0026] S101: Add polyvinyl alcohol to 5-10 times the amount of deionized water, gradually stir and raise the temperature to 90° C. to completely dissolve, and then cool to room temperature to obtain a polyvinyl alcohol aqueous solution.

[0027] S102: Add the graphene oxide / lidocaine inclusion compound to the polyvinyl alcohol aqueous solution and stir evenly to obtain a graphene oxide / lidocaine polyvinyl alcohol blend.

[0028] S103: Add a foaming agent to the graphene oxide / lidocaine polyvinyl alcohol blend, and stir thoroughly.

[0029] S104: Add catalyst to the solution obtained in S103, and stir at 25-30°C for 3-5 min.

[0030] S105: After adding a crosslinking agent to the product obtained in S104, the reaction is continued for 20-25 minutes, and the reaction product is baked at 50-70°C to form,...

Embodiment 1

[0036] This embodiment provides a method for preparing graphene oxide, including the following steps: preparing graphite into graphene oxide, placing 3 g of graphite powder in a 500 mL single-neck flask, then adding 300 mL of mixed acid of sulfuric acid and phosphoric acid, and slowly adding permanganic acid Potassium, sealed with a sealing film at 50℃, stirred and reacted for 15h, cooled to room temperature with 400mL ice-water bath, and added 30% hydrogen peroxide in the ice-water bath, adding from fast to slow until the solution turned bright yellow , Low-speed centrifugation; transfer the centrifugal product to a beaker, add hydrochloric acid and centrifuge for 2 times, add ethanol for centrifugal washing 2 times, and wash with deionized water for 6 times until the pH of the supernatant reaches neutrality, then freeze-dry the product That is graphene oxide.

Embodiment 2

[0038] Based on the graphene oxide prepared in Example 1, this example provides a method for preparing a graphene oxide / lidocaine inclusion compound, which includes the following steps:

[0039] Take 50 mg of graphene oxide into 25 mL of deionized water and ultrasonically treat for 30 min, transfer the graphene oxide solution to a 100 mL round bottom flask to obtain a graphene oxide dispersion. Weigh 200 mg of lidocaine hydrochloride, dissolve it in 3 mL of absolute ethanol, then add 7 mL of graphene oxide dispersion, sonicate for 30 minutes, and the ultrasonic power is 400W, the frequency is 40kHz; after that, stir overnight and adjust the pH to below 6 to prepare Graphene oxide / lidocaine inclusion compound with a concentration of 20 mg / mL; then placed in a refrigerator at 4°C for use.

[0040] The graphene oxide / lidocaine inclusion compound prepared in Example 2 is used in the preparation process of the sponge dressing, which specifically includes the following examples:

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Abstract

The invention discloses a graphene oxide / lidocaine sponge dressing and a preparation method thereof. The sponge dressing is prepared from the following raw material components: 20 to 500g of polyvinylalcohol, 1 to 20mL of graphene oxide / lidocaine inclusion complex, 0.01 to 15g of foaming agent, 10 to 400mL of catalyst and 10 to 400mL of cross-linking agent, wherein the concentration of the graphene oxide / lidocaine inclusion complex is 5 to 20mg / mL. Compared with the prior art, the medical sponge dressing integrates the excellent performance of graphene oxide, lidocaine, polyvinyl alcohol andthe like, has the advantages of rapid liquid absorbing, large liquid absorbing amount, large moisture-locking amount, antibacterial activity, analgesis, flexibility, high elasticity and the like, andcan be used for quickly treating wounded skin of a patient and reducing the huge pain caused by the wound surface. In addition, the medical sponge dressing provided by the invention is simple in production process, low in cost, easy to realize industrial production, and has wide application value.

Description

Technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a graphene oxide / lidocaine sponge dressing and a preparation method thereof. Background technique [0002] In recent years, with the rapid development of the transportation industry, petrochemical industry, construction industry, etc., the incidence, disability and death rate of burns in work and daily life have been increasing year by year. According to statistics, burns rank second in the number of deaths due to accidental injuries in my country each year, second only to traffic accidents. Among them, the annual incidence of burns in my country is about 2%, and about 5% of burn patients require hospitalization, and about 10% of hospitalized burn patients suffer from various degrees of disability. This is a heavy burden on patients, their families, and society. Major issues related to family happiness and social stability. Therefore, when the skin is injured, it should ...

Claims

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Application Information

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IPC IPC(8): A61L15/20A61L15/18A61L15/24A61L15/42A61L15/44A61L15/46
CPCA61L15/18A61L15/20A61L15/24A61L15/42A61L15/425A61L15/44A61L15/46A61L2300/402A61L2300/404A61L2300/602A61L2400/12C08L29/04
Inventor 万绵水
Owner 万绵水