Molybdenum disulfide nano-sheet in-situ modified biological ceramic stent, preparation method and applications thereof

A molybdenum disulfide, in-situ modification technology, used in pharmaceutical formulations, tissue regeneration, medical preparations containing active ingredients, etc., can solve problems such as difficult self-healing of the body and tissue defects

Active Publication Date: 2018-09-07
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In addition, surgical resection of the tumor will cause large tissue defects, which are difficult for the body to heal itself, requ

Method used

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  • Molybdenum disulfide nano-sheet in-situ modified biological ceramic stent, preparation method and applications thereof
  • Molybdenum disulfide nano-sheet in-situ modified biological ceramic stent, preparation method and applications thereof
  • Molybdenum disulfide nano-sheet in-situ modified biological ceramic stent, preparation method and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069] (1) After taking 5g of pure feldspar powder (Kunshan Huaqiao Technology New Material Co., Ltd.), 0.32g of sodium alginate powder and 2.5g of F127 aqueous solution with a mass fraction of 20%, the scaffold material was prepared by using three-dimensional printing technology;

[0070] (2) Calcinate the printed support at 1350°C for 3 hours to obtain a pure feldspar ceramic support AKT, the size of which is Ф11mmⅹ3mm;

[0071] (3) Add 1mmol ammonium molybdate tetrahydrate and 30mmol thiourea into 35mL deionized water to obtain a solution with a molar concentration of molybdenum atoms of 0.2mol / L. After stirring for 1 hour, pour it into the polytetrafluoroethylene 4g feldspar ceramic support. In the lining of the ethylene hydrothermal kettle, a black bracket was obtained after a 180°C hydrothermal reaction for 24 hours;

[0072] (4) After washing several times with ethanol and water, and drying in a vacuum oven at 60°C, a molybdenum disulfide-modified feldspar scaffold 0.2M...

Embodiment 2

[0086] (1) After fully mixing 5g of pure feldspar powder, 0.32g of sodium alginate powder and 2.5g of F127 aqueous solution with a mass fraction of 20%, the scaffold material was prepared by three-dimensional printing technology;

[0087] (2) Calcinate the printed support at 1350°C for 3 hours to obtain a pure feldspar ceramic support AKT, the size of which is Ф11mmⅹ3mm;

[0088] (3) Add 0.5mmol ammonium molybdate tetrahydrate and 15mmol thiourea into 35mL deionized water to obtain a solution with a molar concentration of molybdenum atoms of 0.1mol / L. After stirring for 1 hour, pour it into polytetrafluoroethylene with 4g feldspar ceramic support. In the lining of vinyl fluoride hydrothermal kettle, a black bracket was obtained after 180°C hydrothermal reaction for 24 hours;

[0089] (4) After washing several times with ethanol and water, and drying in a vacuum oven at 60°C, a molybdenum disulfide-modified feldspar scaffold 0.1MS-AKT was obtained;

[0090] (5) Place the stent...

Embodiment 3

[0094] (1) After fully mixing 5g of pure feldspar powder, 0.32g of sodium alginate powder and 2.5g of F127 aqueous solution with a mass fraction of 20%, the scaffold material was prepared by three-dimensional printing technology;

[0095] (2) Calcinate the printed support at 1350°C for 3 hours to obtain a pure feldspar ceramic support AKT, the size of which is Ф11mmⅹ3mm;

[0096] (3) 0.25mmol ammonium molybdate tetrahydrate and 7.5mmol thiourea were added into 35mL deionized water to obtain a molar concentration of molybdenum atom molar solution that was 0.05mol / L. After stirring for 1 hour, pour 4g feldspar ceramic support into the poly In the lining of tetrafluoroethylene hydrothermal kettle, a black bracket was obtained after hydrothermal reaction at 180°C for 24 hours;

[0097](4) After washing several times with ethanol and water, and drying in a vacuum oven at 60°C, a molybdenum disulfide-modified feldspar scaffold 0.05MS-AKT was obtained;

[0098] (5) Place the stent i...

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Abstract

The invention relates to a molybdenum disulfide nano-sheet in-situ modified biological ceramic stent, a preparation method and applications thereof, wherein the molybdenum disulfide nano-sheet in-situmodified biological ceramic stent comprises an akermanite bioactive ceramic stent and molybdenum disulfide nano-sheets growing on the surface of the akermanite bioactive ceramic stent in situ. According to the present invention, the molybdenum disulfide nano-sheet in-situ modified biological ceramic stent is expected to be used as the multifunctional implantation material for repairing tissue defects and treating tumors in clinical application.

Description

technical field [0001] The invention relates to molybdenum disulfide nanosheet in-situ modified bioceramic support and its preparation method and application, belonging to the field of biological materials. Background technique [0002] Malignant tumors have become the second cause of human death (after cardiovascular disease), and finding effective treatments has always been a global problem that plagues modern medicine[1,2]. The current common clinical treatment for solid tumors is surgical resection combined with radiation therapy (radiotherapy) and chemotherapy (chemotherapy) [3]. Because surgical resection is difficult to completely remove tumor cells, traditional chemotherapy and radiotherapy are usually used, and radiotherapy and chemotherapy will cause serious side effects to patients[4,5]. Photothermal therapy is a treatment method that uses materials with high photothermal conversion efficiency to rapidly heat up under the irradiation of an external light source (...

Claims

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Application Information

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IPC IPC(8): A61L27/10A61L27/30A61L27/50A61L27/54A61K41/00
CPCA61K41/0052A61L27/10A61L27/306A61L27/50A61L27/54A61L2300/10A61L2300/606A61L2420/02A61L2430/02
Inventor 吴成铁王小成常江金晓刚
Owner SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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