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Molybdenum disulfide nano-sheet in-situ modified biological ceramic stent, preparation method and applications thereof

A molybdenum disulfide, in-situ modification technology, used in pharmaceutical formulations, tissue regeneration, medical preparations containing active ingredients, etc., can solve problems such as difficult self-healing of the body and tissue defects

Active Publication Date: 2018-09-07
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In addition, surgical resection of the tumor will cause large tissue defects, which are difficult for the body to heal itself, requiring reimplantation of allogeneic tissues, artificial tissues or prostheses for defect repair and tissue function reconstruction[9]

Method used

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  • Molybdenum disulfide nano-sheet in-situ modified biological ceramic stent, preparation method and applications thereof
  • Molybdenum disulfide nano-sheet in-situ modified biological ceramic stent, preparation method and applications thereof
  • Molybdenum disulfide nano-sheet in-situ modified biological ceramic stent, preparation method and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069] (1) After taking 5g of pure feldspar powder (Kunshan Huaqiao Technology New Material Co., Ltd.), 0.32g of sodium alginate powder and 2.5g of F127 aqueous solution with a mass fraction of 20%, the scaffold material was prepared by using three-dimensional printing technology;

[0070] (2) Calcinate the printed support at 1350°C for 3 hours to obtain a pure feldspar ceramic support AKT, the size of which is Ф11mmⅹ3mm;

[0071] (3) Add 1mmol ammonium molybdate tetrahydrate and 30mmol thiourea into 35mL deionized water to obtain a solution with a molar concentration of molybdenum atoms of 0.2mol / L. After stirring for 1 hour, pour it into the polytetrafluoroethylene 4g feldspar ceramic support. In the lining of the ethylene hydrothermal kettle, a black bracket was obtained after a 180°C hydrothermal reaction for 24 hours;

[0072] (4) After washing several times with ethanol and water, and drying in a vacuum oven at 60°C, a molybdenum disulfide-modified feldspar scaffold 0.2M...

Embodiment 2

[0086] (1) After fully mixing 5g of pure feldspar powder, 0.32g of sodium alginate powder and 2.5g of F127 aqueous solution with a mass fraction of 20%, the scaffold material was prepared by three-dimensional printing technology;

[0087] (2) Calcinate the printed support at 1350°C for 3 hours to obtain a pure feldspar ceramic support AKT, the size of which is Ф11mmⅹ3mm;

[0088] (3) Add 0.5mmol ammonium molybdate tetrahydrate and 15mmol thiourea into 35mL deionized water to obtain a solution with a molar concentration of molybdenum atoms of 0.1mol / L. After stirring for 1 hour, pour it into polytetrafluoroethylene with 4g feldspar ceramic support. In the lining of vinyl fluoride hydrothermal kettle, a black bracket was obtained after 180°C hydrothermal reaction for 24 hours;

[0089] (4) After washing several times with ethanol and water, and drying in a vacuum oven at 60°C, a molybdenum disulfide-modified feldspar scaffold 0.1MS-AKT was obtained;

[0090] (5) Place the stent...

Embodiment 3

[0094] (1) After fully mixing 5g of pure feldspar powder, 0.32g of sodium alginate powder and 2.5g of F127 aqueous solution with a mass fraction of 20%, the scaffold material was prepared by three-dimensional printing technology;

[0095] (2) Calcinate the printed support at 1350°C for 3 hours to obtain a pure feldspar ceramic support AKT, the size of which is Ф11mmⅹ3mm;

[0096] (3) 0.25mmol ammonium molybdate tetrahydrate and 7.5mmol thiourea were added into 35mL deionized water to obtain a molar concentration of molybdenum atom molar solution that was 0.05mol / L. After stirring for 1 hour, pour 4g feldspar ceramic support into the poly In the lining of tetrafluoroethylene hydrothermal kettle, a black bracket was obtained after hydrothermal reaction at 180°C for 24 hours;

[0097](4) After washing several times with ethanol and water, and drying in a vacuum oven at 60°C, a molybdenum disulfide-modified feldspar scaffold 0.05MS-AKT was obtained;

[0098] (5) Place the stent i...

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Abstract

The invention relates to a molybdenum disulfide nano-sheet in-situ modified biological ceramic stent, a preparation method and applications thereof, wherein the molybdenum disulfide nano-sheet in-situmodified biological ceramic stent comprises an akermanite bioactive ceramic stent and molybdenum disulfide nano-sheets growing on the surface of the akermanite bioactive ceramic stent in situ. According to the present invention, the molybdenum disulfide nano-sheet in-situ modified biological ceramic stent is expected to be used as the multifunctional implantation material for repairing tissue defects and treating tumors in clinical application.

Description

technical field [0001] The invention relates to molybdenum disulfide nanosheet in-situ modified bioceramic support and its preparation method and application, belonging to the field of biological materials. Background technique [0002] Malignant tumors have become the second cause of human death (after cardiovascular disease), and finding effective treatments has always been a global problem that plagues modern medicine[1,2]. The current common clinical treatment for solid tumors is surgical resection combined with radiation therapy (radiotherapy) and chemotherapy (chemotherapy) [3]. Because surgical resection is difficult to completely remove tumor cells, traditional chemotherapy and radiotherapy are usually used, and radiotherapy and chemotherapy will cause serious side effects to patients[4,5]. Photothermal therapy is a treatment method that uses materials with high photothermal conversion efficiency to rapidly heat up under the irradiation of an external light source (...

Claims

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Application Information

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IPC IPC(8): A61L27/10A61L27/30A61L27/50A61L27/54A61K41/00
CPCA61K41/0052A61L27/10A61L27/306A61L27/50A61L27/54A61L2300/10A61L2300/606A61L2420/02A61L2430/02
Inventor 吴成铁王小成常江金晓刚
Owner SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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