Electrified composite membrane with extracellular matrix electrical topology characteristics, and preparation method thereof

A technology of topological features and composite membranes, applied in medical science, tissue regeneration, bone implants, etc., can solve the problems of poor matching of natural extracellular matrix characteristics and limited repair effect of materials, and achieve good electrical compatibility, Good inductive bone repair performance and high productivity

Active Publication Date: 2018-09-07
PEKING UNIV SCHOOL OF STOMATOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Aiming at the technical problems of poor matching between the electrical characteristics of the material and the characteristics of the natural extracellular matrix and the limited repair effect of the material, the invention provides a charged composite membrane with the electrical topological characteristics of the extracellular matrix and its preparation method

Method used

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  • Electrified composite membrane with extracellular matrix electrical topology characteristics, and preparation method thereof
  • Electrified composite membrane with extracellular matrix electrical topology characteristics, and preparation method thereof
  • Electrified composite membrane with extracellular matrix electrical topology characteristics, and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] (1) Take 9ml of glacial acetic acid and 1.340g of acetylacetone, mix and stir for 5min, add 1.703g of barium acetate, stir for 1h, add 2.266g of tetrabutyl titanate, stir for 15min, then add 0.45g of polyvinylpyrrolidone (PVP), stir 3h;

[0040] (2) inject the mixed solution obtained in step (1) into the syringe, and use electrospinning technology under the condition of voltage 14kV to obtain barium titanate nanofibers with a diameter of 200nm;

[0041] (3) Put the barium titanate nanofibers obtained in step (2) into 0.01mol / L dopamine aqueous solution, heat and stir in a 60-degree water bath for 12 hours, then ultrasonically oscillate for 5 minutes, and obtain titanic acid with an aspect ratio of 12 after centrifugal drying Barium nanofiber filler;

[0042] (4) Take an appropriate amount of the barium titanate nanofiber filler obtained in step (3) and disperse it in 3mL of organic solvent DMF by ultrasonic oscillation, and use ultrasonic oscillation combined with stir...

Embodiment 2

[0053] (1) Take 9ml of glacial acetic acid and 1.340g of acetylacetone, mix and stir for 5min, add 1.703g of barium acetate, stir for 1h, add 2.266g of tetrabutyl titanate, stir for 15min, then add 0.45g of polyvinylpyrrolidone (PVP), stir 3h;

[0054] (2) inject the mixed solution obtained in step (1) into the syringe, and use electrospinning technology under the condition of voltage 16kV to obtain barium titanate nanofibers with a diameter of 300nm;

[0055] (3) Put the barium titanate nanofibers obtained in step (2) into 0.05mol / L dopamine aqueous solution, heat and stir in a 60-degree water bath for 12 hours, then ultrasonically vibrate for 10 minutes, and obtain barium titanate with an aspect ratio of 8 after centrifugal drying nanofiber filler;

[0056] (4) Take an appropriate amount of the barium titanate nanofiber filler obtained in step (3) and disperse it in 3mL of organic solvent DMF by ultrasonic oscillation, and use ultrasonic oscillation combined with stirring f...

Embodiment 3

[0067] (1) Take 9ml of glacial acetic acid and 1.340g of acetylacetone, mix and stir for 5min, add 1.703g of barium acetate, stir for 1h, add 2.266g of tetrabutyl titanate, stir for 15min, then add 0.45g of polyvinylpyrrolidone (PVP), stir 3h;

[0068] (2) inject the mixed solution obtained in step (1) into the syringe, and use electrospinning technology under the condition of voltage 12kV to obtain barium titanate nanofibers with a diameter of 400nm;

[0069] (3) Put the barium titanate nanofibers obtained in step (2) into 0.08mol / L dopamine aqueous solution, heat and stir in a 60-degree water bath for 12 hours, then ultrasonically vibrate for 1 minute, and obtain barium titanate with an aspect ratio of 20 after centrifugal drying nanofiber filler;

[0070] (4) Take an appropriate amount of the barium titanate nanofiber filler obtained in step (3) and disperse it in 3mL of organic solvent DMF by ultrasonic oscillation, and use ultrasonic oscillation combined with stirring fo...

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Abstract

The invention relates to an electrified composite membrane with extracellular matrix electrical topology characteristics, and a preparation method thereof, and solves the technical problems that the electrical characteristics of a traditional material has poor matching performance with natural extracellular matrix characteristics and a material repairing effect is restricted. The electrified composite membrane with extracellular matrix electrical topology characteristics mainly consists of a ferroelectric polymer matrix and piezoelectric active fiber filler. According to the electrified composite membrane, the draw ratio and the content of the piezoelectric active fiber and the thickness of the composite membrane are regulated, the flexibility of a membrane material and biomimetic extracellular matrix electrical topology characteristics can be realized, and the electrified composite membrane has the advantages of good tissue attachment performance, good electrical adaptability and highclinic operability.

Description

technical field [0001] The invention relates to the technical field of orthopedic and oral surgery repair materials, in particular to a charged composite film with extracellular matrix electrical topological characteristics and a preparation method thereof. Background technique [0002] Implant repair is currently the main method for treating large-scale tissue defects. Artificial repair materials have received extensive attention in tissue repair materials due to their wide range of sources, controllable performance and low cost. According to the principle of bionics, damage potential exists in skin wound healing, nerve repair, bone defect repair, etc. A large number of studies have confirmed that damage potential plays an important role in tissue repair. Healing and functional restoration. In recent years, electroactive materials have become a research hotspot and trend, and they are also a new idea for the design of tissue repair materials. [0003] However, the curren...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/50A61L27/02A61L27/16
CPCA61L27/025A61L27/16A61L27/50A61L2430/02C08L27/16A61F2/28A61F2/2875A61F2002/2835A61L27/446A61L31/128A61L31/14A61F2240/001
Inventor 邓旭亮白云洋张学慧
Owner PEKING UNIV SCHOOL OF STOMATOLOGY
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