A naphthoquinone compound and its preparation and application in the preparation of hypoglycemic products

A compound and blood sugar-lowering technology, applied in the field of natural medicinal chemistry, to achieve rich nutrition, good medicinal and dietary effects, and remarkable curative effect
CN108503653BInactive Publication Date: 2019-06-07NANYANG NORMAL UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
NANYANG NORMAL UNIV
Publication Date
2019-06-07
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention belongs to the field of natural pharmaceutical chemistry and particularly relates to naphthoquinone compounds, preparation thereof and an application to hypoglycemic product preparation.The chemical structural formula of the naphthoquinone compounds is shown as formula I in the description. Preparation comprises the following steps: Eleocharis dulcis is ground and then subjected toheat reflux extraction, and total Eleocharis dulcis extract is obtained; extraction is performed with cyclohexane and ethyl acetate sequentially, an extract is separated and purified by a silica gel chromatographic column, a Sephadex LH-20 gel column, a Toyopearl HW-40 column and a semi-preparative liquid phase C18 column, and the naphthoquinone compounds are obtained. The naphthoquinone compoundsare novel in structure and have better hypoglycemic activity which is higher than that of positive control acarbose, and an important material basis is laid for development of hypoglycemic drugs withremarkable curative effect and few toxic and side effects from medicinal and edible plants in future.
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Description

technical field

[0001] The invention belongs to the field of natural medicinal chemistry, and in particular relates to a naphthoquinone compound and its preparation and application in the preparation of hypoglycemic products. Background technique

[0002] Water chestnut (Heleocharis dulcis), commonly known as horseshoe and ground chestnut, is a perennial shallow water herb of Cyperaceae. As a kind of food with both medicine and food, it has tender meat, juicy and sweet taste, crisp and refreshing. It has the reputation of "Underground Sydney" since ancient times and is deeply loved by people. Every 100g of fresh water chestnuts contains 68g of water, 21.8g of carbohydrates, 1.5g of protein, 0.1g of fat, 0.5g of crude fiber, 5mg of calcium, 68mg of phosphorus, 0.5mg of iron, 0.01mg of carotene, and vitamin BB 1 0.04mg, vitamin B 2 0.02mg, Vitamin C 3mg, Niacin 0.4mg, etc. "Compendium of Materia Medica" records that water chestnuts can reduce fire, nourish the lungs and c...

Claims

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