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A kind of Tongluozhitong gel preparation and preparation method thereof

A technology of gel preparation, dredging collaterals and relieving pain, which is applied in the direction of non-central analgesics, anti-inflammatory agents, pharmaceutical formulations, etc., and can solve the problem of drug curative effect. And other problems, to achieve the effect of good transdermal effect, high drug loading, and prevent volatilization

Active Publication Date: 2021-04-30
王庆普 +3
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, there are few traditional Chinese medicine gel preparations specially acting on degenerative diseases in the market, and most of the existing traditional Chinese medicine external dosage forms are single-solvent solutions, or concentrates, or creams, with less active ingredient content and poor transdermal effect. In addition, In the existing preparation process of traditional Chinese medicine gel preparations, the volatile components contained in the medicine are greatly lost during the production process, which greatly reduces the curative effect of the medicine and the drug loading capacity of the gel preparation.

Method used

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  • A kind of Tongluozhitong gel preparation and preparation method thereof
  • A kind of Tongluozhitong gel preparation and preparation method thereof
  • A kind of Tongluozhitong gel preparation and preparation method thereof

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preparation example Construction

[0045] Step 1, the preparation of cinnamaldehyde liposome suspension:

[0046] Weigh cinnamon aldehyde extract and liposome auxiliary material, the weight ratio of cinnamon aldehyde extract and liposome auxiliary material is 1:8~1:32, the liposome auxiliary material is cholesterol and lecithin, wherein the weight ratio of cholesterol and lecithin 1:6~1:12, add in absolute ethanol to dissolve, add phosphate buffer solution with pH value of 6.6~7.4 for hydration after rotary evaporation, hydration temperature is 55°C to 65°C, heat and rotate in water bath, ultrasonic After 5 minutes, a milky white homogeneous suspension was obtained, then filtered and collected, and stored at 4°C;

[0047] Step 2, preparation of decoction:

[0048] Weigh 160 parts of monarch drug and 153 parts of auxiliary drug A, add distilled water to soak for 1-3 hours, filter out the liquid medicine for later use; then add distilled water, decoct for 20-40 minutes, and filter out the medicine liquid for lat...

Embodiment 1

[0055] The ratio of cinnamon aldehyde extract to the total amount of liposome excipients is 1:16, and the ratio of liposome excipient components, namely the ratio of cholesterol to lecithin, is 1:6. Choose 10 mg of cinnamon aldehyde extract, 22.86 mg of cholesterol, and 137.14 mg of lecithin , phosphate buffer solution pH 7.4, hydration temperature 55°C, make cinnamon aldehyde liposome suspension according to the preparation method of Tongluozhitong gel preparation and take 100ml, measure 1000ml of carbomer base, and mix them in turn Described cinnamon aldehyde liposome suspension 100ml, described Chinese medicine decoction 50ml, adjuvant B fine powder 20g, make the gel for dredging collaterals and relieving pain.

Embodiment 2

[0057] The ratio of cinnamon aldehyde extract to the total amount of liposome excipients is 1:16, and the ratio of liposome excipient components, namely the ratio of cholesterol to lecithin, is 1:8. Choose 10 mg of cinnamon aldehyde extract, 17.78 mg of cholesterol, and 142.22 mg of lecithin , phosphate buffer solution pH 7.4, hydration temperature 55°C, make cinnamon aldehyde liposome suspension according to the preparation method of Tongluozhitong gel preparation and take 100ml, measure 1000ml of carbomer base, and mix them in turn Described cinnamon aldehyde liposome suspension 100ml, described Chinese medicine decoction 50ml, adjuvant B fine powder 20g, make the gel for dredging collaterals and relieving pain.

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Abstract

The invention provides a gel preparation for dredging collaterals and relieving pain and a preparation method thereof. The preparation includes cinnamon aldehyde liposomes, Chinese medicine extracts, and a gel matrix, which greatly retains the active pharmaceutical ingredients of the Chinese medicine extracts. At the same time, the invention also provides The preparation method for preparing the gel preparation is provided, including the preparation of cinnamon aldehyde liposome suspension, the preparation of water decoction, the preparation of adjuvant B fine powder, and the preparation of Tongluozhipain gel preparation. The present invention The preparation of the gel preparation according to the compatibility characteristics of the drugs for dredging collaterals and relieving pain can effectively lock the active ingredients of the drugs and retain the efficacy of the drugs.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, and relates to a traditional Chinese medicine gel preparation and a preparation method thereof, in particular to a collateral dredging and analgesic gel preparation and a preparation method thereof. Background technique [0002] Knee osteoarthritis is a common chronic progressive bone and joint disease among middle-aged and elderly people. It has a high morbidity rate and a high disability rate. economic burden. The age of onset is 40-50 years old for women and 50-60 years old for men. With the aging process of our country, there are a large number of patients with knee osteoarthritis among the elderly population. [0003] The etiology of the disease is complex, the pathogenesis is unknown, and there is a lack of specific treatment. The currently recognized treatment principle in the field of orthopedics is: according to the degree of degeneration of the knee j...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/06A61K36/758A61P29/00A61P19/02A61P19/08A61K31/11
CPCA61K9/0014A61K9/06A61K31/11A61K36/21A61K36/268A61K36/286A61K36/324A61K36/328A61K36/54A61K36/65A61K36/71A61K36/714A61K36/736A61K36/758A61K47/28A61K2236/331A61K2236/39A61P19/02A61P19/08A61P29/00A61K2300/00
Inventor 王庆普
Owner 王庆普
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