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A kind of preparation method of Shenling Baizhu granule

A technology of Shenling Baizhu and granules, applied in the field of traditional Chinese medicine preparations, can solve the problems of poor particle size uniformity, low granulation efficiency, safety risk and environmental pollution, etc.

Active Publication Date: 2021-09-10
BEIJING HANDIAN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In the granulation process disclosed in the preparation method of the above-mentioned patent, ethanol is used as a wetting agent, and the amount of ethanol used is relatively large. It takes about 350Kg of ethanol to produce 1000Kg of granules, and these ethanols need to be dried in the granule drying process. After heating and evaporating, it is discharged as waste gas; thus increasing the production cost of the product and the cost of waste gas VOC treatment, there are also safety risks and environmental pollution risks
[0005] In addition, the existing granulation process of Shenling Baizhu Granules uses a swing granulator for granulation, which has low granulation efficiency, poor particle size uniformity, and more fine powder and dust in the granulation process

Method used

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Effect test

preparation example Construction

[0047] Preparation of Shenling Baizhu Powder :

[0048] Amomum 200g extracts volatile oil; dregs of ginseng 400g, Atractylodes macrocephala (stir-fried) 400g plus 4 times the amount of 95% ethanol are soaked for 24 hours, refluxed for 3 hours, filtered, ethanol is recovered from the filtrate, and concentrated to obtain the alcohol extract. Add 4 times the amount of 50% ethanol to the dregs of the medicine, reflux for 3 hours, filter, recover the ethanol from the filtrate, concentrate to obtain the alcohol extract, and use the dregs of the medicine for later use; take 200g of coix seed (stir-fried), 200g of lotus seeds, and 300g of white hyacinth bean (stir-fried) , Platycodon grandiflorum 200g, licorice 400g, Poria cocos 400g add 8 times the amount of water to boil for 2 hours, filter, the dregs and the above-mentioned spare residue after alcohol extraction add 8 times the amount of water to boil together for 1.5 hours, filter, combine the two filtrates and The above-mentione...

Embodiment 1

[0049] Embodiment 1 Preparation of Shenling Baizhu Granules of the present invention

[0050] The first step: making soft material

[0051] Add 0.6Kg of water to 4Kg of lactose, mix thoroughly, and if there is agglomeration, use a 40-mesh stainless steel sieve to sieve.

[0052] Add 10Kg of Shenlingbaizhu medicinal powder to the above-mentioned lactose that has been evenly moistened, and mix quickly and evenly.

[0053] The second step: rotary extrusion granulation

[0054] Install the sieve plate with a hole diameter of 1.8mm on the rotary granulator, add the above-mentioned soft materials into the hopper of the rotary granulator in stages, turn on the rotary granulator, and the soft materials will pass through the sieve hole of the granulator Extrude to form round pellets.

[0055] The extruded round granules are crushed by the granulator of the rotary granulator to form uniform columnar wet granules.

[0056] Step 3: Particle Drying

[0057] Use a boiling dryer to dry ...

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Abstract

The invention provides a method for preparing Shenlingbaizhu granules with an improved granulation process. In the method, after mixing Shenlingbaizhu medicinal powder with lactose and water to obtain a soft material, the rotary granulator is used to extrude and granulate. The Shenlingbaizhu granules prepared by the invention have uniform particle size, rapid dissolution, no material compaction and screen mesh bonding phenomenon in the granulation process, and no use and discharge of ethanol in the granulation process. The process of the invention has high granulation efficiency, safety, environmental protection and economy. The Shenling Baizhu granule prepared by the method of the invention has less dosage, good taste, high bioavailability, convenient taking and good stability.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine preparations, in particular to a preparation method of Shenling Baizhu granules with an improved granulation process. Background technique [0002] Shenlingbaizhu granule, derived from "Chinese Pharmacopoeia", has the effect of invigorating the spleen and stomach and benefiting lung qi. It is used for weak spleen and stomach, lack of food, loose stools, shortness of breath, cough, and limb fatigue. The prescription consists of: ginseng 400g, Poria 400g, bran-fried Atractylodes macrocephala 400g, yam 400g, fried white lentils 300g, lotus seeds 200g, bran-fried coix seed 200g, amomum 200g, bellflower 200g, licorice 400g. [0003] The preparation method of Shenlingbaizhu granules disclosed in Chinese invention patent ZL 200510086669.8 is as follows: (1) extract volatile oil from 200 g of amomum by steam distillation, and collect the distilled aqueous solution in another container; Soak in...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K36/9064A61P1/14A61P11/00A61P1/12A61P11/14A61P39/00
CPCA61K9/1623A61K9/1682A61K36/076A61K36/258A61K36/284A61K36/346A61K36/48A61K36/484A61K36/62A61K36/8945A61K36/8994A61K36/9064A61K2236/331A61K2236/333A61K2236/51A61P1/12A61P1/14A61P11/00A61P11/14A61P39/00A61K2300/00
Inventor 林德良张礼
Owner BEIJING HANDIAN PHARMA CO LTD
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