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A method for enzymatically preparing sugar ester derivatives with antibacterial function

An enzymatic preparation and sugar ester technology, which is applied in the field of antibacterial sugar-based compound ester derivatives, can solve the problems of easy loss of antibacterial aroma components, weakened antibacterial durability, poor washability and the like, and achieves good antibacterial activity, Simple method and environmentally friendly effect

Active Publication Date: 2021-09-21
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, these fibers have poor washability, and the antibacterial aromatic components are easy to lose, so that the antibacterial durability is also weakened.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038]Pass the cellulose powder through a 100-mesh sieve, and dry the filtered cellulose at 80°C; evenly disperse the cellulose in the solvent tert-amyl alcohol, the amount of cellulose is 10% of the solvent mass, and use ultrasonic vibration for half an hour , and heated with magnetic stirring at 50°C for 2h to obtain a solvent system. At the same time, take 5 g of molecular sieves and put them into a muffle furnace for activation for 2 hours at a temperature of 300°C. While adding 5 g of molecular sieves to the solvent system, lipase and cinnamic acid were added, and the reaction time was 24 hours. The amount of lipase is 5.0% of the mass of cellulose, and the molar ratio of cinnamic acid to cellulose (calculated as anhydroglucose units, the same below) is 4:1. The reaction temperature is 50°C. Cool the obtained solution, filter the lipase with a 100-mesh sieve, then add absolute ethanol to wash, centrifuge, remove the supernatant, and vacuum-dry the obtained precipitate t...

Embodiment 2

[0040] Dry the cellulose fibers at 80°C; uniformly disperse the cellulose fibers in the solvent n-hexane, the amount of cellulose fibers is 5% of the solvent mass, oscillate with ultrasonic waves for half an hour, and heat at 50°C for 6 hours with magnetic stirring to obtain solvent system. At the same time, take 5 g of molecular sieves and put them into a muffle furnace for activation for 2 hours at a temperature of 300°C. Add molecular sieve, lipase and salicylic acid into the solvent system, and the reaction time is 36h. The dosage of lipase is 10% of the mass of cellulose fiber, the molar ratio of salicylic acid to cellulose fiber is 4:1, and the reaction temperature is 50°C. Cool the obtained solution, filter the lipase with a 100-mesh sieve, add absolute ethanol to wash, centrifuge, and vacuum-dry the obtained precipitate to obtain the required anti-mildew and antibacterial cellulose fiber. Tested by saponification titration method, the degree of substitution of the ob...

Embodiment 3

[0042] Dry the cellulose fibers at 80°C; evenly disperse the cellulose fibers in the solvent dimethyl sulfoxide, the amount of cellulose fibers is 10% of the solvent mass, use ultrasonic vibration for half an hour, and heat at 50°C with magnetic stirring 6h, the solvent system was obtained. At the same time, take 5 g of molecular sieves and put them into a muffle furnace for activation for 2 hours at a temperature of 300°C. Molecular sieves, lipase and p-aminobenzoic acid are added to the solvent system, and the reaction time is 48h. The dosage of lipase is 10% of the mass of cellulose fiber, the molar ratio of p-aminobenzoic acid to cellulose fiber is 4:1, and the reaction temperature is 50°C. Cool the obtained solution, filter the lipase with a 100-mesh sieve, add absolute ethanol to wash, centrifuge, and vacuum-dry the obtained precipitate to obtain the required anti-mildew and antibacterial cellulose fiber. As detected by saponification titration, the degree of substitut...

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Abstract

The invention discloses a method for enzymatically preparing sugar ester derivatives with antibacterial function. In this method, the glycosyl-containing compound is dispersed in an organic solvent, a mixed organic solvent, or a solvent-free system using an acyl donor as a solvent, and after mixing evenly, cinnamic acid or its derivatives, such as methoxycinnamic acid or its esterification product etc., heat the reaction in a water bath at 30°C~60°C for 6h~48h. After the reaction is finished, the lipase and the solvent are filtered off, and the product is obtained after drying. The modified sugar ester derivative has the antibacterial effect of inhibiting various molds. The enzymatic preparation of sugar ester derivatives of the present invention avoids the disadvantages of large chemical pollution and high equipment requirements, and has mild reaction conditions and good selectivity. It is used in antibacterial and mildew-proof paper products, textiles, food packaging materials, It is widely used in daily chemicals and food additives.

Description

technical field [0001] The invention belongs to the field of antibacterial sugar-based compound ester derivatives, and specifically relates to a method for enzymatically preparing sugar ester derivatives with antibacterial function. Background technique [0002] Sugars, including polysaccharides, monosaccharides, disaccharides, oligosaccharides, etc. Polysaccharides, such as cellulose, hemicellulose, starch, etc., are the most abundant biomass renewable resources in nature. Cellulose is the main component of paper products and textiles, but it has no antibacterial function by itself. In southern China, especially in South China, molds multiply rapidly in summer, and many fabrics and paper products will be polluted by molds. In addition, because people's skin is in contact with the outside world, microorganisms are often attached to them. Paper products and textiles inevitably absorb microorganisms and are easily polluted and moldy by harmful bacteria. Molds, even non-path...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12P19/04C12P19/44
CPCC12P19/04C12P19/44
Inventor 赵光磊何世军李晓凤
Owner SOUTH CHINA UNIV OF TECH