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Nano traditional Chinese medicine lipidosome hydrogel preparation for treating anorectal disease and preparation method

A kind of traditional Chinese medicine and nanotechnology, which is applied in liposome delivery, skin diseases, medical formulas, etc., can solve the problems of incurability, low cure rate, slow curative effect, etc., and achieve the effect of slow treatment, rapid curative effect and obvious effect

Inactive Publication Date: 2018-10-12
山东今古医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

And with the change of people's lifestyle, the age of onset is becoming younger, which has brought a huge burden to the society. It has become a common disease and frequently-occurring disease in society. The current treatment is mostly surgical treatment, but surgical treatment is harmful and painful. Large, long recovery period, and the current clinical lack of effective conservative treatment
Traditional Chinese medicine has a certain curative effect on anorectal diseases, but it has the characteristics of slow curative effect, long cycle, poor effect, and low cure rate. After treatment, it often leads to recurrence and cannot be cured, which greatly limits its clinical application.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1, the preparation method of nanometer traditional Chinese medicine liposome hydrogel preparation, comprises the steps:

[0025] 1. Preparation of Nano Chinese Medicine Liquid

[0026] 1.1 Weighing raw materials of traditional Chinese medicine: 15g of large thistle, 12g of small thistle, 16g of lotus leaf, 30g of oriental cypress leaf, 20g of chrysanthemum root, 20g of Qian root, 25g of mountain gardenia, 35g of rhubarb, 20g of peony bark, 15g of palm bark, 22g of white snake, chuanxiong 55g, borneol 15g. Put the above-mentioned traditional Chinese medicine into an ultra-fine jet mill, set the drug feeding speed to 50 g / min, adjust the crushing particle size to 50 nanometers, and finely pulverize the Chinese medicine decoction pieces.

[0027] 1.2 Put the above-mentioned ultrafinely pulverized traditional Chinese medicine powder in a traditional Chinese medicine ultrasonic extraction machine, add deionized water, the amount of water added is 8 times the weig...

Embodiment 2

[0035] Example 2, the preparation method of the nano traditional Chinese medicine liposome hydrogel preparation of this example is basically the same as that of Example 1, the difference is that the formula is different.

[0036] The formula of the hydrogel preparation in this example is: 18 parts of large thistle, 12 parts of small thistle, 22 parts of lotus leaf, 45 parts of arborvitae leaves, 12 parts of Chine root, 32 parts of Qian root, 15 parts of gardenia, 42 parts of rhubarb , 15 parts of peony bark, 8 parts of palm skin, 35 parts of white snake, 40 parts of Chuanxiong, 20 parts of borneol, 12 parts of lecithin, 15 parts of cholesterol, 39 parts of sodium alginate, 12 parts of glycerin, and 1000 parts of deionized water.

Embodiment 3

[0037] Embodiment 3, clinical application

[0038] The above-mentioned medicines have been rationally matched and effectively combined, and prepared by nano-Chinese medicine technology. They have a good effect on treating anorectal diseases. Painful, effective for clinical treatment of anorectal diseases and achieved satisfactory results. The relevant clinical data are as follows:

[0039] 1. Materials and methods

[0040] 1.1 Clinical data

[0041] A total of 115 patients with anorectal diseases were selected, among which 58 cases were set as the observation group and 57 cases were set as the control group.

[0042] Among the 58 patients in the observation group, there were 36 male patients and 22 female patients, aged 23-65 years, with an average age of (34.18±1.93) years. Among them, there were 37 patients with hemorrhoids (including internal hemorrhoids, external hemorrhoids, and mixed hemorrhoids), 12 patients with anal fissure, and 9 patients with perianal abscess.

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PUM

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Abstract

The invention provides a traditional Chinese medicine composition for treating the anorectal disease. The traditional Chinese medicine composition is prepared from the following raw materials by weight in parts: 12 to 20 parts of herba cirsii japonici, 10 to 15 parts of herba cepbalanoplosis segeti, 8 to 24 parts of lotus leaves, 20 to 50 parts of Chinese arborvitae twig, 10 to 30 parts of couch grass roots, 12 to 35 parts of madder roots, 10 to 36 parts of fructus gardeniae jasminoides, 24 to 60 parts of radix et rhizoma rhei, 12 to 36 parts of cortex moutan, 8 to 24 parts of palm bark, 18 to36 parts of long-noded pit viper, 36 to 80 parts of rhizoma Chuangxiong, and 12 to 20 parts of borneol. In addition, the invention also provides a nano traditional Chinese medicine lipidosome hydrogel preparation for treating the anorectal disease. The nano traditional Chinese medicine lipidosome hydrogel preparation is a nano microparticle preparation and is rapid in absorption, high in absorption rate, free from surgical operation, painless, invasive, capable of solving the weaknesses that the treatment of the traditional Chinese medicine is slow, the effect is poor and the treatment courseis long, good in efficacy, apparent in effect, rapid in curative effect and high in cure rate.

Description

technical field [0001] The invention relates to a nanometer traditional Chinese medicine liposome hydrogel preparation for clinically treating diseases, in particular to a nanometer traditional Chinese medicine liposome hydrogel preparation for treating anorectal diseases. Background technique [0002] In recent years, the incidence of anorectal diseases has been on the rise. China has entered an aging society, and the incidence is expected to increase further in the future. And with the change of people's lifestyle, the age of onset is becoming younger, which has brought a huge burden to the society. It has become a common disease and frequently-occurring disease in society. The current treatment is mostly surgical treatment, but surgical treatment is harmful and painful. Large, long recovery period, and the current clinical lack of effective conservative treatment. Traditional Chinese medicine has a certain curative effect on anorectal diseases, but it has the characteris...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A61K9/06A61K9/127A61K47/36A61P1/00A61P9/14A61P17/00A61K31/045A61K35/583
CPCA61K9/0014A61K9/06A61K9/127A61K31/045A61K35/583A61K36/14A61K36/236A61K36/28A61K36/62A61K36/65A61K36/708A61K36/71A61K36/74A61K36/744A61K36/889A61K36/899A61K47/36A61K2236/331A61P1/00A61P9/14A61P17/00A61K2300/00
Inventor 高鹏李立李倩
Owner 山东今古医疗科技有限公司