Probiotic chewing gum preparation method

A probiotics and chewing gum technology, applied in the field of probiotics chewing gum preparation, can solve the problems of flora system imbalance, emergence, drug-resistant strains and the like

Inactive Publication Date: 2018-10-19
NANCHANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The abuse of antibiotics may cause the imbalance of the original flora system while killing Streptococcus mutans, which will lead to more serious consequences and lead to the emergence of drug-resistant strains

Method used

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  • Probiotic chewing gum preparation method
  • Probiotic chewing gum preparation method
  • Probiotic chewing gum preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Embodiment 1: a kind of preparation method of probiotic chewing gum comprises the following steps:

[0015] (1) Cultivation of probiotics: Lactobacillus salivarius activated after secondary culture was selected and added to its MRS liquid medium according to the inoculum amount of 5% of the bacteria for 24-48 hours.

[0016] (2) Freeze-drying of probiotics: the cultured probiotics were centrifuged to collect the bacteria, and the bacteria were placed in a freeze dryer at -40°C and 4Pa for 48-72 hours; the collected freeze-dried powder was placed in a -70°C refrigerator Standby; the number of Lactobacillus salivarius in the freeze-dried powder is 10 11 pcs / g.

[0017] (3) Preparation of microcapsules: select sodium alginate as the main capsule material, use pectin as the auxiliary material, and mix according to the mass ratio of sodium alginate: pectin at 2:1, wherein the mixture of sodium alginate and pectin accounts for the total 2% by weight. Then add probiotic fre...

Embodiment 2

[0019] Embodiment 2: a kind of preparation method of probiotic chewing gum comprises the following steps:

[0020] (1) Cultivation of probiotics: select Bifidobacterium adolescent, Bifidobacterium bifidum, and Bifidobacterium animalis after secondary culture activation, and add them to its MRS liquid culture medium according to the 5% inoculation amount of each bacterium and cultivate them for 24 hours. -48 hours.

[0021] (2) Freeze-drying of probiotics: the cultured probiotics were centrifuged to collect the bacteria, and the bacteria were placed in a freeze dryer at -40°C and 4Pa for 48-72 hours; the collected freeze-dried powder was placed in a -70°C refrigerator Standby; the total quantity of Bifidobacterium adolescentis, Bifidobacterium bifidum, Bifidobacterium animalis in the lyophilized powder is 10 11 individual / g, the quantity ratio of the three kinds of probiotics is 1:1:1.

[0022] (3) Preparation of microcapsules: select sodium alginate as the main capsule mater...

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Abstract

The invention provides a probiotic chewing gum preparation method. By means of a probiotic embedding technology, survivability of probiotics in chewing gum is kept, and long-time storage is facilitated; by means of the characteristic of long chewing gum chewing time, retention time of probiotics in the oral cavity is prolonged; furthermore, the characteristic that the probiotics can antagonize pathogenic bacteria is utilized to inhibit and kill opportunistic pathogens in the oral cavity; finally, the purposes of preventing and treating oral diseases of ozostomia, pulpitis, periapical periodontitis, gingivitis, periodontitis, acute necrotic ulcerative periodontitis, stomatitis and the like are achieved. In addition, the probiotics can enter gastrointestinal tracts along with saliva to promote host gastrointestinal tract flora health and has recovering and treating effects on symptoms of unacclimatization, anorexia, diarrhea and the like of flora disorder diseases.

Description

technical field [0001] The invention relates to a preparation method of probiotic chewing gum which is specially used for preventing and treating oral flora disorder type diseases. Background technique [0002] Microorganisms can lead to oral diseases, such as pulpitis, periodontitis, gingivitis, periodontitis, acute necrotizing ulcerative periodontitis, stomatitis, etc. In the past, considering that Streptococcus mutans was often isolated from the lesion of dental caries patients, trying to use antibiotics to remove it has achieved the purpose of preventing caries, but the results have little effect. The reason is that Streptococcus mutans is one of the members of the normal flora in the oral cavity. To completely remove it, the operation is difficult, and the two will seriously damage the original micro-ecological balance of the oral cavity, resulting in flora imbalance. . Therefore, dental caries and periodontal disease are theoretically caused by the imbalance of norma...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/741A61K9/68A61K9/50A61P1/02A61P29/00
CPCA61K35/741A61K9/0058A61K9/5036A61P1/02A61P29/00
Inventor 陈廷涛
Owner NANCHANG UNIV
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