Polymer microneedle preparation system and method

A preparation system and polymer technology, applied in the field of new micro-precision molding processing of polymer materials, can solve the problems of high manufacturing cost, difficult batch preparation, large skin irritation, etc., and achieve mild manufacturing conditions, expand the scope of use, and simple equipment Effect

Active Publication Date: 2018-10-30
广州蔻原生物科技有限责任公司
View PDF10 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing preparation technology generally has low efficiency, complex manufacturing process, difficulty in batch preparation, and high manufacturing cost. The shape, structure, size uniformity and stability of the microneedles prepared at the same time are not ideal, and a single manufacturing method is not suitable for a variety of microneedle materials. and many more
[0009] (2) The drug-loading technology of microneedles is single and the application range is narrow
In the existing microneedle drug loading process, it is difficult to meet the loading requirements of water-soluble or fat-soluble drugs at the same time. The activity of the drug is significantly reduced, etc. Defects
[0010] (3) The adaptability of microneedles is poor
Existing metal and glass microneedle products have high physical and mechanical strength, large skin irritation, and damage to skin microvessels, resulting in redness or infection of the skin, and the remaining subcutaneous tissue of the broken tiny needle tip is difficult to remove and irritates the skin for a long time, causing a strong tingling sensation on the skin Make it difficult for consumers to accept, etc.
Microneedle products made of non-degradable polymer materials have good toughness but low mechanical strength. They are easy to bend during skin puncture and difficult to puncture the stratum corneum. The loading efficiency of water-soluble drugs is low, and often need to be used during processing. Organic solvents and organic solvents are difficult to remove, and the microneedles that enter the subcutaneous area are also difficult to remove and irritate tissues and other defects

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Polymer microneedle preparation system and method
  • Polymer microneedle preparation system and method
  • Polymer microneedle preparation system and method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] (1) Preparation of hyaluronic acid solution

[0062] The hyaluronic acid powder was added to the aqueous solution containing 1% sodium chloride under stirring, and the aqueous solution of hyaluronic acid (molecular weight 1000 000) was prepared by dissolving, stirring for 2 hours to prepare a concentrated solution of 10% by mass, and ultrasonically oscillating to remove the solution residual air bubbles.

[0063] (2) Preparation of hyaluronic acid microneedles

[0064] i. Add the prepared hyaluronic acid solution to the polymer solution storage tank of the polymer microneedle preparation system, turn on the metering delivery pump, and pump it into the microneedle plate mold.

[0065] ii. Turn on the scraper and adjust the height of the scraper, so that the scraper is driven by the motor to scrape the hyaluronic acid solution into a thin layer and evenly distribute it on the surface of the flat microneedle mold.

[0066] iii. Turn on the power of the high-voltage elect...

Embodiment 2

[0071] (1) Preparation of collagen solution

[0072] The collagen powder was added to an aqueous solution containing 0.5% acetic acid under stirring, and an aqueous solution of collagen (molecular weight 100 000) was prepared by dissolving, stirring for 2 hours to prepare a concentrated solution of 20% by mass, and ultrasonically oscillating to remove residual bubbles in the solution.

[0073] (2) Preparation of collagen microneedles

[0074] i. Add the prepared collagen solution into the polymer solution storage tank of the polymer microneedle preparation system, turn on the metering delivery pump, and pump it into the microneedle plate mold.

[0075]ii. Turn on the scraper and adjust the height of the scraper, so that the scraper is driven by the motor to scrape the collagen solution into a thin layer and evenly distribute it on the surface of the flat microneedle mold.

[0076] iii. Turn on the power of the high-voltage electric field generator, adjust the output voltage t...

Embodiment 3

[0081] (1) Preparation of chitosan solution

[0082] Add the chitosan powder to the 0.1% acetic acid aqueous solution under stirring, dissolve and prepare the chitosan (molecular weight 500 000) aqueous solution, stir for 6 hours, make a 15% mass percent concentrated solution, and remove the residual bubbles in the solution by ultrasonic vibration .

[0083] (2) Preparation of Chitosan Microneedles

[0084] i. Add the prepared chitosan solution into the polymer solution storage tank of the polymer microneedle preparation system, turn on the metering delivery pump, and pump it into the microneedle plate mold.

[0085] ii. Turn on the scraper and adjust the height of the scraper, so that the scraper is driven by the motor to scrape the chitosan solution into a thin layer and evenly distribute it on the surface of the flat microneedle mold.

[0086] iii. Turn on the power of the high-voltage electric field generator, adjust the output voltage to 40KV, establish a high-voltage e...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to a polymer microneedle preparation system and method. The system comprises a raw material solution storage tank, a metering and conveying pump, a flow-casting and film-scrapingdevice, a microneedle mold, an open metal box, a high-voltage electrostatic generator, a negative pressure regulating device and a hot air device; the raw material solution storage tank, the meteringand conveying pump and the microneedle mold are sequentially connected through pipelines; the flow-casting and film-scraping device comprises a scraper, a threaded push rod and a motor which are sequentially connected, and the scraper is located above the microneedle mold; the microneedle mold and the open metal box are connected through an insulating material and define a cavity; a positive electrode and a negative electrode of the high-voltage electrostatic generator are electrically connected with the microneedle mold and the open metal box respectively, the negative pressure regulating device is connected with the open metal box through a pipeline, and a hot air pipeline of the hot air device is located above the microneedle mold. The polymer microneedle preparation system is simplein equipment, convenient to operate, low in energy consumption and cost and capable of achieving large-scale production.

Description

technical field [0001] The invention belongs to the technical field of novel microfine precision molding and processing of polymer materials, relates to a technology for preparing polymer microneedles, and in particular relates to a system for preparing polymer microneedles and a method for preparing polymer microneedles. Background technique [0002] Microneedles refer to micro needles with a length of tens of microns to several millimeters and a tip diameter of less than tens of microns. It can effectively pierce the stratum corneum of the skin and form a drug delivery channel on the skin surface, so that the drug can reach the designated depth of the skin and enter the subcutaneous capillary network to be absorbed. Microneedle overcomes the shortcomings of low bioavailability of traditional transdermal patches and unsustainable administration of injections. It is painless, minimally invasive, maintains stable blood concentration, avoids liver first-pass effect, and improv...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61M37/00
CPCA61M37/0015A61M2037/0053
Inventor 谢德明
Owner 广州蔻原生物科技有限责任公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap