Polymer microneedle preparation system and method

Abstract

The invention relates to a polymer microneedle preparation system and method. The system comprises a raw material solution storage tank, a metering and conveying pump, a flow-casting and film-scrapingdevice, a microneedle mold, an open metal box, a high-voltage electrostatic generator, a negative pressure regulating device and a hot air device; the raw material solution storage tank, the meteringand conveying pump and the microneedle mold are sequentially connected through pipelines; the flow-casting and film-scraping device comprises a scraper, a threaded push rod and a motor which are sequentially connected, and the scraper is located above the microneedle mold; the microneedle mold and the open metal box are connected through an insulating material and define a cavity; a positive electrode and a negative electrode of the high-voltage electrostatic generator are electrically connected with the microneedle mold and the open metal box respectively, the negative pressure regulating device is connected with the open metal box through a pipeline, and a hot air pipeline of the hot air device is located above the microneedle mold. The polymer microneedle preparation system is simplein equipment, convenient to operate, low in energy consumption and cost and capable of achieving large-scale production.

Description

technical field [0001] The invention belongs to the technical field of novel microfine precision molding and processing of polymer materials, relates to a technology for preparing polymer microneedles, and in particular relates to a system for preparing polymer microneedles and a method for preparing polymer microneedles. Background technique [0002] Microneedles refer to micro needles with a length of tens of microns to several millimeters and a tip diameter of less than tens of microns. It can effectively pierce the stratum corneum of the skin and form a drug delivery channel on the skin surface, so that the drug can reach the designated depth of the skin and enter the subcutaneous capillary network to be absorbed. Microneedle overcomes the shortcomings of low bioavailability of traditional transdermal patches and unsustainable administration of injections. It is painless, minimally invasive, maintains stable blood concentration, avoids liver first-pass effect, and improv...

AI Technical Summary

Problems solved by technology

The existing preparation technology generally has low efficiency, complex manufacturing process, difficulty in batch preparation, and high manufacturing cost. The shape, structure, size uniformity and stability of the microneedles prepared at the same time are not ideal, and a single manufacturing method is not suitable for a variety of microneedle materials. and many more

[0009] (2) The drug-loading technology of microneedles is single and the application range is narrow

In the existing microneedle drug loading process, it is difficult to meet the loading requirements of water-soluble or fat-soluble drugs at the same time. The activity of the drug is significantly reduced, etc. Defects

[0010] (3) The adaptability of microneedles is poor

Existing metal and glass microneedle products have high physical and mechanical strength, large skin irritation, and damage to skin microvessels, resulting in redness or infection of the skin, and the remaining subcutaneous tissue of the broken tiny needle tip is difficult to remove and irritates the skin for a long time, causing a strong tingling sensation on the skin Make it difficult for consumers to accept, etc.

Microneedle products made of non-degradable polymer materials have good toughness but low mechanical strength. They are easy to bend during skin puncture and difficult to puncture the stratum corneum. The loading efficiency of water-soluble drugs is low, and often need to be used during processing. Organic solvents and organic solvents are difficult to remove, and the microneedles that enter the subcutaneous area are also difficult to remove and irritate tissues and other defects

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