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Preparation method for fibroin-based multifunctional nano drug and application thereof

A nano-drug and multi-functional technology, which is applied in the field of preparation of multi-functional nano-drugs, can solve the problems of intestinal microbial reconstitution that are rarely reported, and achieve the effects of improved pharmacokinetics, high yield, and easy release and accumulation

Inactive Publication Date: 2018-11-06
SOUTHWEST UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although nanomedicine has been widely used in the treatment of colitis, its remodeling of gut microbiota has rarely been reported

Method used

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  • Preparation method for fibroin-based multifunctional nano drug and application thereof
  • Preparation method for fibroin-based multifunctional nano drug and application thereof
  • Preparation method for fibroin-based multifunctional nano drug and application thereof

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Embodiment 1

[0036] Embodiment 1 is the preparation method of multifunctional nano-medicine based on silk fibroin, comprising the following steps:

[0037] (1) After silkworm cocoons are degummed with weak alkaline solution, they are completely dissolved with ternary solution, and regenerated silk fibroin is obtained after dialysis with deionized water;

[0038] (2) Dissolve regenerated silk fibroin in deionized water, hydrate overnight at room temperature to obtain hydrated regenerated silk fibroin;

[0039] (3) Weigh an appropriate amount of curcumin, and then completely dissolve it in acetone to obtain an acetone solution in which curcumin is dissolved;

[0040] (4) Add the hydrated regenerated silk fibroin obtained in step (2) dropwise into the curcumin-dissolved acetone solution obtained in step (3) while vortexing. At this time, the solution becomes cloudy and becomes an emulsion. Obtain the emulsion that contains CUR; The volume ratio of the regenerated silk fibroin after described...

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Abstract

The invention discloses a preparation method for a fibroin-based multifunctional nano drug and an application thereof. The preparation method includes first preparing regenerated fibroin fibers, thenpreparing curcumin (CUR)-loaded fibroin nanoparticles by desolvation, and then modifying the target molecule chondroitin sulfate (CS) on the surface. The nanoparticles have narrow particle size distribution (180.9 +- 2.8 nm), high drug loading capacity (3.3%) and good drug controlled release effect, and the nanoparticles have stimulates responsiveness of pH, GSH and ROS. According to the preparation method, the CUR with natural anti-inflammatory performance and the natural fibroin with good biocompatibility are assembled into the nanoparticles, and the surfaces of the nanoparticles are subjectto targeted modification, so that the enrichment in the lesion position is greatly improved, the release of the responsive drug is improved after the drug reaches the lesion position, the pharmacokinetic characteristic of the CUR is improved, and the therapeutic effect of the CUR on ulcerative colitis is enhanced.

Description

technical field [0001] The invention belongs to the technical field of nano-medicine carrier, and in particular relates to a preparation method, characterization and application of silk fibroin-based multifunctional nano-medicine. Background technique [0002] Ulcerative colitis (UC) is the most important type of inflammatory bowel disease, and its etiology may include environmental, infection, immune and genetic factors. People who carry certain genes may be more susceptible to UC. With the improvement of people's living standards, the number of cases of UC reported in China has also increased significantly in recent years. According to the statistics of cases in many hospitals, the prevalence of ulcerative colitis is 11.6 / 100,000, and the actual cases may be more. UC has become a common disease of the digestive system and the main cause of chronic diarrhea in China, and most of the patients are young and middle-aged, so it has been paid more and more attention. [0003] ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K47/42A61K47/36A61K31/12A61P1/04A61P1/00
CPCA61K9/146A61K31/12A61P1/00A61P1/04
Inventor 肖波苟双全汪敏
Owner SOUTHWEST UNIV
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