Tissue repair stent and preparation method and application thereof

Abstract

The invention provides a tissue repair stent and a preparation method and an application thereof. The tissue repair stent comprises: a fiber bundle comprising one or more filaments, the surface and / orinside of at least one filament is provided with functional powder; the filament material further comprises a biodegradable synthetic high molecular compound. The active ingredient in the functionalpowder of the tissue repair stent can be precipitated in the living body, which is targeted to stimulate the defect locally, and promote tissue regeneration; further, the tissue repair stent is provided with a suitable compressive modulus and the possibility of brittle fracture is small. The preparation method of the tissue repairing stent can adjust the average diameter of the single fiber filament and the pore diameter and porosity of the tissue repairing stent according to the needs of the defect site, thus, the mechanical properties of tissue repair stent at different defect sites can be satisfied, and the biological activities of the components in the stent can be retained in the printing process.

Description

technical field [0001] The invention relates to a tissue repair bracket and its preparation method and application, belonging to the field of medical implant materials. Background technique [0002] Bone defect is a common disease in orthopedic clinic. In clinical operations, bone repair materials are usually used to fill the defect to promote the regeneration of autologous bone tissue, thereby achieving the purpose of bone repair. However, the current bone repair materials have problems such as poor biocompatibility, insufficient bone cell induction performance, and inconsistent shape of actual bone defects in clinical practice, which cannot achieve good bone repair. [0003] In the prior art, the purpose of bone repair is also achieved through bone grafting. Although bone grafting can fill the bone cavity and accelerate the healing of bone defects, autologous bone grafting has been widely recognized by clinicians as the "gold standard" of bone filling technology. There a...

AI Technical Summary

Problems solved by technology

[0008] In view of the technical problems existing in the tissue repair process in the prior art, for hard tissue repair, for example: biocompatibility is not superior, bone cell induction performance is insufficient, the scaffold does not match the shape of the defect, etc.; for cartilage repair For example, the shape of the scaffold cannot meet the defect requirements, the mechanical properties of the scaffold do not match those of autologous cartilage, the ability to move cannot be restored as soon as possible, and tissues similar to hyaline cartilage cannot be formed after long-term use; technical problems of fibrosis are prone to occur; there is no long-term natural-like Biological properties of cartilage tissue, joint degeneration will occur within a period of time; donor shortage; poor interface bonding will cause rejection, etc.

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