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Method for Separating and Enriching Quercetin Using Metal-Organic Framework@Mesoporous Silicon Composite Material-Matrix Solid Phase Dispersion Technology

A metal-organic framework and composite material technology, applied in the field of separation and enrichment of quercetin, can solve the problems of low extraction rate, complicated operation process, and large consumption of organic solvents, and achieve simple separation process, increased adsorption capacity, and reduced experimental Effect of Time and Solvent Usage

Active Publication Date: 2019-12-31
NORTHEAST FORESTRY UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The present invention aims to solve the problems of complex operation process, low extraction rate and large consumption of organic solvent in the existing quercetin separation and extraction technology, and provides a method for separating quercetin by using metal organic framework @ mesoporous silicon composite material-matrix solid phase dispersion technology. Methods of Accumulating Quercetin

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  • Method for Separating and Enriching Quercetin Using Metal-Organic Framework@Mesoporous Silicon Composite Material-Matrix Solid Phase Dispersion Technology
  • Method for Separating and Enriching Quercetin Using Metal-Organic Framework@Mesoporous Silicon Composite Material-Matrix Solid Phase Dispersion Technology
  • Method for Separating and Enriching Quercetin Using Metal-Organic Framework@Mesoporous Silicon Composite Material-Matrix Solid Phase Dispersion Technology

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specific Embodiment approach 1

[0016] Specific embodiment 1: This embodiment is a method for separating and enriching quercetin by using a metal organic framework@ mesoporous silicon composite material-matrix solid phase dispersion technology, which is specifically completed according to the following steps:

[0017] 1. Preparation of metal organic framework@ mesoporous silicon composite material: ① Dissolve terephthalic acid in N,N dimethylformamide solution ultrasonically to obtain a solution containing terephthalic acid; The mass ratio of the N,N dimethylformamide solution to the volume ratio of 1g:(12~34)mL; ②, ultrasonically dissolve ferric chloride in the N,N dimethylformamide solution to obtain iron ion Solution; The mass ratio of the ferric chloride to the volume of the N,N dimethylformamide solution is 1g: (63~88) mL; ③, the solution containing terephthalic acid is added dropwise to the solution of iron ions , Then add MCM-41, ultrasonic treatment for 20min~35min, to obtain a yellow suspension; transf...

specific Embodiment approach 2

[0022] Specific embodiment two: the difference between this embodiment and the specific embodiment one is: the MCM-41 described in step one (3) is prepared according to the following steps:

[0023] Add CTAB and ammonia to deionized water, then stir at the oil bath temperature of 55~75℃ until CTAB is completely dissolved, then add TEOS dropwise, continue to stir and react for 5h~8h, then proceed to room temperature crystallization, filtration, washing and After drying, the solid product is obtained. The solid product is washed with hydrochloric acid ethanol solution until the washing liquid is neutral, and the washed product is vacuum dried to obtain white solid mesoporous silica, namely MCM-41; the quality of the CTAB is equal to The volume ratio of deionized water is (0.8~2.0)g:(90~120)mL; the volume ratio of the ammonia water and deionized water is (60~80):(90~120); the mass of the TEOS is The volume ratio of deionized water is (4.4-5.8) g: (90-120) mL; the mass fraction of hy...

specific Embodiment approach 3

[0025] Specific embodiment three: this embodiment is different from specific embodiment one or two in that the rotating speed of the centrifuge during centrifugal washing in step one (4) is 4000 r / min to 5500 r / min. Others are the same as the first or second embodiment.

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Abstract

The invention provides a method for separating and enriching quercetin by a metal organic framework@mesoporous silicon composite-matrix solid phase dispersion technology, relates to a method for separating and enriching quercetin and aims to solve the problems of complex operation process, low extraction rate and high organic solvent consumption in the existing quercetin separation and extractiontechnology. The method comprises the following steps: 1, preparation of the metal organic framework@mesoporous silicon composite; 2, solid-phase dispersion of a matrix: quercetin is separated by taking the metal organic framework@mesoporous silicon composite as a dispersant with the metal organic framework@mesoporous silicon composite-matrix solid phase dispersion technology as a separation method. The method has the advantage that total extraction rate of quercetin can reach 60-100 mg.g<-1>, and is used for separating and enriching quercetin.

Description

Technical field [0001] The invention relates to a method for separating and enriching quercetin. Background technique [0002] Quercetin, also known as Quercetin, is a flavonoid compound. It exists in the flowers, leaves and fruits of many plants, mostly in the form of glycosides. Quercetin can be used as a medicine, has good expectorant, antitussive effect, and has a certain anti-asthmatic effect. In addition, it has the effects of lowering blood pressure, enhancing capillary resistance, reducing capillary fragility, lowering blood lipids, dilating coronary arteries, and increasing coronary blood flow. Generally, the content of quercetin is extracted by supercritical extraction method, ultrasonic method, microwave method, etc. Liu Shan et al. (application number: 201410834869.6) In the method for extracting quercetin from water chestnut skin, acetone aqueous solution was used as the solvent to extract the quercetin from water chestnut skin. After the extract was extracted wit...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J20/22B01J20/30C07D311/30C07D311/40
CPCB01J20/226C07D311/30C07D311/40
Inventor 陈立钢王丹阳张頔娅赵晓虹
Owner NORTHEAST FORESTRY UNIVERSITY