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Eye drops as well as preparation method and application thereof

A technology of eye drops and water for injection, which is applied in the field of medicine, can solve the problems of low efficiency, achieve the effects of less toxic and side effects, inhibit platelet aggregation, and inhibit the formation of new blood vessels and thrombus

Active Publication Date: 2018-11-23
GUANGDONG LEWWIN PHARM RES INST CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Aiming at the problem that existing curcumin eye drops are not efficient in inhibiting new blood vessels, the purpose of the present invention is to provide a kind of eye drops that can well inhibit eye new blood vessels and have little toxic and side effects. The preparation method and application of the eye drops are provided

Method used

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  • Eye drops as well as preparation method and application thereof
  • Eye drops as well as preparation method and application thereof
  • Eye drops as well as preparation method and application thereof

Examples

Experimental program
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preparation example Construction

[0023] The present invention also provides a preparation method of the eye drops, which can adopt various existing preparation techniques for preparing eye drops; a preparation method is listed now, which includes the following steps: Bofei, then add curcumin to obtain liquid A; then mix uniformly with an appropriate amount of water for injection and pharmaceutically acceptable excipients, filter to obtain the filtrate, which is liquid B; then mix liquid A and liquid B, Add the rest of the water for injection, that is. The appropriate amount in this method means that the substance added to the water for injection can form a solution or suspension, and there is no specific limitation on the amount.

[0024] The eye drops of the present invention can be used for inhibiting ocular neovascularization and ocular thrombus formation, and can also be used for auxiliary treatment of cataract and other ocular diseases.

[0025] Below, in conjunction with specific embodiment, the presen...

Embodiment 1-3

[0027] Table 1: Formula table of embodiment 1-3 eye drops

[0028]

[0029] According to the technical scheme of the present invention, the optional adjuvant species for preparing curcumin eye drops is not limited to the species listed in the above table, and can also have the following multiple options:

[0030] As bacteriostatic agent, any bacteriostatic agent called in pharmacy can be used, and its consumption is according to the conventional dosage in pharmacy. For example, ① 0.002%-0.005% thimerosal; ② quaternary ammonium salts (including benzalkonium chloride, benzalkonium bromide), dumiphene, spirityl, etc., the effective concentration is 0.002%-0.01%; ③ alcohols, commonly used 0.3- 0.6% chlorobutanol; ④ Parabens, commonly used 0.03-0.06% ethylparaben; ⑤ Acids, such as 0.01-0.08% tricolic acid. The concentrations of the above substances are all volume-weight percentages, that is, every 100 milliliters contains grams.

[0031] Thickener: thickener commonly used in p...

experiment example 1

[0034] Stability test of experimental example 1 curcumin eye drops

[0035] Accelerated test: adopt the 0.005% curcumin eye drops prepared by the method of Example 2 of the present invention under commercially available packaging conditions, put into constant temperature and humidity box, at temperature 40 ℃ ± 2 ℃, relative humidity 25% ± 5% Placed under the same conditions, samples were taken on time at the first, second, third, and sixth months, and measured according to the quality standard draft. The results are shown in Table 2:

[0036] Table 2: Accelerated Test Data Sheet

[0037]

[0038]Long-term test: adopt the 0.005% curcumin eye drops prepared by the method of Example 2 of the present invention under commercially available packing conditions, put into constant temperature and humidity box, in the room of temperature 25 ℃ ± 2 ℃, relative humidity 40% ± 5%. Placed under the same conditions, samples were taken on time at the 3rd, 6th, 9th, 12th, and 18th months, ...

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Abstract

The invention discloses eye drops. The eye drops are prepared from the following preparation raw materials: curcumin, a mucosal adhesion polymer drug release system, water for injection and pharmaceutically acceptable accessories, wherein the mucosal adhesion polymer drug release system is prepared from radix notoginseng saponins and polycarbophil; the content of the curcumin in every 100mL of theeye drops is 0.001 to 0.01 g, and a proportion of the curcumin to the radix notoginseng saponins to the polycarbophil in parts by weight is 1:(0.3 to 3.0):(0.5 to 2). The eye drops disclosed by the invention have a good effect of inhibiting ocular neovascularization, and is non-irritant and safe. The invention also provides a preparation method and application of the eye drops.

Description

technical field [0001] The invention relates to the field of medicine, in particular to an eye drop and a preparation method thereof. Background technique [0002] Ocular neovascular lesions are one of the main causes of blindness. They can be seen in many fundus diseases. The exact pathogenesis is not yet fully understood. The prevention and treatment of neovascularization is the key to clinical treatment and the core issue of basic research. [0003] Curcumin, as one of the most important effective active ingredients of turmeric to exert pharmacological effects, has various pharmacological effects such as anti-oxidation, anti-tumor, anti-inflammation, anti-virus, inhibition of angiogenesis, protection of liver and kidney, etc., and has no obvious Toxic and side effects, has good clinical application prospects. For ocular disorders, topical medications offer many advantages over systemic medications. Subconjunctival and intravitreal injections can achieve effective drug c...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K36/258A61P7/02A61P27/02A61K31/12
CPCA61K9/0048A61K9/08A61K31/12A61K36/258A61P7/02A61P27/02A61K2300/00
Inventor 杨威郭健敏代彩玲
Owner GUANGDONG LEWWIN PHARM RES INST CO LTD
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