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Oral antimicrobial composition as well as preparation method and application thereof

A composition and oral technology, applied in the field of oral care, can solve the problems of ineffective adhesion, low drug utilization rate, inability to obtain ideal effects, etc., and achieve the effect of high utilization rate

Active Publication Date: 2018-11-23
GUANGZHOU LIBY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Some medical experts believe that even though toothpaste contains some active ingredients that can prevent and treat certain diseases, in the actual process, satisfactory ideal effects are often not obtained.
A very important reason for this result is: adding traditional medicines to toothpaste, after brushing teeth, most of the medicines are washed away and cannot be effectively attached to the oral cavity, resulting in low utilization of medicines

Method used

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  • Oral antimicrobial composition as well as preparation method and application thereof
  • Oral antimicrobial composition as well as preparation method and application thereof
  • Oral antimicrobial composition as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] A preparation method of an oral antibacterial composition, comprising the following processing steps:

[0040] Add 5 parts of cetylpyridinium chloride, 85 parts of ethyl cellulose, 5 parts of stearic acid, and 5 parts of polyvinyl alcohol (molecular weight is 75000) into the beaker, and add 75% ethanol solution, heat at 40 ° C and stir until mixed Evenly, the sample stock solution with a total mass fraction of each raw material of 10% was obtained, and passed through a spray dryer, and the parameters were set as follows: sample injection rate 10mL / min, air volume 60m 3 / h, atomization air pressure 0.1Mpa, air inlet temperature 140°C, needle pass frequency 60S, and powder particles with a particle size of 5 μm were prepared.

Embodiment 2

[0042] A preparation method of an oral antibacterial composition, comprising the following processing steps:

[0043] Add 5 parts of cetylpyridinium chloride, 70 parts of ethyl cellulose, 5 parts of stearic acid, 20 parts of polyvinyl alcohol (molecular weight is 75000) into the beaker, and add 75% ethanol solution, heat at 40 ° C and stir until mixed Evenly, the sample stock solution with a total mass fraction of each raw material of 10% was obtained, and passed through a spray dryer, and the parameters were set as follows: sample injection rate 10mL / min, air volume 60m 3 / h, atomization air pressure 0.1Mpa, air inlet temperature 140°C, needle pass frequency 60S, and powder particles with a particle size of 5 μm were prepared.

Embodiment 3

[0045] A preparation method of an oral antibacterial composition, comprising the following processing steps:

[0046] Add 10 parts of cetylpyridinium chloride, 70 parts of ethyl cellulose, 10 parts of stearic acid, 10 parts of chitosan (molecular weight is 300000) into the beaker, and add 75% ethanol solution, heat at 40 ℃ and stir until mixed Evenly, the sample stock solution with a total mass fraction of each raw material of 10% was obtained, and passed through a spray dryer, and the parameters were set as follows: sample injection rate 10mL / min, air volume 60m 3 / h, atomization air pressure 0.1Mpa, air inlet temperature 140°C, needle pass frequency 60S, and powder particles with a particle size of 5 μm were prepared.

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Abstract

The invention relates to an oral antimicrobial composition. The oral antimicrobial composition comprises the following components in parts by weight: 5 to 20 parts of cation bacteriocide, 5 to 20 parts of release-controlled agent, 40 to 85 parts of forming agent, and 5 to 20 parts of adhesive agent; the adhesive agent is selected from one or more of chitosan, polyethyleneimine, polyvinyl alcohol,hydroxy propyl cellulose and hydroxyethyl cellulose; the forming agent is selected from one or more of cyclodextrin and cellulose derivative; and the release-controlled agent is selected from one or more of fatty acid which is solid at the normal temperature and aliphatic ester. The oral antimicrobial composition adopts specific raw materials to be prepared into granular preparation to be added into toothpaste, so that the adhesion rate of the medicine in the oral cavity can be apparently improved, and the technical difficulty that the granular preparation medicine is difficult to adhere in the oral cavity after the tooth brushing can be solved.

Description

technical field [0001] The invention relates to the technical field of oral care, in particular to an oral antibacterial composition and its preparation method and application. Background technique [0002] Modern medical research believes that the existence of bacteria is a prerequisite for the occurrence of oral diseases. Oral bacteria and the plaque they form can easily cause oral problems, such as dental caries, periodontal disease, and bad breath. Drug prevention and treatment is currently the most effective way to treat and prevent oral diseases. In the traditional way of drug administration, most of the drugs are washed away by saliva or swallowed, resulting in a very short time for the drugs to reach the affected area, and the total amount of drugs is very low, resulting in low drug efficacy. [0003] In order to solve the above problems, most technologies improve the utilization rate of drugs by controlling the release rate of drugs, prolonging the action time of ...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K47/12A61K47/38A61K47/36A61K47/32A61K31/4425A61K31/155A61K31/14A61P1/02A61P31/02A61K8/02A61K8/49A61K8/43A61K8/41A61K8/36A61K8/73A61K8/81A61Q11/00
CPCA61K8/0216A61K8/361A61K8/416A61K8/43A61K8/4926A61K8/731A61K8/736A61K8/8105A61K9/0002A61K9/006A61K9/14A61K31/14A61K31/155A61K31/4425A61K47/12A61K47/32A61K47/36A61K47/38A61K2800/594A61Q11/00A61P1/02A61P31/02A61K2300/00
Inventor 陈伟才易丹郭建华罗勇张利萍
Owner GUANGZHOU LIBY
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