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A kind of medical suture with natural antibacterial drug slow-release function and preparation method thereof

An antibacterial, natural antibacterial technology, applied in the fields of medical science, surgery, coating, etc., can solve the problems of short sustained release time of antibacterial drugs, not easy to industrialize production, difficult to control drug loading efficiency, etc., to prolong hospitalization time and economical Burden, good biocompatibility and mechanical properties, effect of good biocompatibility

Active Publication Date: 2020-09-01
NANTONG TEXTILE & SILK IND TECH RES INST +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But, strict management has been arranged to the use of antibiotic class in the world, purpose is to avoid the abuse of antibiotics, to reduce the drug resistance of bacteria; ), due to the instability of the silver ion antibacterial agent in the preparation process, it is prone to oxidation and the antibacterial performance is reduced, and it is not conducive to the health of the human body; and Publication No. CN101584595A), using Andrographis paniculata, sodium houttuyniatin and silicone oil, methyl iodide-P-toluene sulfur dioxide and other Chinese and Western medicine mixture to soak sutures, but the antibacterial medical sutures prepared by this process have less drug loading , The sustained release time of antibacterial drugs is short, the drug loading efficiency is not easy to control, and it is not easy for industrial production. It is necessary to further improve the drug loading method and process route

Method used

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  • A kind of medical suture with natural antibacterial drug slow-release function and preparation method thereof
  • A kind of medical suture with natural antibacterial drug slow-release function and preparation method thereof
  • A kind of medical suture with natural antibacterial drug slow-release function and preparation method thereof

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Effect test

preparation example Construction

[0038] The preparation method of the above-mentioned medical suture with the slow-release function of natural antibacterial drugs comprises the following steps:

[0039] (1) Preparation of silk fibroin solution, weigh 30g silkworm raw silk in 12L boiling Na 2 CO 3 (0.02 M) degumming in aqueous solution for 30 minutes, stirring with a glass rod every 10 minutes to ensure the thoroughness of degumming, then rinse with deionized water several times, put the washed silk fibroin fiber in a fume hood overnight Air dry. Weighed 25 g of dried silkworm silk fiber and dissolved it in 100 mL of LiBr (9.3 M) solution, and dissolved it in an oven at 60 °C for 4 hours, during which time it was taken out and shaken slightly every hour to ensure complete dissolution. The solution was taken out and poured into a dialysis bag (MWCO 3500), dialyzed in deionized water for 36 hours, and the water was changed every 4 hours. The dialyzed solution was centrifuged twice at 9000 r / min in a high-spee...

Embodiment 1

[0053] This implementation case shows a preparation method of a medical suture with the slow-release function of natural antibacterial drugs, wherein the natural antibacterial drug is berberine, and the antibacterial coating formula for the inner (core thread) layer of the composite structure suture is: silk fibroin The mass ratio of berberine to berberine is 10:1, the concentration of berberine solution is 3-6 mg / mL, and the concentration of silk fibroin solution is 5-10% (w / v). There are two kinds of antibacterial coating formulations for the outer layer of composite sutures: (1) direct drug coating, the concentration of berberine solution is 3-6 mg / mL; (2) the mass ratio of silk fibroin to berberine is 10 :1, the concentration of berberine solution is 3-6 mg / mL, and the concentration of silk fibroin solution is 5-10% (w / v).

[0054] The inner (core thread) layer of the suture is prepared by the method of parallel arrangement of filaments. The inner layer of the suture adopt...

Embodiment 2

[0057] This implementation case shows a preparation method of a medical suture with the slow-release function of natural antibacterial drugs, wherein the natural antibacterial drug is chitin, and the inner core thread coating formula of the composite structure suture is silk fibroin and chitin The mass ratio is 100:2-10, the concentration of yellow chitin solution is 3-6 mg / mL, and the concentration of silk fibroin solution is 5-10% (w / v). There are two types of antibacterial coating formulations for the outer layer of the composite structure: one is direct coating of drugs, and the concentration of chitin solution is 3-6 mg / mL; the other is that the mass ratio of silk fibroin to chitin is 100:2-10. The concentration of the silk fibroin solution is 3-6 mg / mL, dilute the silk fibroin solution with deionized water to 5-10% (w / v), add glycerol to the silk fibroin solution, the ratio of glycerol to silk fibroin 30-50%, mix well.

[0058]The inner (core thread) layer of the suture...

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Abstract

The invention discloses a medical suture with the slow-release function of natural antibacterial drugs and a preparation method thereof. A composite structure weaving process is adopted, silk fibroin is used as a coating carrier, and natural antibacterial drugs are loaded to obtain an antibacterial medical suture with long-lasting antibacterial properties. Suture thread, the suture thread material has good mechanical properties, and at the same time has a long-acting slow-release drug effect, which can inhibit or kill bacteria and reduce surgical site infection.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a medical suture with a slow-release function of natural antibacterial drugs and a preparation method thereof. Background technique [0002] Medical sutures are the most common biomedical textiles for surgical implants. They are widely used in various surgical operations for suturing wounds, connecting tissues and ligating small blood vessels. The sutures with braided structure are easy to absorb and hide bacteria in the gaps and between single fibers, which increase the incidence of surgical site infection. Surgical site infection not only affects wound healing, brings pain to patients, prolongs hospital stay, but also increases the economic burden on patients and society, and is even an important cause of postoperative death. Sutures are the channel for bacteria to enter the surgical incision. If the sutures have antibacterial properties, they can prev...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L17/12A61L17/10A61L17/14A61L17/00D06M15/15D06M15/03
CPCA61L17/005A61L17/10A61L17/105A61L17/12A61L17/14A61L2300/404A61L2300/606D06M15/03D06M15/15D06M16/00C08L67/04C08L89/00
Inventor 李刚贺超恒王晓沁
Owner NANTONG TEXTILE & SILK IND TECH RES INST
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