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Modified kgm lecithin-loaded nmn transdermal protosomes, preparations, preparation process and application

A technology of transdermosome and ethosome, which is applied in the field of preparations and biopolymer material modified KGM lecithin loaded with NMN transdermal ethosome, which can solve the problems of short biological half-life, limited potential application, frequent administration, etc. Achieve the effects of high encapsulation rate, stable thermodynamic properties, and fast transdermal performance

Active Publication Date: 2020-12-01
HOBOOMLIFE BIO TECH SHENZHEN CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, its potential application is limited due to its poor stability at room temperature, short biological half-life, easy enzymatic degradation, and immunogenicity.
At present, NMN has a variety of administration methods, such as oral, injection, etc., but due to the nature of the drug itself, it inevitably leads to the disadvantage of frequent administration

Method used

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  • Modified kgm lecithin-loaded nmn transdermal protosomes, preparations, preparation process and application
  • Modified kgm lecithin-loaded nmn transdermal protosomes, preparations, preparation process and application
  • Modified kgm lecithin-loaded nmn transdermal protosomes, preparations, preparation process and application

Examples

Experimental program
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Embodiment 1

[0043] This embodiment provides a modified KGM lecithin-loaded NMN transdermal ethosome, which consists of the following components in terms of mass percentage: 0.03% of NMN, 0.1% of konjac glucomannan, and 1% of phospholipid , cholesterol 0.05%, stabilizer 0.1%, antioxidant 0.15%, low molecular weight alcohol 5%, and the balance is water. Wherein, the konjac glucomannan (KGM) includes an equal amount of quaternized konjac glucomannan (QKGM) and carboxymethyl konjac glucomannan (CKGM), the phospholipid is soybean lecithin, and the The stabilizer is dicetyl phosphate, the antioxidant is vitamin C, and the low molecular weight alcohol is glycerol.

[0044] The modified KGM lecithin-loaded NMN transdermal protosome gel can be used in medicines for treating Alzheimer's disease, Parkinson's disease and muscular dystrophy, as well as in anti-oxidation and anti-aging preparations.

[0045] This embodiment also provides a modified KGM lecithin-loaded NMN transdermal etosome gel, whic...

Embodiment 2

[0058] This embodiment provides a modified KGM lecithin-loaded NMN transdermal ethosome, which consists of the following components in terms of mass percentage: 1% NMN, 10% konjac glucomannan, 10% phospholipid, Cholesterol 1%, stabilizer 0.5%, antioxidant 1%, low molecular weight alcohol 50%, and the balance is water. Wherein, the konjac glucomannan (KGM) includes quaternized konjac glucomannan (QKGM) and chitosan (CS), the mass ratio of the two is 1:2, and the phospholipid is egg yolk lecithin, Described stabilizer is the mixture of phospholipid phthaloglycerol and phosphoric acid ester, and the mass ratio of the two is 1:1, and described antioxidant is the mixture of vitamin E, di-tert-butyl-p-cresol, and the mass ratio of the two is 1:1: 2. The low molecular weight alcohol is ethanol.

[0059] The modified KGM lecithin-loaded NMN transdermal protosome gel can be used in medicines for treating Alzheimer's disease, Parkinson's disease and muscular dystrophy, as well as in an...

Embodiment 3

[0069] This embodiment provides a modified KGM lecithin-loaded NMN transdermal ethosome, which consists of the following components in terms of mass percentage: NMN 5%, konjac glucomannan 5.5%, phospholipid 6% , cholesterol 0.5%, stabilizer 0.3%, antioxidant 0.45%, low molecular weight alcohol 30%, and the balance is water. Wherein, the konjac glucomannan (KGM) comprises a mixture of oxidized konjac glucomannan (OKGM) and quaternized konjac glucomannan (QKGM), the mass ratio of the two is 1:2, and the phospholipid It is hydrogenated soybean lecithin, the stabilizer is phosphatidyl phthaloserine, the antioxidant is a mixture of malic acid and β-carotene, the mass ratio of the two is 1:1, and the low molecular weight alcohol is n-butanol and A mixture of ethanol, the volume ratio of the two is 1:2.

[0070] The modified KGM lecithin-loaded NMN transdermal protosome gel can be used in medicines for treating Alzheimer's disease, Parkinson's disease and muscular dystrophy, as well...

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Abstract

The invention discloses a KGM (konjac glucomannan) modified lecithin-loaded NMN transdermal ethosome, and belongs to the technical field of production of medicinal preparations. The ethosome comprises, by mass, 0.03-1% of NMN, 0.1-10% of konjac glucomannan, 1-10% of phospholipid, 0.05-1% of cholesterols, 0.1-0.5% of a stabilizer, 0-1% of an antioxidant, 5-50% of a low molecular weight alcohol, andthe balance of water. The KGM modified lecithin-loaded NMN transdermal ethosome is a novel multi-chamber vesicle structure with a spherical or nearly-spherical shape, and has the advantages of stablethermodynamic characteristics, smaller particle size, high encapsulation efficiency, fast and strong transdermal performance, good tolerance of skins, reduction of the dosage, reduction of the incidence of adverse reactions, and improvement of the safety. The invention also discloses a gel containing the ethosome, and preparation technologies of the ethosome and the gel. The gel has the advantages of fine texture, good absorption property in human bodies, simple preparation process, mild conditions, and suitableness for industrial batch production.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparation production, and in particular relates to a biopolymer material-modified KGM lecithin-loaded NMN transdermal ethosome, a preparation, a preparation process and application thereof. Background technique [0002] Transdermal drug delivery system is a new type of drug delivery system, which has become one of the fastest growing fields in the pharmaceutical industry due to its more humanized drug delivery treatment characteristics and continuous development of transdermal technology. It refers to a new dosage form that is administered on the surface of the skin, and the drug penetrates through each layer of the skin at a certain rate, enters the blood circulation of the human body from the capillary to achieve effective blood drug concentration, and realizes systemic or local therapeutic effects. Compared with oral and intravenous injection, transdermal drug absorption is not affecte...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/127A61K47/36A61K31/706A61P25/28A61P25/16A61P21/00A61P39/06A61P17/00
CPCA61K9/1271A61K31/706A61K47/36A61P17/00A61P21/00A61P25/16A61P25/28A61P39/06
Inventor 王运刘喜元方秋杰陈娜叶小舟
Owner HOBOOMLIFE BIO TECH SHENZHEN CO LTD
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