Paeoniflorin composition for treating gastrointestinal dysfunction or irritable bowel syndrome and application thereof

A technology for irritable bowel syndrome and gastrointestinal dysfunction, which is applied in the field of natural pharmaceutical compositions to achieve the effects of clear chemical composition, reduced clinical dosage, and improved preparation level

Inactive Publication Date: 2018-12-07
NANJING XINTONG RUIYI MEDICINE SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] At present, there is a lack of a traditional Chinese medicine extract composition and its application for the ...

Method used

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  • Paeoniflorin composition for treating gastrointestinal dysfunction or irritable bowel syndrome and application thereof
  • Paeoniflorin composition for treating gastrointestinal dysfunction or irritable bowel syndrome and application thereof
  • Paeoniflorin composition for treating gastrointestinal dysfunction or irritable bowel syndrome and application thereof

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0075] Effect of Composition on Visceral Hypersensitivity in Irritable Bowel Syndrome Model Rats

[0076] 1. Experimental animals and medicines are provided through legal channels. Pinaverium Bromide Tablets 50mg / tablet (Abbott Products SAS) for experiments; paeoniflorin (98%), glycyrrhizic acid (95%), naringin (98%), hesperidin (98%), isoliquiritin for experiments (98%), Liquiritin (98%) and Neohesperidin (98%) were provided by Nantong Feiyu Biotechnology Company. The relevant extracts used in the experiment were prepared by ourselves, paeoniflorin extract (content greater than or equal to 20%), glycyrrhizic acid (content greater than or equal to 20%), naringin (content greater than or equal to 20%), hesperidin (content greater than or equal to 20%), neohesperidin extract (content greater than or equal to 20%), liquiritin (content greater than or equal to 10%), isoliquiritin (content greater than or equal to 5%). The decoction pieces of traditional Chinese medicine used in ...

experiment example 2

[0127] Effects of the composition on 5-HT signaling pathway and TRPV1 in visceral hypersensitive rats.

[0128] 1. Experimental animals, medicines, modeling, and test product preparation: the same as in Experimental Example 1.

[0129] 2. Experimental method

[0130] Rat colon tissue sample collection: 2 hours after the last gavage, the rats were executed by decapitation, and 3 segments of the colon 3 cm above the anus were taken, each segment 1-2 cm, washed with normal saline and PBS buffer solution (pH 7.4) respectively , blotted dry with filter paper, accurately weighed, quickly frozen with liquid nitrogen, and stored at -80°C for later use.

[0131]5-HT, 5-HT3R, 5-HT4R, TPH1, and SERT protein expression levels in rat colon were measured by enzyme-linked immunosorbent assay (ELISA). The rat colon tissue pieces were washed with PBS buffer, and the tissue was homogenized by adding appropriate saline. slurry, and centrifuged to obtain the supernatant. According to the instr...

experiment example 3

[0155] The adjustment of experimental example 3 to the gastrointestinal dysfunction rat caused by reserpine

[0156] 1. Animals and reagents are the same as in Experimental Example 1.

[0157] 2. Animal grouping and dosage: (1) Normal group was injected intraperitoneally with equal volume of normal saline, and at the same time fed with equal volume of distilled water; (2) Model group: intraperitoneally injected with reserpine 0.5 mg / kg, and simultaneously fed with equal volume of distilled water (3) Positive group: intraperitoneal injection of reserpine 0.5mg / kg, and at the same time, 50 mg / kg of Suliqenone was administered; (4) sample group: intraperitoneal injection of reserpine 0.5mg / kg, and simultaneously, the test samples were administered (with experimental example one). Each group was administered continuously for two weeks. The feces and signs of the rats were observed at any time, and the body weight and food intake of the rats were weighed every day. The following...

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Abstract

The invention discloses a paeoniflorin composition for treating gastrointestinal dysfunction or irritable bowel syndrome and application thereof. The paeoniflorin composition for treating gastrointestinal dysfunction or irritable bowel syndrome is composed of paeoniflorin and a component A. The component A comprises one or a combination of more than one of naringin, hesperidin, neohesperidin, isoliquiritin, liquiritin and glycyrrhizic acid. By selectively using the natural composition, the paeoniflorin composition has synergistic regulation and multi-target correction effects on a 5-HT signalchannel. The fact that the optimized combination of natural components has more excellent effect than original single component or a Chinese herbal compound extract is put forward in the invention. Onthis basis, ratio of the composition is further optimized, and the best effect is achieved.

Description

technical field [0001] The invention relates to a natural medicine composition, in particular to a traditional Chinese medicine extract composition for treating gastrointestinal dysfunction or irritable bowel syndrome and its application. Background technique [0002] Gastrointestinal dysfunction is a common clinical functional intestinal disease, accounting for about 40-60% of gastrointestinal diseases. Among them, irritable bowel syndrome (irritable bowel syndrome, IBS) is a common non-organic intestinal dysfunction disease of the digestive tract, which has the clinical characteristics of chronic recurrent attacks. The prevalence in adults ranges from 10% to 22%. Its main clinical manifestations are abdominal pain, diarrhea, constipation and other digestive system symptoms without organic lesions, and its etiology is gastrointestinal dysfunction. There is currently no effective treatment for this disease. [0003] Since modern medicine has not yet clarified its patholog...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K31/704A61K31/7034A61P1/00
CPCA61K31/7034A61K31/704A61K31/7048A61P1/00A61K2300/00
Inventor 杨星昊杨天倚
Owner NANJING XINTONG RUIYI MEDICINE SCI & TECH
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